ALT Graphic on a cream background with thin teal and cream stripes along the right edge. Bold black text at the top reads \"17 catastrophic threats. One shared framework for action.\" Below, a grid of 17 teal square icons, each with a white pictogram and label, lists the threats: Air Pollution, Antimicrobial Resistance, Childhood Malnutrition, Climate Change, Collapse of Development Assistance for Health, Conventional Conflict, High Alcohol Use, High Blood Pressure, Income Inequality, Low Educational Attainment, Malicious Use of AI, Nuclear Conflict & Famine, Obesity, Pandemics, Poor Mental Health, Smoking, and Unhealthy Ageing. In the bottom left corner, \"THE LANCET\" wordmark appears alongside the circular green-and-teal IHME logo and the word \"IHME.\"

ALT Graphic divided into a dark-to-light blue gradient panel on the left and a cream-colored panel on the right, with thin teal and cream stripes along the right edge. On the left, white text reads \"Two threats to health carry extinction-level consequences, despite their low likelihood,\" with \"extinction-level\" in bold. On the right, two teal circular icons sit above supporting statistics: a radiation symbol icon above text reading \"133 million potential deaths could be prevented by reducing the risk of nuclear conflict by 2100,\" and a hand touching a screen icon above text reading \"10.4 billion years of health loss (DALYs) could be protected through action to reduce the risk of malicious AI,\" each with the numerical figures in bold. In the bottom left corner, \"THE LANCET\" wordmark appears alongside the circular green-and-teal IHME logo and the word \"IHME.\"

ALT Graphic on a cream background with thin teal and cream stripes along the right edge. Bold black text at the top reads \"Three recommendations for decision-makers.\" Below, three teal circular icons sit above three recommendations in black text, with the opening phrase of each bolded: a hospital building icon above \"Build threat-ready, equitable health systems that respond to a wide range of health threats, not just pandemics\"; a lightbulb icon above \"Back breakthrough innovation including new vaccines, antibiotics, obesity treatments and climate technologies\"; and a target/focus icon above \"Track threats so that evidence keeps pace with emerging and changing risks.\" In the bottom left corner, \"THE LANCET\" wordmark appears alongside the circular green-and-teal IHME logo and the word \"IHME.\"