Postdoc in Feng Zhang lab @BroadInstitute. Graduated from Sunney Xie Lab at Peking University.
Boston
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Honggui Wu retweeted
🚨 Today in @Nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n]
nature.com/articles/s41586-0…
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Honggui Wu retweeted
🤔
“Here we present evidence that eukaryotic circular RNAs (circRNAs) can serve as templates for 3' to 5' backward translation (BT), yielding polypeptides with distinct sequence and structural features not found in canonical proteomes.”
biorxiv.org/content/10.64898…
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Honggui Wu retweeted
Whole-genome single-cell multimodal history tracing to reveal cell identity transition biorxiv.org/content/10.1101/… #biorxiv_genomic
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Spatial methylome + transcriptome.
Spatial joint profiling of DNA methylome and transcriptome in mammalian tissues biorxiv.org/content/10.1101/… #biorxiv_genomic
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Our scMicro-C paper is out in @NatureGenet! Huge thanks to the reviewers for their valuable insights, to @XieSunney for unwavering support, and to fantastic collaborators @JiankunZhang21 & @tanlongzhi. Thrilled to share this work!
Very excited to share our work on high-resolution single-cell Micro-C, which is on bioRxiv now. Here we reveal that cohesin-mediated loop extrusion participates in transcription with kilobase-resolution single-cell 3D structures. biorxiv.org/content/10.1101/…
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Honggui Wu retweeted
Ironman. Maternal iron deficiency causes male-to-female sex reversal in mouse embryos nature.com/articles/s41586-0…
@Nature
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Honggui Wu retweeted
In @nature we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR-Cas9 enzymes, offering safer & more genome editing tools. 🧬🖥️
@RachelSilvers11 @CGM_MGH @MGH_RI @MassGeneralNews @harvardmed
nature.com/articles/s41586-0…
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Honggui Wu retweeted
🔥🔥🔥OUR NEW PREPRINT: Slowing and reversing aging? Nature does it, here we show how! Age deceleration and reversal gene patterns in dauer diapause. Huge congrats to Kristy Totska, João Barata, Walter Sandt and @Meyer_DH biorxiv.org/content/10.1101/…
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Honggui Wu retweeted
Introducing RAEFISH, our lab's new flagship image-based spatial transcriptomics technology that simultaneously enables single-molecule spatial resolution and whole-genome level coverage of long and short, endogenous and engineered RNA species in cell cultures and intact tissues.
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Honggui Wu retweeted
We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their DNA targets. science.org/doi/10.1126/scie…
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Honggui Wu retweeted
Sequencing by Expansion (SBX) -- a novel, high-throughput single-molecule sequencing technology biorxiv.org/content/10.1101/… #biorxiv_genomic
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Honggui Wu retweeted
Did you know cancer cells can be electrically active, just like neurons? This electrical activity plays a key role in tumor progression. Excited to share my first postdoc paper at @TheCrick (and first paper from @LiGroup_Crick), published in @Nature!
nature.com/articles/s41586-0…
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Honggui Wu retweeted
New #preprint from our lab at @IMBA_Vienna !
How do DNA breaks locate homology sites in the vast space of the human genome? We show how #cohesin guides homology search for faithful repair!
Read more 👉 tinyurl.com/DSBcohesin
Follow along for key insights! 🧵1/12
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Honggui Wu retweeted
.@LanJiangBoston and colleagues developed droplet-based UDA-seq by incorporating a post-indexing step into two-round combinatorial indexing, enhancing throughput for large-scale single-cell analysis.
nature.com/articles/s41592-0…
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Thrilled to introduce a new single-cell 3D genome analysis tool to our toolkit! Our high-throughput droplet Hi-C (dscHi-C) and dscHi-C-multiome methods use droplet microfluidics to generate tens of thousands of single-cell Hi-C profiles with high sensitivity in a single batch.
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dscHi-C allows us to investigate chromatin reorganization during mouse brain aging, while dscHi-C-Multiome reveals the complex relationship between genome structure and gene regulation. Learn more here:
nature.com/articles/s41421-0…
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It has been a wonderful collaboration with @MaoxuC, and I deeply appreciate @XieSunney 's support and guidance throughout the project.
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Honggui Wu retweeted
WHY DOES THE EPIGENETIC CLOCK TICK?
While money has been poured into developing therapies to reverse the epigenetic clock (@altos_labs 🤑), why the epigenome changes with age at all is unclear.
In @NatureAging today, we suggest a potential driver: somatic mutations.
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Congratulations!
After my first public report at the Double Helix 70’s celebration (bit.ly/4iONi3M) on Oct 2023 and a bioRxiv on June 2024, FOOtprinting by dsDNA DeamInasE (FOODIE), the major effort of my CPL/PKU group, delayed by the pandemic, has been yearmarked by today issue of PNAS (bit.ly/3BDpP4P). Congratulations to all team members, and looking forward to using this tool to decode the functional human genome with the community.
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Honggui Wu retweeted
A foundation model for enzyme retrieval and function prediction is released.
EnzymeCAGE is trained on ~1M enzyme-reaction pairs via CLIP, and can be used to annotate unseen enzymes or orphan reactions.
We open-source it before releasing the manuscript: github.com/GENTEL-lab/Enzyme…
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