Account of the Chromatin, cancer and the ubiquitin system lab, based in the CBM. Focus on DNA replication dynamics, ubiquitin, SUMO and cancer.
CBM, CSIC-UAM - Madrid
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Sigue abierta la inscripción para el Simposio, tanto para asistir como para presentar un póster o una charla corta. ¡Os esperamos!
📢 Ya está abierto el plazo de inscripción para el II Chromatin Alterations in Cancer Development Symposium, que será el 28 de septiembre en el CBM. Organizado por nuestros investigadores @AnaOrtegaMolin1 y @Emlecona.
🗓️ Deadline para inscribirse: 9/9/26
cbm.uam.es/index.php/events/…
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Congrats @rodrimartinr on your great thesis defense and thanks to María Villa, AnnaMaria Ruggiano and Jim Sutherland for their work as Thesis Committee. Rodrigo is the first PhD from the lab and we cannot be prouder of his great work. All the best in your future career!
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It was a great honor to host Keith Caldecott at the @CBM_CSIC_UAM
Thanks for a very inspiring talk.
Hemos tenido el placer de recibir a Keith Caldecott en el CBM. Su charla abordó el papel de la actividad PARP en la reparación de roturas de ADN y su impacto en enfermedad humana, y los mecanismos clave para mantener la estabilidad del genoma y entender patologías asociadas.
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We propose a semi-distributive model for priming in the lagging strand that sets the RSR in a DNA replication control mode (DRC). The DRC modulates the progression of DNA replication through S phase to ensure the maintenance of genomic stability.
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Fresh from the oven! Our new perspectives article where we discuss the interplay between lagging strand DNA replication and the replication stress response.
An updated view on lagging strand DNA replication: implications for the replication stress response tandfonline.com/doi/full/10.…
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Congrats Alicia on the best poster prize in the PhD & Postdoc Annual Meeting @CBM_CSIC_UAM
Very proud of you! Many more successes to come!
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We are looking for a candidate to apply for a postdoctoral contract in the Juan de la Cierva 2025 call, to join our lab at the @CBM_CSIC_UAM to work on the interplay between the ubiquitin pathway, DNA replication and the replication stress response.
Aprobada la convocatoria Juan de la Cierva 2025 (#JDC2025) para fomentar la incorporación de jóvenes doctores/as y completar su formación postdoctoral en centros de I+D.
▶️500 ayudas
💵60 M€ (+21,7 M€ que 2024)
📅Plazo: 25 nov-10/17 dic 2025
📰aei.gob.es/noticias/agencia-…
#FSE+
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Very proud of @rodrimartinr showing his work his awesome work.
Regulation of DNA replication and the replication stress response by ubiquitin and VCP/p97 por @rodrimartinr de @UbiSystemLab @CBM_CSIC_UAM #47congresoSEBBM
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Still looking! Please spread the word.
We are looking for a candidate to apply to a #MSCA Postdoctoral Fellowship in our lab in the @CBM_CSIC_UAM, working on the connections between DNA replication dynamics, replication stress and genomic instability in cáncer. Contact us if you are interested and please retweet.
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We are looking for a candidate to apply to a #MSCA Postdoctoral Fellowship in our lab in the @CBM_CSIC_UAM, working on the connections between DNA replication dynamics, replication stress and genomic instability in cáncer. Contact us if you are interested and please retweet.
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Huge thanks to all people involved, @SMOA_CBM and flow cytometry facilities from @CNIOStopCancer and @CBM_CSIC_UAM.
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So, to sum up: VCP/p97 ➡️ POLA/PRIM on chromatin ➡️ priming ➡️ basal RSR activation! This work was led by @Emlecona from @CBM_CSIC_UAM in collaboration with @JMendez_DNA from @CNIOStopCancer. Want to dive a little bit more in our work? Click this link! rdcu.be/eu1yo
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Fresh from the oven! Ever wondered how cells keep ATR activation controlled during normal DNA replication? Our last paper in @NatureComms shows that they do it by extracting POLA/PRIM from chromatin using VCP/p97! Still curious? Take a look...🧵🧵🧬🧬
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Today we celebrated #EuropeDay2025 showing the work of @FateRepli and how the European Union helps to build strong science.
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The @CBM_CSIC_UAM is looking for #postdocs ! If you are interested in joining our lab to work on DNA replication, cell fate and cancer, contact us!
For more information, check our website cbm.uam.es/elecona !
#sciencejobs
📢¡We are launching the CBM Postdoctoral Call!
Join us for great science, a friendly atmosphere & fantastic conditions with one of these 6 x 3-year positions.
🗓️Deadline: 30/9/24
ℹ️How to apply: bit.ly/postdoccall
📩Questions? postdoctoralcall@cbm.csic.es
#postdoc #jobpost
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This entire week Scott Churcher from our lab has enjoyed a training course on Microscopy and Quantitative Imaging held in the Institute of Epigenetics and Stem Cells, in Munich at the Helmholtz Center thanks to @FateRepli doctoral Network!
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Yesterday we had the pleasure to hear @rodrimartinr explain part of his work in the lab to the audience present at this event! #PINT24MAD #PINT24ES
Thanks for the organization and the opportunity @pintofscienceES 🎉
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Our lab is going to participate in Pint of Science in Madrid!! #Pint24MAD @CBM_CSIC_UAM @pintofscienceES
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Hi everyone! This is the Twitter account of Emilio Lecona's lab in @CBM_CSIC_UAM. Let's start!
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