Professor & Dattels Family Chair at The Jackson Laboratory @jacksonlab studying hematopoietic stem cell biology, aging & cancer. 🇨🇦🇺🇸 Tweets are my own.
Bar Harbor, Maine
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Bittersweet to say goodbye to our lab manager @griffin_nye after 5 years. He's kept the lab running & brought endless enthusiasm along the way. So grateful for all he's given. I'll miss him, but I'm excited to see him follow his dream of becoming a teacher! 🩷
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I had the privilege and joy of returning yesterday to the @DanaFarber and @BostonChildrens where I did my postdoctoral training, this time as an invited speaker. Grateful to Zuzana Tothova for hosting me! It was a full circle moment and can't wait for the next time 😁
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With mixed emotions, we said farewell to our summer student Eva Rios. She was a JOY to have in the lab - thoughtful, engaged, creative, a dot-connector and with a great sense of humor and desire to learn and be challenged 🤩 #SSP26 #JAXGenomicEducation #JAXstemcellsdev
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Clearing senescent MSCs at the CH stage delayed progression to AML and extended survival. Targeting the niche, not just the mutant cells themselves, slowed malignant evolution.
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Correlation isn't causation, so we tested it 3 independent ways: genetic depletion of p16-hi cells (p16-3MR mice), the BCL2/BCLxL-targeted ABT-263, and senolytics dasatinib + quercetin. All three depleted senescent MSCs and shrank Dnmt3a-mutant chimerism in vivo.
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Mechanism: Dnmt3a-mutant HSPCs secrete TNFα and IL-6 that selectively activate Stat3 and ROS in MSCs, driving p53/p21-dependent senescence. Blocking TNFα, IL-6, or Stat3 each prevented it.
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Buried in Fig. 2 but important: transplant conditioning (irradiation/busulfan) can be a confound. Using non-conditioned transplants, we show mutant clones still gain a fitness edge with natural aging, the first demonstration that Dnmt3a-mutant clones can do this.
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MSCs from Dnmt3a-mutant mice show upregulated p53 targets, ROS, SASP, and senescence signatures, and the same signal shows up in human bone marrow MSCs from CHIP carriers across 4 different driver mutations (DNMT3A, TET2, ASXL1, CCAR1).
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We ran scRNA-seq across non-hematopoietic bone marrow populations (MSCs, osteoblasts, endothelial cells) in mice with Dnmt3a-mutant vs. control hematopoiesis. One population stood out: mesenchymal stromal cells (MSCs) had the most changes, dominated by a senescence signature.
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A huge congratulations to the newest graduate of the Trowbridge lab, Dr. Shawn David!! Shawn did a fantastic job defending his thesis today. So proud! 🎉 👏 🎊 #JAXGenomicEducation #UMaineGSBSE #JAXresearch #JAXstemcellsdev
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#ISSCR2026 is a wrap - so what's next? 🔬
The JAX-NYSCF Conference
Sept 23–24 | The Rockefeller University, NYC
Fabulous program and registration is open! See you there!!
conference.nyscf.org/
#JAXresearch #JAXstemcellsdev
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1/3 Delighted to have visited @UPenn this week, hosted by the fantastic Dr. Bobby Bowman who has built an exciting research program on the origins of myeloid malignancies and leukemia relapse.
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⏲️The clock is ticking.. submit your abstract to the @ISEHSociety annual meeting by April 17th. Join us and be (re-)introduced to this awesome group of leading hematologists/stem cell biologists in a close-knit environment where you will receive in depth feedback on your work!
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On my way home from #EHAReCon2026 in Helsinki having caught up with old friends, met fantastic new colleagues and bright trainees, learned new things and now full of new ideas! Thanks @EHA_Hematology!
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Fun lab lunch & farewell to postdoc @jaynathemistry as she leaves us to start her own lab @uniofeastanglia @NorwichMedED!! 🎉 Watch this space - Jayna is a creative and passionate scientist, can't wait to hear about her lab's big discoveries 🤩
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It was such an honor to receive a Scholar achievement award from @BloodCancerUtd last night at the @ASH_hematology annual meeting. With deep gratitude to my colleagues, friends and mentors who took time out of their busy schedules to attend the reception 🙏 1/n
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My son had the best time at Flagg @ProCamps basketball camp! Watching Cooper, Ace & Hunter 2v2 on the court was hilarious & grounding. At the end of the day, the kids took away important lessons - work hard, have fun, love your family & be grateful! @Cooper_Flagg @kflagg11
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The annual Trowbridge lab mini golf tourney! Newest lab members are team captains & pick their team & theme. Thanks to Margaret, Natalie & Kayla we had team Goldilocks, team pro golfers & team goth. As you likely guessed, the pro golfers won! 🏆 Always a blast with this crew!
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Grants submitted, paper submitted, experiments on pause... taking a break and getting out into our backyard National park! E-bikes for the win 🙌
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We find that MitoQ also targets elevated mitochondrial respiration and the selective advantage of human DNMT3A-mutant HSCs, supporting species conservation.
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Exploiting elevated mitochondrial membrane potential, we used long-chain alkyl-TPP molecules (ex. MitoQ) that selectively accumulate in the mitochondria. These caused reduced mitochondrial respiration, apoptosis, and ablated the competitive advantage of Dnmt3a-mutant HSCs.
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Dnmt3a-mutant HSCs have DNA hypomethylation and increased expression of oxidative phosphorylation gene signatures, increased functional OXPHOS capacity, high
mitochondrial membrane potential & greater dependence on mitochondrial respiration versus wild-type HSCs.
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Using a mouse model of Dnmt3a-mutant CH that our lab previously developed, we found that mutant HSCs sustain elevated mitochondrial respiration which is associated with their resistance to aging-induced changes in the bone marrow microenvironment.
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Happy holidays from the Trowbridge lab! 🎄the festive games got a little bit competitive this year 😅
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Lastly, a shout out to my co-chair @srpasricha for a lot of laughs, for keeping an at-times challenging job light and fun, & for literally sharing the spotlight with me. Wouldn't have wanted to partner with anyone else. Hope to see everyone at #ASH25!
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#ASH24 badge has arrived ✅ @srpasricha and I are delighted & excited to see everyone in San Diego. Getting ready for Best of ASH! During the meeting, stay tuned for posts about sessions you do not want to miss. 😎
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Feeling all the emotions this year 😁 Happy Halloween from the Trowbridge lab Inside Out! 🎃
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Last but not least, Garrett’s popcorn ✅ Riding off into the sunset. Farewell Chicago! #Iseh2024 was a scientific and culinary treat! @ISEHSociety
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Chicago donut at Do-Rite ✅
We have something similar at home! If you are ever in Northeast Harbor, Maine on Mount Desert Island get a donut at Colonel’s Bakery for a compare and contrast! 🍩 @ISEHSociety #ISEH2024
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Enjoyed a fantastic meal at Michelin-recognized The Purple Pig. Including bone marrow… how could we not? But above all, the company was unbeatable. #iseh2024 @ISEHSociety
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Outstanding work, very clearly presented and provocative! Feeling inspired. Congrats Helena and @SignerLab!
Loss of proteostasis is a hallmark of aging…but did you know that it is also severely challenged during development? This morning at #ISEH2024, rising star Dr. Helena Yu will tell you how developing stem cells meet these challenges & its impact on the future of transplants.
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Deep dish pizza ✅
With super spicy peppers for @rschneiderlab ✅
Other than donuts, what do I add to the list for Chicago foods?! @ISEHSociety #ISEH2024
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Chicago-style hot dog ✅
Tater tots with spicy toppings ✅
Up next: deep dish pizza @TheElfLab recommendations for best pizza downtown, please! #ISEH2024 @ISEHSociety
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Delighted to get the lab together for a barbecue. Missing a few folks that couldn’t make it. What I love about this team is that they are as proud of and committed to each others’ successes as they are for their own. They spark joy! 🤩
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Taking off my science hat to wear my mom-of-a-kid-that-loves-basketball hat. Cooper & Ace Flagg Basketball Camp! @ProCamps @Cooper_Flagg @FlaggAce @bangorsavings
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Delighted that Kira Young's work made the cover of @BloodJournal @ASH_hematology!!! authors.elsevier.com/a/1jUXn… 😍 A beautiful image taken by collaborators @johannaHfmann98 @kd_kokkaliaris. Thank you Adam MacLean & Lenhard Ruldoph a fantastic writeup: sciencedirect.com/science/ar…
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The "don't remember - 10th maybe?" annual Trowbridge lab mini golf tournament was a resounding success. Team Glitter and Gemstones for the win!! 👏🏆👑
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When in Houston… there are so many outstanding scientists to catch up with! It was fantastic to spend some time with Katherine @TheKingLab and JAK2 superstar Andy Dunbar!
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Learning more about health disparities in hematologic malignancies thanks to @MDAndersonNews @WeillCornell. Interfacing with clinical researchers & patient advocacy groups & presenting our work on discovery science using diverse mouse populations. Feeling inspired!
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Science Olympiad National Tournament #SON2024. Conners Emerson School representing the State of Maine! Let’s go!!!! 🎉 #proudmomofscientists
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Smarties for these smarties 🎉 celebrating our postbacc Cameron Keeley-Parker on rocking his MCAT exam and PhD candidate Shawn David on passing his qual exam with flying colors. Can’t wait to see the awesome scientific discoveries that these two will make!!
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A bit surreal but awesome to be back @westernuMNI with many faculty that I used to listen to in lectures now listening to me. I found my thesis in the cabinet! Wish I could read the one next to mine: “Studies of an unidentified organism” from 1952. Whoa.
On a tiny plane on my way to my alma mater @WesternU @westernuMNI @SchulichMedDent to give a seminar on our lab’s latest work in hematopoietic stem cell biology and aging. If you are on campus tomorrow (Thurs) at 11am, we will be in dental sciences DSB 3008. Join us!!
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On a tiny plane on my way to my alma mater @WesternU @westernuMNI @SchulichMedDent to give a seminar on our lab’s latest work in hematopoietic stem cell biology and aging. If you are on campus tomorrow (Thurs) at 11am, we will be in dental sciences DSB 3008. Join us!!
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Although inflammation has emerged as a regulator of hematopoietic aging, we saw no evidence that expression of pro-inflammatory cytokines like IL1b, IL6, TNF & RANTES directly predicted HSC signatures. Since we studied middle-aged mice, this may be different in old age...
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Functional validation of our predictions concludes that lower expression of Kitl (SCF) and Igf1 in mesenchymal cells predicts reduced lymphoid lineage commitment of HSCs & accumulation of differentiation-inactive HSCs. Unexpectedly, Kitl and Igf1 are correlated & co-regulated!
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Of all cell types profiled, hematopoietic stem cells had the most phenotypic variation between middle-aged mice. Harnessing the power of matched pairs, we computationally determined which regulatory cell types & factors predict variance in HSCs between individual mice.
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Delighted to share our new work in @BloodJournal led by the outstanding and creative Dr. Kira Young! Kira embarked on a journey to understand why individual organisms exhibit natural variation in hematopoietic aging phenotypes. Interesting question! doi.org/10.1182/blood.202402…
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Two days of planning #ASH24 in the books. It’s shaping up to be an awesome meeting - you won’t want to miss it!! Thanks to the scientific committees for making my job easy 🤩 My scientific program co-chair @srpasricha & I took a walk around DC to celebrate 🎉
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Thanks to @iannisaifantis1 for the #ASH23 restaurant recommendations! We ventured to Fort Oak for dinner last night. Delicious, creative, great atmosphere, superb company! @jaynathemistry @Dr_YoungBlood @griffin_nye
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A wonderful lab dinner with current and former Trowbridge lab members. So grateful for them!!! #ASH23 @jaynathemistry @Dr_YoungBlood @griffin_nye @Captainsnehab
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Super proud of @jaynathemistry representing the lab and her awesome work on senescence in the bone marrow microenvironment & clonal hematopoiesis in Friday’s Hemarology & Aging workshop!! 😎 #ASH23
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Following the sunrise all the way to the west coast. Excited for science, friends and fun at #ASH23!
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And a huge CONGRATS! to @jaynathemistry for receiving an ASH abstract achievement award this year 🙌
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My lab is so excited for #ASH23 they got a head start to San Diego early this morning! 😎 New work will be presented by @jaynathemistry @Dr_YoungBlood & Shawn David (collab project w/ @vangalenlab). Abstracts below! I arrive Friday - PM me to chat. Trainee positions available!
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Fantastic day sharing science & technology ideas & inspirations, good food, fresh air & exercise at our lab retreat. So lucky to work with this fabulous group of people!!! @jaynathemistry @Dr_YoungBlood
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Happy Halloween from the Trowbridge lab! Blood and bones; vampires and skeletons. Inspired by @theclotthickens 🩸🦴🩸🦴
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Last week I visited @cohesinlab @CSCIColumbia for in depth conversations about scientific projects & career development. While enjoying amazing food in NYC! So impressed by @TheDoctorIsVin’s leadership & mentorship. Can’t wait to see the great things this team will accomplish!!
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Thank you @Columbia Dept of Ophthalmology for inviting me to speak at the Abraham Spector Prize Symposium, awarded this year to the pioneering investigator Tom Rando. Fun to hear great science from Tom, Manu Passegue, @ohyilmaz and others @CSCIColumbia!
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Congratulations to our newly minted PhD Dr. Logan Schwartz!! @Logan_Schwartz1 🎉🎉🎉 Very proud of your accomplishments and excited for the beginning of your next chapter… can’t wait to see what’s in store! 🥂 @JAX_Education @jacksonlab @TuftsGSBS
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