VEGF plasmid therapy is available on Roatan and in Mexico. The Follistatin + VEGF Combo safety trial is recruiting.
Roatan, Honduras
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Unlimited Bio retweeted
Several people asked to see before and after, rather than just the treated side versus placebo.
The difference looks pretty striking. But this shows the result of the entire regimen: VEGF gene therapy, minoxidil, finasteride, dutasteride, red light and scalp care.
The treated-side vs placebo-side comparison helps assess what VEGF may have added on top of everything else.
Six months ago, I injected VEGF gene therapy into one half of my scalp and a placebo into the other. But the goal was more ambitious than simply outperforming the control.
Across my entire scalp, I was using what I considered the best available hair-growth protocol: minoxidil, dutasteride, finasteride, red light, and additional treatments. Gene therapy had to deliver on top of that combination, not replace it.
Six months later, across two areas without hair transplants, hair density on the VEGF-treated side was, on average, 20% higher than the control, with 62% of hairs in the growth phase versus 50%. At the back of my scalp, average hair diameter increased by 12%, while it decreased by 9% on the control side.
This is a one-person experiment, and the findings need to be confirmed on a bigger population. But for me, it’s a breakthrough. That’s what REAL biohacking and gene therapy are about: taking the best of what’s available—and trying to go beyond it. Not just repeating what’s already been achieved, but expanding human potential.
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Unlimited Bio retweeted
5 steps to make any cancer curable:
1. early complex diagnostics
2. maximize individualization
3. maximize combinations
4. do all of the above fast
5. repeat
The tragedy is that cancer might already be curable, but we fail as a society to address it because we’re too busy optimizing likes and views on social media.
Cancer changes. Measure it, adapt the treatment, hit it again. Repeat until it’s gone. Do it with no delay.
We should start offering individualized combinatory cancer solutions in Próspera.
What accessing frontier cancer care looks like in 2026:
-Go through 1-2 years of standard of care (poison/slash/burn - original poster forgot radiation and hormone suppression). You’re only a good candidate for a vaccine if you are cancer free or have minimal residual disease.
-Hire PhDs / Lawyers to fight with your hospital for your tumor tissue, which is likely stored in a way that makes sequencing it hard / impossible
-Pay $50K+ to sequence your tumor tissue
-Pay $1M+ for a custom immunotherapy / vaccine with no efficacy or safety info
-Find an oncologist and medical setting to sponsor this plan, the biotechs that made you the drug can’t administer it and you’ve likely alienated your actual oncologist by now
-Hire lawyers: Petition the FDA for an n-1 clinical trial or relocate to Germany (or maybe Montana) to take vaccine series
-Take the series. You won’t actually know if it worked (no data) so you monitor all your markers constantly with ctDNA and other testing to search more therapies and to see if the vaccine activated your immune system and worked.
There’s a lot of promise here and people who can access frontier cancer care are so fortunate. Every cancer patient wants every chance they can get. But it’s bs to say we’ve solved cancer in 2026.
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Unlimited Bio retweeted
Ooh, neat.
This gene therapy might be helping with hair loss👀
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Unlimited Bio retweeted
Six months ago, I injected VEGF gene therapy into one half of my scalp and a placebo into the other. But the goal was more ambitious than simply outperforming the control.
Across my entire scalp, I was using what I considered the best available hair-growth protocol: minoxidil, dutasteride, finasteride, red light, and additional treatments. Gene therapy had to deliver on top of that combination, not replace it.
Six months later, across two areas without hair transplants, hair density on the VEGF-treated side was, on average, 20% higher than the control, with 62% of hairs in the growth phase versus 50%. At the back of my scalp, average hair diameter increased by 12%, while it decreased by 9% on the control side.
This is a one-person experiment, and the findings need to be confirmed on a bigger population. But for me, it’s a breakthrough. That’s what REAL biohacking and gene therapy are about: taking the best of what’s available—and trying to go beyond it. Not just repeating what’s already been achieved, but expanding human potential.
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Morgan described all the major reasons why we started Unlimited 2.5 years ago: 1) pace of experimentation; 2) approval hurdles; 3) lack of combination approaches
A lot of people are rightly pointing out that the pace of experimentation and regulatory approval are major hurdles to AI-driven impact on disease.
But I think there’s a deeper issue.
We haven’t fundamentally evolved how we think about treating disease.
The dominant paradigm is still largely: find a target → develop a drug → run a clinical trial → get approval.
But even if we solved the experimentation and regulatory bottlenecks and AI massively accelerated the end-to-end pipeline, would that revolutionize human health?
Probably not.
For most major chronic diseases, there isn’t a single cause or target (there certainly isn’t for aging) and we’ve had remarkably little success curing these diseases.
Yet we continue plowing ahead with the therapeutic pipeline built around finding a target and developing a drug against it. That will never be enough.
Instead, AI should be used to do more than accelerate this existing process. It should allow us to meet biological complexity head-on and think about entirely new ways of treating disease.
If we want to realize the promise of curing diseases that today seem intractable, we have to be brave enough to disrupt the paradigm at its foundation.
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Reason speaks on his participation in CALM-AF-AI AAV Follistatin trial in GARM Clinic in Prospera.
The first half of participants get AAV Follistatin monotherapy and the second half gets intramuscular injections of both AAV Follistatin and VEGF plasmid therapy.
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Unlimited Bio retweeted
Great conversation between Reason and Niklas Anzinger on the FDA, GMP, and why clinical trials have become so slow and expensive.
Plus of course Reason’s firsthand experience receiving AAV-follistatin as part of Unlimited Bio’s clinical trial in Próspera.
piped.video/x6tCq-eVwyA?is=C_P-…
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Unlimited Bio retweeted
Another reason why we administer the VEGF165 plasmid intramuscularly
Freedman et al. prospectively measured plasma VEGF in 64 patients after VEGF plasmid gene transfer, including 34 patients who received direct intramuscular injections. In the intramuscular group, median plasma VEGF increased only slightly from 38 to 41 pg/mL on day 7 and was no longer significantly different from baseline on days 14, 21, or 28.
VEGF165 isoform binds to heparan sulfate and components of the extracellular matrix, allowing much of the expressed protein to remain within the muscle near the injection site, with relatively little entering the systemic circulation. Tissue retention differs between VEGF isoforms: VEGF121 is more freely diffusible, VEGF165 occupies an intermediate position, and VEGF189 is retained even more strongly within tissues.
The authors cite two glioblastoma samples in which tissue VEGF concentrations exceeded 7,000 pg per mg of protein, while simultaneously measured circulating levels were only 23–40 pg/mL.
Therefore, intramuscular administration of a VEGF165 plasmid is intended to produce a predominantly local effect without substantial systemic VEGF exposure. That is the point of this delivery strategy.
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Unlimited Bio retweeted
Why I Believe We Cannot Solve Aging Without Solving Cancer
We want to extend telomeres, but there is a risk of cancer.
We want to improve capillaries with VEGF, but there is a risk of cancer.
We want to regenerate the thymus with growth hormone, but there is a risk of cancer.
We want to use epigenetic reprogramming, but there is a risk of cancer.
Whatever we try, there is a risk of cancer.
Cancer ties our hands. If cancer were no longer a problem, we could test interventions faster, learn what works, and move much more quickly toward solving aging.
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Why do we still accept loosing people around us from cancer? Why can't even terminal patients freely access experimental treatments?
Consider personalized cancer vaccines, none of which are yet on the market. How many years will it take to approve a vaccine for each cancer type? People with advanced cancer do not have years. Every day matters.
Unlocking breakthrough treatments is what Unlimited Bio was built for. DM us about your case and we'll see what we can do!
Following a successful fundraise for this program, we intend to sponsor treatment in Próspera for at least one eligible patient. Others will be offered access on the most favorable terms we can provide.
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Unlimited Bio retweeted
The hot new argument against even running clinical trials of certain gene therapies is that the patients involved might develop immunity to the delivery method, preventing them from taking future gene therapies with the same delivery.
So let's never test gene therapies.
Hurray!
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Unlimited Bio retweeted
Are we headed toward a future where, instead of all those oxygen tanks, Everest tourists will just inject themselves with gene therapies?
What’s established is that genes do matter at high altitude. The Nepalese Sherpas - an ethnic group known as mountain guides in the Himalayas are the brightest example.
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Thank you, everyone, for your trust! Your applications are being processed. We haven't sent that many rejections yet, but potential participants who are preliminarily eligible have been contacted. Check your mailbox, including your spam folder, in case you filled in the form.
We’ve crossed 100 completed prescreening forms for our clinical trial combining two gene therapies.
This is the world’s first clinical trial of a gene therapy combination for longevity.
Over 100 organic applications for a trial with only 12 participant slots.
We didn’t use CROs or any similar recruitment mechanisms.
Which means people genuinely want access to advanced therapies, not someday in an abstract future, but right now.
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Unlimited Bio retweeted
We’re often not even invited to speak at longevity conferences because we’re seen as too weird and too controversial.
But when we do get the chance, people realize there’s something there.
Our field must remember: you don’t get new results by doing old things. We need radical change. Unlimited Bio is one small example.
This was next level. 28 companies presented bold ideas shaping the future of longevity and biotech at VB26!
A special congratulations to the winning companies:
🏆 Unlimited Bio (@vladileshko )
🏆 Frontier Bio (Eric Bennett)
🏆 Sundial Therapeutics (Nakoa Israel Po)
🙌
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Unlimited Bio retweeted
So far, we’ve raised $600K.
We got combination gene therapy into the clinic.
With $1M, we can do the same for both: gene-therapy-based partial reprogramming and partial chemical reprogramming — the latter potentially being a safer option.
It’s cool that the field has so much funding.
I have nothing against partial reprogramming. But what if it doesn’t work? We could waste billions and a couple of decades on one hypothesis, and end up with nothing but investors disappointed in the field — the same thing that happened with antioxidants, senolytics, telomeres…
If the goal is not just to make a lot of money on the next IPO, but to really solve the problem while the people we love are still alive, we should test multiple hypotheses and their combinations simultaneously — quickly and cheaply.
Following breakthrough results, we’re bringing longevity medicine to human trials.
We’ve raised a $435M Series C led by @foundersfund to make it happen.
Reprogramming cell age has the potential to create more healthy years for everyone. We're closer than ever to realizing it.
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Vasculature restoration with VEGF plasmid gene therapy in a CLI stage IIb patient.
Before and 6 months after.
2 sessions of 20+ i/m injections in each leg.
#vegf #pad #CriticalLimbIschemia
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Sticking to FDA-approved enhancements won't get you far.
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A night to remember! #EnhancedGames
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