Institute of Human Biology (IHB), Roche, Basel, Switzerland. Institute of Bioengineering, EPFL, Switzerland. #organoids, #tumoroids, #stemcells, #bioengineering
Lausanne, Switzerland
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Bioengineered GI organoids just got an upgrade! Our new Transgel system combines 3D complexity with bilateral accessibility & remarkable observability, enabling advanced studies on tissue dynamics, stem cell niches, and host-pathogen interactions.🔬
👉 nature.com/articles/s41551-0…
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From gastric to colonic tissues: Transgel organoids replicate GI tissue architecture, including stem cell patterning and improved differentiation over time! There seem to be conserved mechanisms for geometry-induced stem cell organization and differentiation across the GI tract.
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Transgels enable live imaging of parasite infection in caecal models. Watch larvae invade epithelia in real-time & observe mechanisms like syncytial tunnel formation. Huge congrats to super talented @MoritzHofer_ and thanks to Maria Duque-Correa for the fantastic collaboration!
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Join us @Roche's Institute of Human Biology (IHB) as a Scientific Group Leader! Lead innovative research in #HumanModelSystems such as #Organoids. We especially seek applications aligned to our commitment to diversity and inclusion. More go.roche.com/11jc8 #TeamIHB #pRED
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Please join us in shaping the future of human biology research and help to translate it into real-world applications in pharmaceutical research and development!
📢Open call for Scientific Group Leads! #TeamIHB seeks stellar Junior & Senior scientists to start research groups on innovative and translational #HumanModelSystems. Expertise in #Immunology, #Neurology, #Ophthalmology, #Metabolism or #Oncology a➕! More go.roche.com/11jc8
ALT P-gp efflux transporters in the small intestine. Staining with immunofluorescence antibodies against the efflux transporter P-glycoprotein is in yellow. Its staining co-localizes with the marker villin (red) in the apical brush border of the epithelial cells that line the intestinal wall, creating an orange co-staining pattern.
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Fantastic paper that exemplifies the credo and mission of @IHB_Research: bold and creative young scientists as hands-on leads + projects combining biology, engineering, computation and drug development + extremely close collaboration between multiple research groups! Congrats!!
Exciting new inroads into human biology and therapy development: Human intestinal organoids with an autologous tissue-resident immune compartment! #Gjorevski #Cabon #IHB @Nature @IHB_Research nature.com/articles/s41586-0…
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Following our recent breakthrough on mouse mini-intestines for ex vivo tumor development, we asked ourselves: can this technology be applied to cells from cancer patients? We are excited to announce the answer to this question in our latest publication: rdcu.be/dMuAr
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and the identification of immunomodulatory interactions among different components of the tumor microenvironment.
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This work has been led by the brilliant @LFranciscoLM, with invaluable support from @NicoBroguiere, @JakobJLanger, Lucie Tillard, @mike_nikolaev, @CoukosGeorge, and Krisztian Homicsko. 🙏🙏!!
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Imagine growing a miniature version of the human intestine in the lab to study gut biology in great detail and test medicines before clinical trials? We are happy to share our latest publication on bioengineered human mini-intestines: authors.elsevier.com/sd/arti… Let’s dive in!
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These bioengineered mini-intestines are a powerful tool for exploratory and translational research. They enable advanced modeling of the intestinal #epithelial barrier for drug testing and capturing the multicellular complexity of gastrointestinal diseases.
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This project was spearheaded by @olga_mitrofan and supported by co-authors @mike_nikolaev, @_xuquan, @NicoBroguiere, Irineja Cubela, @GrayCampLab and Michael Bscheider as a collaborative effort between IHB, Roche pRED and EPFL. Huge thanks to all!!
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Thanks, this was a lot of fun!!
🤩The first Swiss Gut Workshop was a success! So exciting to dive into the latest gut research from organoids to the gut-brain axis, all set against the stunning Lavaux landscape🤩
🙏 to all participants for sharing amazing science and @UNIL for support!
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