Clinical Computational Oncology @DanaFarber @harvardmed @broadinstitute | Chief - Population Sciences | Prev.: @Stanford @UCLA @UCSF | Discl.: bit.ly/2kF9C7B

Boston, MA
There’s never been a more exciting time for all of us to take on cancer, together.
Reminded today of how lucky I am to work with a multi-ethnic/racial/gender/religious/national team united in the fight against cancer
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In case anyone is running agents and wondering if you can leave them running on a holiday, know that Chabad is on the case! chabad.org/library/article_c…
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New work from Pasi A. Jänne, us, and 23andme; led by Jackie LoPiccolo and Steven Micheletti. Characterizing a highly penetrant germline founder mutation for lung cancer.
An inherited genetic mutation may increase lung cancer risk among people who have never smoked, according to a new Science study. By tracing the ancestry of people carrying the rare EGFR T790M variant, researchers uncovered a shared genetic legacy extending back hundreds of years and concentrated in the southeastern United States. Learn more in this week’s issue: scim.ag/46q1kUC
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In our latest, we continued multi-omic exploration of GI neuroendocrine tumors, finding potential organ-specific molecular programs and microenvironmental niches - congrats Julie Karam @SamHoffmanMed et al! @DanaFarber @broadinstitute @jclinicalinvest jci.org/articles/view/204119
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🚨We are hiring! 🚨 The Department of Biostatistics @HarvardChan and the Department of Data Science @DanaFarber are recruiting a tenure-track Assistant/Associate Professor in statistics or machine learning with interests in single-cell or spatial genomics. Link below 👇
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Very exciting new method for inferring latent disease trajectories, led by the tireless Dr. Urbut with Natarajan and Parmigiani labs. If you're considering a postdoc in this area talk to Sarah!
One of my first consults as a cardiology fellow: a 34-year-old, textbook MI. A day earlier, no risk model would have flagged him for prevention. That paradox has driven my work ever since — our models miss how disease actually evolves, dynamically, on top of a genetic background. @Nature nature.com/articles/s41586-0…
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One of my first consults as a cardiology fellow: a 34-year-old, textbook MI. A day earlier, no risk model would have flagged him for prevention. That paradox has driven my work ever since — our models miss how disease actually evolves, dynamically, on top of a genetic background. @Nature nature.com/articles/s41586-0…
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📣Delighted to share two new studies from our team using germline genome sequencing 🧬 to understand #cancer #predisposition! Interested? 🧵👇 for details 1/15
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RT @NaturePortfolio: Using burgers as a model system, a generative AI system rediscovers the classic Big Mac without explicit supervision a…
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1/ Results from #ARC20 trial are out in @Nature! This trial evaluated the HIF-2α inhibitor Casdatifan in heavily pretreated advanced ccRCC and provides important insights into HIF-2α biology and response. This is the 2nd HIF2 inhibitor with enough activity to move to a pivotal study after Belzutifan, cementing the 2019 @nobelprize story with @kaelinlab et al Check it out: nature.com/articles/s41586-0…
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In our latest, we tested elements of cancer biology research using @AnthropicAI AI agents, with varying amounts of human involvement across multi-step, multi-omic analyses Interesting times for agentic AI & biological discovery, and for the future of (cancer) biology research...
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I just went 82-0, think you can go 82-0? 82-0.com/share?id=sa8BjbXwVE… #NBA #82and0
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We are hiring! We are specifically looking for a postgraduate associate - someone who has recently finished university and is ultimately looking to apply to medical school or graduate school. It is a TWO YEAR clinical/translational position, where you will be interacting closely with patients, involved in translational clinical trials, and working hands on in the lab and with clinical databases. The ideal candidate is a great communicator, organized, and enthusiastic about patient-oriented clinical and lab research. You will get dedicated mentoring not just on the science and clinic, but also on career/professional development as well. We are looking for someone to start ASAP! More information here: postdocs.yale.edu/posts/2026… Please help to spread the word and RT! @DrChoueiri @VanAllenLab @tompowles1 @YaleCancer @YaleMed @SmilowCancer @kidneycan @OncoAlert @OncLive @KidneyCancer @A_P_S_A @cure_today @yalepathology @Yale_Urology @DrYukselUrun @MarkDSiegel1 @OncBrothers @DrKarineTawagi
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Had fun discussing AI innovations in health care with @TheAtlantic @tgoetz, highlighting work by @kenlkehl @ecerami @DFCIPopSci on AI for clinical trial matching in oncology + other exciting applications of AI across @DanaFarber theatlantic.com/sponsored/li…
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Link to the panel: piped.video/watch?v=rPV9r0xj… Link to Ken et al's MatchMiner-AI tool: arxiv.org/abs/2412.17228 We are always looking for ways to thoughtfully support of these efforts, reach out for more!
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