We observed the "multi-enhancer hub" structure in our scMicro-C data, and I have discussed the formation mechanism of this hub. LDB1-mediated interaction is one of them and we plan to construct an LDB1-degron cell line. Pleased with the swift confirmation of this finding.
Congrats to @ngaboreden @blobelgroup with RCMC contribution from @ViraatGoel @hansen_lab .
Having recently worked on what we thought was a looping factor (ZNF143 biorxiv.org/content/10.1101/… ) it was amazing to work on a strong Enh-Promoter looping factor LDB1 biorxiv.org/content/10.1101/…
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