PI: Kristina Simonyan | Dystonia | Laryngeal Dystonia | Speech Production | Central Motor Control | Neuroimaging | Genetics | DystoniaNet AI
MEE/MGH/MGB/Harvard Med School
Based in United States
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- Followers 565
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I am pleased to announce our first P50 Center hybrid seminar by Dr. Shiro Horisawa from @TWMU_function on “Surgery at Forel’s Field for #MovementDisorders and Beyond”.
Join us on May 8th, 4-5 pm EDT, virtually or in person, if you are in Boston area.
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Very exciting presentation by @Maitreyee_W with an amazing advance toward real-time synthesis of continuous speech from neural signal in premotor 6v cortex 👏👏👏 The door to endless possibilities in speech rehabilitation & treatment! @sergeydoestweet @DrDavidBrandman #BCImeeting
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Very engaging poster session and presentation by @ehrlich_sk on #BCI for treatment of focal #dystonia at #BCImeeting @BciSociety @dmrf
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we developed & tested a deep-learning platform #DystoniaBoTXNet to automatically determine the #BotulinumToxin treatment efficacy. Based on structural brain MRI, DystoniaBoTXNet discovered treatment #marker & achieves 96.3% accuracy in 19.2 sec in predicting injection efficacy.
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Very excited & proud of the @SimonyanLab team for developing the first #BCI (brain-computer interface) for patients w laryngeal #dystonia and starting this one-of-a-kind clinical trial bit.ly/3N7RYBk! Grateful to @NIDCD for funding. Follow us for updates & participation!
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Pathophysiology involves widespread alterations of neural network function and structure, abnormal dopaminergic and GABAergic function, & maladaptive plasticity. Alterations of premotor-parietal regions are of critical importance being influenced by external and polygenic risks.
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Genetic & extrinsic risk factors may trigger symptoms of laryngeal #dystonia in susceptible individuals. Understanding genetic/extrinsic risk interplay with neural changes may lead to novel preventive approaches.
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Laryngeal #dystonia diagnosis is challenging & may extend over 5 years. Clinical assessment should include a detailed case history, auditory-perceptual testing, nasoendoscopy & neuro exam. The highest priority is the development & implementation of accurate diagnostic biomarkers.
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Based on objective microstructural biomarker and using raw structural MRI, DystoniaNet achives 98.8% accuracy in diagnosing laryngeal dystonia, cervical dystonia and blepharospasm, while referring 3.5% of cases for further examination. The speed of diagnosis is 0.36 sec!
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The biomarker components include alterations in corpus callosum, thalamic radiation, inferior fronto-occipital fasciculus, inferior temporal and superior orbital gyri, all of which are known to contribute to various aspects of #dystonia pathophysiology.
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It’s a poster award season for the lab! Congratulations to Laura de Lima Xavier @XavierLL1 & Sandra Hanekamp @sandrahanekamp for winning the Best Poster Design Award at Boston Speech Motor Control Symposium #2019BSMCS
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Job posting from our collaborators @SichaniL @UMassMedical #OHBM2019 More info neurojobs.sfn.org/jobs/12349…
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A wonderful Keynote address at #NetSci2019 by amazing @tinaeliassi on machine learning, ethics and ways to achieve fairness
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Very proud of Alexis Worthley who presented the first talk of the scientific session at American Laryngological Association #ALA #2019COSM bit.ly/2RdIQTe
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Our newest paper on Top-down alterations of functional connectivity within the sensorimotor network in focal #dystonia is out & on the cover of @GreenJournal Details here bit.ly/2W3BNup CC: @GvnBattistella
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Our collaborator Dr. Farid Hamzei-Sichani from @UMassMedical just wrapped up his interview @AWSreInvent. Next is @DavideValeriani at 5:25pm EST. Watch twitch.tv/AWS
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Our latest study @SciReports supported by @NIDCD details the mechanisms of a new oral drug for patients with alcohol-responsive #dystonia.
"A novel therapeutic agent, sodium oxybate, improves dystonic symptoms via reduced network-wide activity"
rdcu.be/barCw
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Defining Emergent Opportunities in #Dystonia Research is happening now at NIH! Listen to the talks and discussions via WebEx
Day 1 registration bit.ly/2JltO6t
Day 2 registration bit.ly/2Pwec5C
CC: @NINDSnews @NIDCD
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Our new paper on brain networks in #dystonia is out in Movement Disorders @movedisorder. Disorganized network kernel specific for each type of dystonia drives disorganization of a larger scale functional connectome bit.ly/2zJ2LPx
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If you are in Boston area, we are returning to the Voice & Speech Lecture Series @MassEyeAndEar after the summer break with a talk by Glenn Bunting, MS, CCC-SLP, on the treatment of functional voice and speech disorders. Join us on Sept 17, 12-1pm.
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2- It is a time to turn to objective measures that are based not solely on experience of a physician/SLP with #SpasmodicDysphonia but are rooted in disease pathophysiology. Using brain imaging & machine learning, the accuracy of diagnosis is up to 81%. bit.ly/2tJKkWK
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Laura de Lima Xavier is presenting our latest study on the role of environmental risk factors in developing laryngeal dystonia. Poster #2120 @OHBM
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Daniel Moyer is presenting our collaborative study with @aram_galstyan on the power of a new CorEx method (based on multivariate mutual information maximization) to increase replicable effect sizes. Poster #1781 @OHBM
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Today, Laura De Lima Xavier from @SimonyanLab presented her data on functional brain differences between distinct voice tremor phenotypes at the 1st International Tremor Congress at Columbia University
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This paper is a product of 30 years of work and wonderful collaborations with Andy Blitzer, Mitchell Brin, Steve Frucht and Laurie Ozelius - Phenomenology, Genetics, and CNS Network Abnormalities in Laryngeal #Dystonia in The Laryngoscope @Triological cc @NSDA_SD
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New paper from our lab at J Comp Neurol @neuroscience: Dopamine drives left-hemispheric lateralization of neural networks during human speech. Read more here goo.gl/YdQ8DJ
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Judge for yourself! This is how whole brain funx connectivity looks like in diff forms of laryngeal #dystonia (or #spasmodicdysphonia).
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Our farewell lunch with Giovanni Battistella, a great postdoc fellow @SimonyanLab. Best of luck at UCSF!
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30 years and counting in defining symptoms, treatment & causes of #SpasmodicDysphonia - Dr. Blitzer's talk at ALA17
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Very proud to be nominated by Dr Andrew Blitzer and indicted today as an Associate Felow of American Laryngological Association!
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We are grateful to @NIDCD for continuously funding our study on Imaging Genetics of #SpasmodicDysphonia! Read more goo.gl/DNrrEo
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Our 1st paper of 2017 is out in @movedisorder: #Dystonia phenotype & genotype have very distinct impact on pathophys of spasmodic dysphonia
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Our lab's high-schl student Jacob Yatvitskiy is named #RegeneronSTS Scholar, the nation's most prestigious pre-college #Science competition!
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@SimonyanLab is looking for a research assistant to start immediately. Please RT! More info here goo.gl/mgvBvd
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@pantaray0815 is presenting On the Feasibility of Epileptic Seizure Forecasting using Intracranial High Frequency Connectomics #BrainModes
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Join us #sfn16 Sunday morning to learn complexities of speech motor control w @Simonyanlab, Eddie Chang, Jeremy Greenlee, Hermann Ackermann
Hot off the @WSJscience press by @danielas_bot - Our research on speech production and spasmodic dysphonia @NSDA_SD @dmrf @NIDCD
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Our JoCN paper on Stability of #network communities as a function of task complexity is out! tinyurl.com/z5pddkd
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Our new study shows modular #HFO #network breakdown in #epilepsy 225s before seizure starts tinyurl.com/jcr68rx
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Read our new imaging study on neural correlates of #dystonia #tremor in Brain Imaging Behav tinyurl.com/zvrx6x3
Stefan Fuertinger and the stability of network communities at @Neurosci2015 abstractsonline.com/Plan/Vie…
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