Assistant Professor at @UPenn VetMed.Searle Scholar, Beckman Investigator. Development, reproduction, retrotransposons and gene editing. #Stem #FirstGen #BLM
Philadelphia, PA
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- Followers 936
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Andrew Modzelewski 🧬🐁🔬 retweeted
Happy Birthday to me!!
Check out our latest work led by a talented grad student @PatrickExconde
Here we developed a platform that allows us to generate new PRRs that convert protein degradation into a cell death phenotype, enabling functional genetics!
biorxiv.org/content/10.64898…
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Andrew Modzelewski 🧬🐁🔬 retweeted
Is single nucleus RNA-seq representative of single-cell transcriptomes and proteomes ?
This comparison shows that:
1⃣ Both scRNA-seq and snRNA-seq correlate weakly to single-cell proteomes.
2⃣ The correlation is much lower for snRNA-seq
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Andrew Modzelewski 🧬🐁🔬 retweeted
A new study reveals that parental age and assisted reproductive technologies affect de novo mutations in families. This highlights potential health implications and the need to refine reproductive practices. Read more: dlvr.it/TTxpZr
#ReproductiveHealth #Genetics
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Andrew Modzelewski 🧬🐁🔬 retweeted
Amazing photos from the #BeckmanSymposium taken by Corey Sandler of @oceventphotos
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Andrew Modzelewski 🧬🐁🔬 retweeted
Enjoyed reviewing and summarizing this important & reproducible (yes we tried it) paper on how DMSO is sufficient to induce human balstoids from human naive PSCs, emphasizing (again) the great importance cell state has on embryo models formed. Congrat to Mo Li group & @KAUST nature.com/articles/s41422-0…
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Andrew Modzelewski 🧬🐁🔬 retweeted
We’re incredibly grateful to Legal Sea Foods for their continued support of my lab at Boston Children’s Hospital. This year, Matt King, Brand President & COO, presented a donation made possible through proceeds from kids' meals at Legal Sea Foods. Thank you for your support!
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Dear Friends! Please VOTE-4-KATIE! My grad student Katie Toohill made it to the ProteinTech "Rising Research Award" final round! It would mean a lot to me and the lab if you voted for her (once a day!!) tinyurl.com/dzwmmr2e
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Andrew Modzelewski 🧬🐁🔬 retweeted
7 teams funded in final year of #Scialog: Automating Chemical Laboratories, co-sponsored by Beckman Foundation, Research Corporation for Science Advancement @RCSA1, and Frederick Gardner Cottrell Foundation. Congrats! Read the full announcement: rescorp.org/2026/07/7-teams-…
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Andrew Modzelewski 🧬🐁🔬 retweeted
Happy 250th America
"Without freedom of thought there can be no such thing as wisdom; and no such thing as public liberty, without freedom of speech.”
Hope those celebrating enjoy the day 🇺🇸 and the 🌎 World Cup games! 🇫🇷🇲🇦
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Happy 4th of July! 🇺🇸🦅🧨🎇. Here is televant Ben Franklin Maxim: "In wine there is wisdom, in beer there is freedom, in water there is bacteria." Stay safe out there today!
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Andrew Modzelewski 🧬🐁🔬 retweeted
Talked to staff in @SenMikeLee's office today about the OMB proposals that will change how grant decisions will be made. Thanks to Stand Up for Science for organizing the meeting. We all need to be doing what we can right now, in addition to making comments online. Link below:
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Andrew Modzelewski 🧬🐁🔬 retweeted
TODAY! Our second Summer Workshop on crafting and writing a research article - If you have not yet signed up, you can still register at the link below. You do not need to have attended the first session to join for the second!
Later this month, @NChanaday and I will be running this two-part WORKSHOP: Crafting & Writing a Research Article June 22, 2026 and June 29, 2026 4 pm – 6 pm Zoom (link provided after registration) Sign up: forms.gle/ZDHsrxjJWung...
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Andrew Modzelewski 🧬🐁🔬 retweeted
🧬Happy Transposon Day!🧬
Each year on the 16th of June we commemorate Barbara McClintock's birthdate, this year we've compiled quotes from various members of the Mobile DNA community on the life and legacy of McClintock.🌽
Check out the blog here:
go.nature.com/4v2I4Hu
ALT McClintock with an ear of corn. From Wikimedia: Cristian472735 CC BY-SA 4.0
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Great publication by our former Postdoc Nick (Chun) So, now PI at NIBS.
Congratulations to So Lab @SpermnOocyte and the team! 🥳
Why 50% of human fertilized eggs fail to complete pre-implantation development?
Latest work from my lab in @CellCellPress now clarifies the two causes that contribute to the low efficiency of early human embryos and provides one of the solutions. (1/7)
doi.org/10.1016/j.cell.2026.…
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Andrew Modzelewski 🧬🐁🔬 retweeted
Later this month, @NChanaday and I will be running this two-part WORKSHOP: Crafting & Writing a Research Article June 22, 2026 and June 29, 2026 4 pm – 6 pm Zoom (link provided after registration) Sign up: forms.gle/ZDHsrxjJWung...
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Andrew Modzelewski 🧬🐁🔬 retweeted
Excited to share that our preprint 'RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription' is now online @MolecularCell cell.com/molecular-cell/full… @PennMedCSO @PennCancer @PennEpiInst
(1/n) Excited to share our new preprint! We uncover that RNA actively promotes nucleation and function of pathogenic condensates, amplifying locus-specific oncogenic transcription and promoting tumorigenesis. #epigenetics #condensates #cancer #RNA biorxiv.org/content/10.1101/…
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What happens inside human egg cells as they age, and why are errors so common?
In the new episode “Ach, Mensch!” of @detektorfm (in German), Melina talks about fertility, ageing egg cells, future fertility treatments and the motivation behind her research.
detektor.fm/wissen/ach-mensc…
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