Associate Professor; Translational science laboratory at OSU-James CCC focused on researching immunotherapy in pancreatic and lung cancer

Columbus, OH
Congrats to MCDB graduate student Jess Wedig in the lab for defending her PhD yesterday. Very proud and excited for her next steps! @OSUCCC_James
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11th year riding! Another great Pelotonia ride! Thanks to all who donated!!! @OSUCCC_James @OhioStatePIIO @Pelotonia
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Great time last night for our laboratory holiday dinner. Lots to celebrate this year with more to come!
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Great time at the 2025 @sitcancer annual meeting. Learned a lot this week and got to catch up with colleagues! @Pelotonia scholar Jess Wedig presented her work at the meeting @OhioStatePIIO @OSUCCC_James
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Another ride in the books. Thanks for everyone who has supported my @Pelotonia ride. Still time if you want to donate: pelotonia.org/profile/TM0139 @OSUCCC_James @OhioStatePIIO
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Fun opening ceremony. Mace lab is ready for the ride tomorrow! This will be my 10th @Pelotonia ride!!! @OhioStatePIIO @OSUCCC_James
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Mace lab had a great time this afternoon checking out a Columbus Clippers game!
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Replying to @PitarresiLab

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Happy national dog day! Owen, Higgs, and Maple are all tired after a very hard day of sleeping.
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Great time catching up at the 2024 @Pelotonia opening ceremony! @ZCMlab @dwightowenmd
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Grants are not the only rejection I have received lately. Will try again next year.
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Thank you Hannah for being an awesome lab manager these past two years. Proud of your hard work and excited you are continuing your education here at OSU to get your PhD!!
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Huge news today…finally! Great score on our sR01!!!
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Congrats to Dr. @Debi_Mukh for defending her PhD thesis! First grad student to graduate out of the Mace lab. Proud of all you accomplished and excited for your future! @OSUCCC_James @OhioStatePIIO
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I have the best crew! My lab surprised me with cake at lab meeting to celebrate my birthday and promotion. 🙏🙏
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It’s official…I have been promoted to associate professor with tenure! Thank you to all my family, friends, lab members, and colleagues for supporting me! Lots more research, grants, papers, and work to be done…Onwards!
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Very cool to be able to see northern lights from my backyard here in Ohio!
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Thank you @GIPapachristou for nominating me for the Rising Star lecture at the department of internal medicine scientific symposium.
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Great time this afternoon enjoying all the successes in the lab during our happy hour. Proud of all their work!
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Congrats to @Debi_Mukh for winning 2nd place in the student poster at the @OSUCCC_James Center for Cancer Metabolism meeting today! #proudPI
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Also, MMP3 and MMP11 correlate with soluble CD200.
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We also discovered that PDAC patients with high soluble CD200 have worse survival.
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We report using multiplex IF that CD200 is upregulated in the pancreatic TME.
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A couple more great photos
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My brother in law had all of his expensive telescopes. Got a great shot of totality
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Fun time enjoying the eclipse. Wow what an experience! We had 3 minutes of totality!
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Paper accepted!!! Great news to receive on a Friday!

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Mace lab celebrating Pi day!
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Great job by Liliana, a senior undergrad in the lab, presenting her research in the Denman Research Forum. Mentored by grad student @Debi_Mukh
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The lab received not so great grant news yesterday, but this morning received great news on a paper (minor revisions).

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Very proud of both MCDB grad students Jess Wedig and @Debi_Mukh for winning best oral talks at the @TRCCC1998 breakout trainee sessions. A great showing by @OSUCCC_James and @OhioStatePIIO #trccc2024
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Replying to @LesinskiLab

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Great job by grad students @Debi_Mukh and Jess Wedig in the lab, both giving oral breakout session talks @TRCCC1998 #trccc2024
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R01 submitted today! 🤩 Also received email that another grant was rejected. 🤦‍♂️

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Ready for the stress, let’s beat the Chiefs! #GoBills
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Spending the weekend curling in the Detroit Men’s International Bonspiel…good times. 🥌🥌
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Had a fun time last night for Columbus Zoo lights. Definitely gets one into the holiday spirit 🎄
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Spent the weekend curling at the Fort Wayne bonspiel. Our team didn’t do well, but still lots of fun. 🥌
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In the year of our lord 2023, why are people still using Panc02 cells in their pancreatic cancer research!!! 🤦‍♂️🤦‍♂️

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One word that I need to keep in my thoughts…PERSEVERANCE. Received a close but not fundable R01 score today, a large pile of grants to still review, and a Nov R01 resubmission to finish.

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Great presentation from @ZCMlab at the #AACRPan23 meeting! Great job representing the strong pancreatic cancer research at @OSUWexMed
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Check out senior grad student @Debi_Mukh poster (B097) during the Thursday afternoon session at #AACRpan23
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It was nice getting the lab together for a happy hour to start off the fall semester!
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Further, we found tomatidine induces ferroptosis-mediated cell death in pancreatic cancer cells
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We found that Tomatidine inhibits pancreatic tumor growth and enhances gemcitabine chemosensitivity. Also, tomatidine reduces binding of ATF4 with downstream promoter elements
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Very excited to announce publication of a new research article in iScience from the lab and @Pelotonia funded MCDB grad student @Debi_Mukh titled, “Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression” cell.com/iscience/pdf/S2589-…
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Replying to @LesinskiLab

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Another great opening ceremony with my @Pelotonia graduate fellow @Debi_Mukh. My son was old enough this year to enjoy in the festivities. Excited for tomorrow’s ride! @OSUCCC_James @OhioStatePIIO
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Enjoying a final night of our beach vacation! It was nice to recharge! Ready for @Pelotonia next weekend!
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Definitely ready for a vacation. Just submitted my 3rd NIH R01 as PD/PI this cycle. Thankful for all the help from my lab and collaborators. Never submitting that many again in one cycle!

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Sat on my first NIH study section. Exhausted, but a very rewarding experience. Cherry Blossoms in full bloom and made a pit stop before heading to the airport.
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Another fantastic @TRCCC1998 meeting. Great seeing everyone and hearing about all the great work. Congrats to grad students in the lab @Debi_Mukh and Jess for winning awards at the meeting! #proudPI #TRCCC2023
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Merry Christmas from the Mace Family. Stay safe and warm this holiday season!
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Great job to the entire lab at the @OhioStatePIIO scientific annual meeting. Flash talk by @Debi_Mukh and a 3rd place poster award to 2nd year grad student Jess Wedig! #proudPI
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Sorry to miss out and catch up with everyone at SITC, but I was partaking in another one of my passions. Had a lot of fun at a curling tournament up in Fort Wayne this weekend. Team I skip went 2-2 and we had a blast.
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Due to everyone traveling and going home for the semester, we had to have an early lab holiday dinner. Crazy how much the lab has grown. Proud of all the work they are doing!
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Huge congratulations to @Debi_Mukh in the laboratory who was recently awarded a highly competitive @Pelotonia graduate student fellowship for her research on pancreatic cancer. Well-earned and deserved!! @OSUCCC_James @OSUWexMed @OhioStatePIIO
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Go Bills! Enjoying a nice night of football
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Nice to be back in person and catch up with everyone at the @OSUCCC_James annual scientific meeting. @OhioStatePIIO
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One R01 submitted successfully to NIH! One more to go!

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Academic life: This Saturday morning I am reviewing my final R01 pdf while watching my son run around eating a pumpkin donut with Frozen playing on the TV.

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Beautiful night for football. Go Buckeyes!
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Buckeyes game tonight with my dad. Go Bucks!
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Wheels up and heading back to Columbus. A great #AACRpan22 meeting in Boston. Great science, met a lot of people, and will definitely be back next year! @AACR @PanCAN @ZCMlab @Valentina_PitaG
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Senior graduate student, Debi Mukherjee, presenting her poster at #AACRpan22 meeting.
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On our way to to Boston for the @AACR pancreatic conference. Looking forward to a great meeting! @Valentina_PitaG @ZCMlab
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This September will try my patience. Wife is away all next week (single parent with toddler), following week big conference in Boston, and then submitting TWO R01 grants by October.

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First stop on vacation, stopped at a distillery where we could make our own bourbon mix. Named it “Wicked Curl”
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The 150th Open is being played at St. Andrews this week. I got to visit in 2017 on my honeymoon. Awesome experience to check off my bucket list. We were lucky, course is closed for golf on Sundays and anyone can walk course.
Impromptu lab outing to the Graeters ice cream truck outside our building.
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Future investigations into FcRn activity may further elucidate possible mechanisms of poor efficacy of antibody immunotherapies in patients with PDAC.
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