Following our recent breakthrough on mouse mini-intestines for ex vivo tumor development, we asked ourselves: can this technology be applied to cells from cancer patients? We are excited to announce the answer to this question in our latest publication: rdcu.be/dMuAr
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We’ve generated long-lived human ‘mini-colons’ that stably integrate cancer cells and their native tumor microenvironment. These are optimized for real-time, high-resolution evaluation of cellular dynamics.
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This system unlocks exciting experimental possibilities, such as the multi-faceted evaluation of drug efficacy, toxicity and resistance in anti-cancer therapies,

Jul 3, 2024 · 4:35 AM UTC

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the discovery of a cancer associated fibroblast (CAF)-triggered mechanism driving colorectal cancer invasion,
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and the identification of immunomodulatory interactions among different components of the tumor microenvironment.
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This work has been led by the brilliant @LFranciscoLM, with invaluable support from @NicoBroguiere, @JakobJLanger, Lucie Tillard, @mike_nikolaev, @CoukosGeorge, and Krisztian Homicsko. 🙏🙏!!
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