Cancer Systems Biology
Weizmann Institute of Science
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Tirosh Lab retweeted
IDH-mutant gliomas often progress slowly, but inevitably recur and progress. Are there spatial organizing principles at the level of cell states that repeat across tumours during stages of tumour progression?
cell.com/cancer-cell/fulltex…
Out this week in @Cancer_Cell, our work with @RouvenHoefflin, @TiroshLab, @MarioSuva, @GaliliNoam, and Christopher Mount quantitatively maps two independent axes of tumour organization, revealing how they emerge at different stages of progression and in distinct tissue contexts. We hope that understanding these recurring spatial patterns and associations will reveal new opportunities to halt tumour progression.
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Tirosh Lab retweeted
🧵1/ Happy to share our new study:
"Spatial analysis reveals the evolving organization of IDH-mutant glioma"
We asked: How is spatial organization established in glioma before the hypoxic architecture of advanced disease emerges?
cell.com/cancer-cell/fulltex…
ALT Graphical Abstract
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Excited to share our new paper in @NatureGenet!
Using spatial transcriptomics and proteomics, we uncover two tumor-wide modes of partial EMT (p-EMT) in head and neck cancer, at the tumor edge or core, with distinct microenvironmental drivers. 🧵 (1/14)
nature.com/articles/s41588-0…
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Take-home model:
Tumor edge → fibroblasts / TGFβ → interface p-EMT
Tumor core → myeloid cells / OSM-OSMR → intratumoral p-EMT
Spatial context can separate biologically distinct versions of a state that may look similar in dissociated or bulk data. (13/14)
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A collaborative effort between our lab at @WeizmannScience and the Puram Lab (@SidPuram) at @WUSTLmed, co-led by Dor Simkin and Tom Barrett. Many thanks to all authors for their contributions!
#SpatialTranscriptomics #HNSCC #Visium #CODEX #EMT (14/14)
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Registration for the Gordon Research Conference (GRC) in Single-cell cancer biology is now open! It will take place March 22-27, 2026, in Ventura, CA.
For more info and registration:
grc.org/single-cell-cancer-b…
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Congrats Alissa!!
Highly recommended for students
I'm thrilled to share that I'll be starting my lab (greenwald-lab.org) at the Lunenfeld-Tanenbaum Research Institute @SinaiHealth and joining @MoGen_Grad at the University of Toronto as an assistant professor this fall. 1/
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Tirosh Lab retweeted
👉The Curated Cancer Atlas.
Impressive: “124 scRNA seq datasets for >40 cancer types, with improved data annotations, visualizations and exploration”.
From Michael Tyler and @TiroshLab
@WeizmannScience
nature.com/articles/s43018-0…
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Tirosh Lab retweeted
Important publicly available resource from @TiroshLab @WeizmannScience in @NatureCancer
The Curated Cancer Cell Atlas provides a comprehensive characterization of tumors at single-cell resolution
nature.com/articles/s43018-0…
124 single cell datasets across 40 cancers, >2800 samples.
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