This work involved extensive simulations with and without perturbations and model modifications (21 conditions). The code, models, and all simulation results are freely shared, so anyone can build on our results.
🧵 8/
Many thanks to all the co-authors: Shinya Ito (@shixnya), Darrell Haufler, Kael Dai, Ahmed Abdaltawab, Yiti Li, Eli Z. Sennesh, Diego Mendoza-Halliday, Andre M. Bastos (@BastosLabNeuro), and especially @AntonSArkhipov.
🧵 9/9
Day 2 of the @AllenInstitute Modeling Software workshop, with presentations by Laura Green and
@shixnya.
- Your models need inputs-and how to stimulate them.
- And, all about differentiable bio-realistic models of brain circuits (we can train them via backpropagation!).
First day of the @AllenInstitute Modeling Software workshop - welcome to all the participants.
@beaherrera kicks us off with introduction to our Brain Modeling ToolKit (BMTK), SONATA data format, and VND. Darrell Haufler follows up with tutorials about biophysical modeling.
ANNs can match neural activity.
But without biological constraints, they achieve it via the wrong mechanisms.
In our new V1 model, biologically constrained training achieves both.
Full story from our team leader, @AntonSArkhipov.
bioRxiv link: doi.org/10.64898/2026.03.13.…
A reminder that we will have a nice and fun Modeling Software Workshop @AllenInstitute on July 20–22.
It's free. We offer some travel support. And you get to learn about BMTK, SONATA, and VND.
Apply by March 15!
alleninstitute.org/events/20…
Presenting today at SC’25: a full microscopic-level simulation of the entire mouse cortex on the Fugaku supercomputer.
Big day for the collaboration between our @AllenInstitute group and the lab of Prof. Tadashi Yamazaki.
See here: sc25.conference-program.com/…
1/8
Check out our #Sfn2025 posters this afternoon: @shixnya and @beaherrera present simulations of cortical neurons and circuits and Paul Olsen talks about linking in vivo ophys with spatial transcriptions.
What happens when you combine 10 years of brain data with one of the world’s fastest supercomputers?
A virtual mouse cortex simulation, thanks to a global collaboration.
Discover how it was made and how it could help researchers study brain diseases: alleninstitute.org/news/one-…
Cool updates in our newsletter:
📺 3D neuronal visualization in VND linked to Python notebooks via zmq
🧠 Stabilized Supralinear Networks implemented in BMTK
📢 Upcoming presentations at CNS*2025 and JNS by @beaherrera and @shixnya
See more and subscribe:
t.e2ma.net/message/3njjhi/jw…