Epigenetics and human disease research lab at Case Western Reserve University School of Medicine -- Department of Genetics & Genome Sciences
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- Following 577
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Scacheri Lab retweeted
Genome wide association studies have been used to identify genes that may be linked to opioid use disorder, but need hundreds of thousands of samples.
@MeWantData & collaborators have developed a way to identify these genes, using a small # of samples: wi.mit.edu/news/opioids-and-…
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Scacheri Lab retweeted
Epigenetic convergence in opioid overdose. Great to see this multi-team collaboration in print! Such a great group of people on this project. S. Akbarian, D. Mash, E. Johnson, D. Hancock, @ScacheriLab @Bun_Without_B
nature.com/articles/s41380-0…
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Scacheri Lab retweeted
TWEETORIAL on our new #radonc paper in @TheLancetOncol -- joint work from @CCLRI @MoffittNews @CWRUSOM 1/n
Pan-cancer prediction of radiotherapy benefit using genomic-adjusted radiation dose (GARD): a cohort-based pooled analysis
thelancet.com/journals/lanon…
@OncoAlert
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Our studies are expanding from cancer into other major public health crises. Check out our latest on opioid use disorder. Team effort with Akbarian, Johnson, Mash, and @CorradinLab. biorxiv.org/content/10.1101/…
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Scacheri Lab retweeted
Recruiting talented data scientists and molecular biologists to work on our newly funded project 👇🏼! This is our collective brainchild with @BullmanLab & @CJohnstonLab1.
Please retweet! Interested applicant please email tinga@ccf.org wmkeck.org/grant-programs/re…
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Fabulous ecDNA study by Henssen and Koche! Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma | Nature Communications nature.com/articles/s41467-0…
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This article is great! cen.acs.org/pharmaceuticals/…
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Scacheri Lab retweeted
Evolutionary therapy is a new subfield in medicine (distinct from #evomed) that seeks to use our understanding of evolution to enable novel #cancer (& pathogen) therapy. Here we present the first link between #evotherapy and quantum physics. A #thread
nature.com/articles/s41567-0…
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Scacheri Lab retweeted
How does resistance to targeted therapy develop in #lungcancer? Is it pre-existence or a de novo mechanism? @AndriyMarusyk lab @MoffittResearch adds evidence for a truly Darwinian, gradual development from tolerant persisters to full resistance. A THREAD nature.com/articles/s41467-0…
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Congrats to @CorradinLab!
Multiple sclerosis (MS) is considered an autoimmune disease. Researchers in the @CorradinLab led by @annAmbarbeau & the @TesarLab led by Daniel Factor found a role in MS for cells in the central nervous system—a potential new avenue for MS therapies: ow.ly/xUDc50z4sVb
ALT Microscopy image of nerve fibers in red with oligodendrocyte cells in green
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Big congrats to freshly minted PhD, Andrew Morton. He just successfully defended his thesis online! @morton_andrew #DamnProud
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To stop COVID-19, test everyone, repeatedly - Sten Linnarsson - Medium medium.com/@sten.linnarsson/…
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Scacheri Lab retweeted
Finished off with some historical sites in Jerusalem, including the western wall. Great tour with @caseccc colleagues including @ScacheriLab
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Scacheri Lab retweeted
Excellent preview in @Cancer_Cell covering recent work on the role of extrachromosomal circular DNA in cancer, including our study in @NatureGenet with @anton_gh et al. Thank you for the highlight, Chris Ott. cell.com/cancer-cell/pdf/S15…
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A must read. Great work from Lupien Lab.
My team's latest publication deepening our understanding of the noncoding cancer genome: Noncoding mutations target cis -regulatory elements of the FOXA1 plexus in prostate cancer disq.us/t/3lj6ta2
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Scacheri Lab retweeted
Check out our first preprint! Together with @RichardKoche @CMskcc we show that MYCN amplicon structure is not only determined by local enhancers , as shown by @ScacheriLab @CellCellPress but that chimeric amplicons can recruit distal enhancers leading to enhancer hijacking.
Enhancer hijacking determines intra- and extrachromosomal circular MYCN amplicon architecture in neuroblastoma biorxiv.org/cgi/content/shor… #biorxiv_cancer
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Scacheri Lab retweeted
Here’s a link to read and download for those without a subscription. Check it out! authors.elsevier.com/c/1a8FU…
1/ So excited to have our work joint with the Rich lab lead by @morton_andrew published in Cell @CellCellPress today: “Functional enhancers shape extrachromosomal oncogene amplifications”. cell.com/cell/fulltext/S0092…
#tweetorial below
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ecDNA is hot! We encourage you to also read yesterday’s @nature paper lead by @mischellab @HowardYChang Bing Ren and Vineet Bafna.
nature.com/articles/s41586-0…
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