@TriIMDPhD @junyue_cao lab @RockefellerUniv @WeillCornell (views are my own) Previously @broadinstitute @RutgersU-B.A
New York, NY
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Spatial genomics has existed for many years, but it has often been limited by complex imaging systems, specialized equipment, and $$$.
With IRISeq, we wanted to simplify this to a simple PCR rxn. nature.com/articles/s41593-0…
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AbdulAbdul retweeted
So excited to see my thesis work out in the world! Incredibly grateful to my co-first author Chhiring, @AnnaEnim, and the many people who contributed to this work and made it possible. So much went into this one 🎉
How does interferon-alpha interfere with clonal evolution in human blood stem cells? We address it here @natureGenet: nature.com/articles/s41588-0…
🎉 Congrats to our super talented students Chhiring Lama, @danielle_isakov! Wonderful collab w/ Ron Hoffman. @WCMC, @WCMCPathology
🧵⤵
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By deciphering the molecular signatures of millions of mouse cells, Rockefeller's @junyue_cao has found that aging is not haphazard wear and tear but rather a “remodeling of the cell society.”
Learn more in this piece from @QuantaMagazine: bit.ly/4in9iVu
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Our paper is officially out in @NatureComms today rdcu.be/fvoEY Congrats to @xu_zxu and Aileen from the lab!
New preprint alert! 🚀 Across 60 human cancer cell lines spanning 20 cancer types, single-cell RNA+ATAC reveals pan-cancer cell-state heterogeneity, core gene-regulatory networks, and an EMT axis conserved across tissue origins.
Huge congrats to first author @xu_zxu, who recently defended his PhD, and Aileen Ugurbil from our lab @RockefellerUniv! biorxiv.org/cgi/content/shor…
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We are heartbroken to have lost our founder, who provided so much inspiration, but we are all honored to carry on the science he loved so much. picower.mit.edu/news/picower… #neuroscience #biology
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I couldn’t be prouder to announce that @tanmana_mitra’s thesis work identifying how metabolic demand drives terminal T cell exhaustion is out today in @ImmunityCP : authors.elsevier.com/a/1nQx9…
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Wow such cool work: A human developmental and adult brain atlas benchmarks dopaminergic stem cell models and cell therapy candidates
biorxiv.org/content/10.64898…
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Congrats @JasonSynaptic and team! Stunning and easy to understand results, which is becoming more rare these days in neuroscience.
Very excited for our new paper, now out in @CellCellPress! /🧵The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms of Tau transmission are not clear. /1
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We’re happy to announce 2 releases today:
- 🧠Brain2qwerty v1 is published at @NatureNeuro
- 🚀 Brain2Qwerty v2 is now publicly released
Explore how we decode sentences from non-invasive brain recordings: facebookresearch.github.io/b…
Links:
📄v1 Nature Neuro: nature.com/articles/s41593-0…
📑v2 Meta preprint: facebookresearch.github.io/b…
💻Code: github.com/facebookresearch/…
📊Data: huggingface.co/datasets/bcbl…
📝Blog: ai.meta.com/blog/brain2qwert…
🧵Thread: nitter.net/JarodLevy/status/20715…
🧠⌨️ Decode language from brain activity without surgery. 🧠⌨️
Brain2Qwerty V1 is officially published in Nature Neuroscience. Today, we're releasing Brain2Qwerty V2.
We achieve unprecedented performance for a non-invasive MEG setup.
Details below 🧵👇
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Our CytoSignal paper is now published in @NatureGenet! During revision, we generated a one-of-a-kind dataset with direct measurements of ligand-receptor protein interactions in situ in the mouse embryo, along with Visium HD spatial transcriptomics. nature.com/articles/s41588-0…
How can you use RNA velocity to infer the dynamics of cell signaling from spatial transcriptomic data? Check out our new preprint!
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I’m delighted to finally share work from my PhD with @dalygene and @s_mccarroll.
We show how human genetics and AlphaFold3-predicted protein structure can be combined to discover new mechanisms underlying missense risk in brain disorders.
1/n
biorxiv.org/content/10.1101/…
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Delighted to share our new preprint on xVDM (cross-linked volumetric DNA microscopy), turning the protein scaffolds inside intact tissue into dense, DNA-encoded proximity networks for transcriptome and protein mapping.
biorxiv.org/content/10.64898…
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Exciting breakthrough technology from the lab, now live in @CellCellPress ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
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Congrats @xu_zxu and Aileen on this amazing work!
Thank you so much Jun! This was a great team effort with the brilliant but Twitterless Aileen, an MD-PhD student in the @junyue_cao Lab. It has been such a privilege to work with everyone in the lab and to call @RockefellerUniv my PhD home.
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New preprint alert! 🚀 Across 60 human cancer cell lines spanning 20 cancer types, single-cell RNA+ATAC reveals pan-cancer cell-state heterogeneity, core gene-regulatory networks, and an EMT axis conserved across tissue origins.
Huge congrats to first author @xu_zxu, who recently defended his PhD, and Aileen Ugurbil from our lab @RockefellerUniv! biorxiv.org/cgi/content/shor…
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New preprint alert🚀 Using TrackerSci, we quantified the birth rate of each cell type across the whole organism, and how these rates are rewired with age.
Huge congrats to the incredible Dr. Lu @ziyu__lu from @RockefellerUniv, who just defended today!
biorxiv.org/content/10.64898…
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Today at #ASCO26, more results about the newest clinical trial of daraxonrasib: In the Phase III RASolute-302 trial, a once-daily RAS(ON) inhibitor nearly doubled median overall survival (13.2 vs 6.7 months) and reduced the risk of death by ~60% versus chemotherapy in previously treated metastatic pancreatic cancer.
KRAS was once considered “undruggable.” This is what persistence in science looks like.
A landmark moment for targeted therapy and for patients who desperately need better options. #CancerResearch #PancreaticCancer
Pancreatic cancer has one of the most suppressive tumor microenvironments in oncology.
But two pancreatic cancer results dropped today. Both matter.
1. BioNTech mRNA neoantigen vaccine: nearly all responders still alive at 6 years. 98% of induced T cells were de novo — the immune system learned to see a cancer it had always been blind to.
2. Daraxonrasib: 47% ORR, 92% disease control as first-line monotherapy. KRAS G12D, undruggable for 40 years, finally has a drug.
Different mechanisms. Same disease. Both working.
<13% of patients survive 5 years. That number is about to change.
great day for science! 🔥
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There hasn't previously been a treatment vs pancreatic cancer this successful. Striking improved (a > doubling) survival results @NEJM and @ASCO today with daraxonrasib, which also became available via an FDA approved early access program and began shipping to physicians this week @RevMedicines
nejm.org/doi/full/10.1056/NE…
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Cardiac "remuscularization" for treating severe heart failure with patched heart muscle derived from stem cells (a biological ventricular assist device) successful in 12 of 20 patients @NEJM
nejm.org/doi/full/10.1056/NE… nejm.org/doi/full/10.1056/NE…
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lymphocyteが脳老化に於る炎症と脳室恒常性を制御
IRISeqは光学撮像不要のビーズ間配列決定で脳組織を空間的にprofiling
老齢mouse脳で脳室IFN炎症をlymphocyteが駆動しlymphocyte欠損が上衣細胞を保護する新機序を解明
OA
#aging
#immunology
#papers
nature.com/articles/s41593-0…
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