Cell Biology of Early Development, Genome Activation, Membraneless Organelles and Synthetic Biology, from the Good Lab @ Penn. @buenoscience@mstdn.science
Philadelphia, PA
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Lunch with the group today to celebrate the past and upcoming New Year and submission of 3 papers. Go team! @themaxwadley @WenchaoQian @MVGarabedian
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Followup. Great end to our first day at #CellBio2024 in San Diego: delicious dinner with our speakers! Cheers to new friends
Very excited to co-host an ASCB subgroup tomorrow on ‘Biological Size Control and Scaling’ with Hui Chen and Jan Skotheim. @hui_chen2 @janskotheim. #CellBio24. Sat Dec 14, from 9:30-11am in Rm 29C. Come with questions and hear about the amazing work from our presenters! @jonasbcremer @MaggieXzj @UmaleSaransh @sandhya_manohar
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Very excited to co-host an ASCB subgroup tomorrow on ‘Biological Size Control and Scaling’ with Hui Chen and Jan Skotheim. @hui_chen2 @janskotheim. #CellBio24. Sat Dec 14, from 9:30-11am in Rm 29C. Come with questions and hear about the amazing work from our presenters! @jonasbcremer @MaggieXzj @UmaleSaransh @sandhya_manohar
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Super energized after an awesome student invited seminar visit to UTSW Biophysics hosted by Matt Amato from @JWoodruffLab. Student led JC, lunch, coffee hour and dinner. Inspiring stuff! And nice to see colleagues and friends @HenneLab @bsabari @biophysics_utsw
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Our first lab wedding! With Good lab alumni back in town. A magical experience. Congrats to Wentao and Wenjia. @MVGarabedian @themaxwadley @WenchaoQian @hui_chen2 @rmwelles
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And we’re off! Global Summit on Synthetic Cells at SIAT. With global leaders from US, Europe and Asia together in fabulous Shenzhen. I am amped! @KateAdamala @cees_dekker @SchwilleLab #SynCell
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Invigorating seminar visit to U. Michigan MCDB @UMich_MCDB @UMengineering hosted by friends Ann Miller and Allen Liu. A beautiful time to be in Ann Arbor!
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Fantastic talk from my former advisor @rebeccaheald at XRET meeting. Mind blowing results on brain tissue organization in polyploids
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Bucket list checked. Hosted Magdalena @ZernickaGoetz for a fabulous seminar on embryo self organization and development. Inspiring work for the RG Williams lecture @PennMedicine
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Super fun outing with the lab today against backdrop of beautiful Philly skyline
@MVGarabedian @WenchaoQian @themaxwadley
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Gripping, elevated science and hiking in Les Diablerets for ‘24 IDP GRC. @GrcIdp . Thanks Tanja @TanjaMittag & Birthe @BBKrage for organizing
Learned a ton. Saw beautiful Switzerland, west to east
Great glacier hike with new friends Pilong Li, Yi Lin, Danfeng Cai @DanfengCai
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Inspiring Juneteenth lecture at Penn by Freeman Hrabowski III. Important words about purpose and inclusion in science. @CAMBUpenn @PennCDB
Nice intro by Penn’s own HHMI Hrabowski scholar @MustafaMir16
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Awesome talk from PhD Student @WenchaoQian at the 2024 CDB Retreat. Great job rep’ing the lab! @PennCDB
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To make sense of the mutants we turned to @JeetainMittal, whose computational simulations helped reveal that the balance of homotypic and heterotypic interactions determine whether two IDPs will co-partition
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Although FUS LC leverages Tyr and Arg to interact, similar to rules for LAF-1 RGG, adding Tyr to FUS LC did not promote co-partitioning but instead appeared to strengthen its homotypic interactions and ability to condense
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We started the project interested in whether pairs of intrinsically disordered proteins (IDPs) could form discrete condensed phases in vitro and in cells. We found that the LAF-1 RGG domain and FUS low complexity (LC) domain formed spatially distinct compartments
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Thrilled to finally announce our work on the selectivity of disordered protein condensation in @NatureChemistry. Great collaboration with @JeetainMittal Led by @rmwelles and @kandarp_sojitra. rdcu.be/dxP4r. See related work by Brangwynne lab rdcu.be/dzddw
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Another great holiday party with the Good lab and Ramage labs. These scientists can cook! @ramagelab @MelissaMolho @MVGarabedian @WenchaoQian
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Very excited to co-host a subgroup today at ASCB mtg on ‘Biological Size Control and Scaling’ with Hui Chen, Jan Skotheim. Mon Dec 4, from 3:30-6p in Rm 205b. Come hear about the amazing work from our presenters! #CellBio23. @hui_chen2 @JanSkotheim @GaronaAna @MarcoFumasoni
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And already had a great first talk in morning session from former postdoc Hui Chen, who is a now a new PI @hui_chen2.
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The Good lab is excited to be at ASCB-EMBO CellBio23 meeting in Boston! Come check out our research and say hi. Attending: @MVGarabedian, @WenchaoQian, @hui_chen2
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Incredible lab art collabo from Holly Ramage Lab at Thomas Jefferson U., Dept of Micro and Immuno. @ramagelab @TJU_Micro @JeffersonUniv . Piece Titled "Calabaza de los muertos"
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Really fun seminar visit at @Pitt_Chemistry. An ecclectic day of chemical biology and model organisms and a awesome dinner with friends Alex Deiters, Lance Davidson and Seth Childers. @ChildersLab @mechmorpho. And great to see @lab_zhang at CMU
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Thrilled that my colleague Ben Stanger @BenStanger01 wrote a book #fromonecell. wonderful book signing at Penn with friends. Congrats on a great read!
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Hanging out with physics legends at qBio2023 in Shenzhen China. Fantastic meeting. #qbio2023. Making new friends at SIAT, iSynBio
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Fashionable goodbye to a wonderful lab manager Rachel @rmwelles who will be dearly missed. She is going to do great things as a PhD student at @CAMBUpenn
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Next time you are in Pasadena visit Mission Liquors. They have 2-3 aisles of mescals. I like most bottlings from Pierde Almas. Try a Tobala from Del Maguey or another producer
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An awesome meeting capped by a visit from Goldy to hand out poster prizes to the stunned trainees. #SynCell2023
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My lab enjoyed JC paper from @NVastenhouw on how Nanog condensates organize transcriptional bodies at miR-430 loci in early development. doi.org/10.1016/j.cub.2022.1…. Published a few months ago and worth a read! Thx @WenchaoQian for presenting.
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Packed house for Biological Size Control and Scaling at #ASCB2022. Capped by a memorable speaker dinner. Amazing talks from @JeanVolland @johan_elf_ @SimoneReber @martingraefe @JanSkotheim @BastoRenata @hui_chen2 @arich9109
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Another great talk from Good lab PhD student @WenchaoQian on embryo size and ZGA gradients. And a visit from @LendertGelens who built the OG embryo temperature controller!
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Great first talk today for Good lab from @MVGarabedian. Sequence determinants for assembly of DNA damage condensates. Collab with @RogerRogergr
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My lab is amped for #ASCB2022 in Washington DC. We have talks from @MVGarabedian Sat 9:45 am (Rm 207B), @WenchaoQian Sun 3:45 pm (Rm 207B). And posters throughout. Looking forward to discussion!
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Excited about the ASCB-EMBO meeting in a few days! Check out our subgroup 'Biological Size Control and Scaling' on Mon Dec 5th that I am co-chairing with @JanSkotheim. Talks from @JeanVolland @johan_elf_ @SimoneReber @Nishit24 @BastoRenata @arich9109 and others. #ASCB2022
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Had a blast celebrating with former and current Good Lab members and collaborators, including @TheHammerLab . Very grateful to work with an awesome group of young scientists and to have such creative and supportive colleagues!
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Part 4. We synthesize the findings into a waddington landscape relating spatial position, division rate, and cell size threshold for ZGA, controlling the dynamics of genome activation in the blastula and early cell fating. Shows why Xenopus is so useful for this study!
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Amazing workshop @lorentzcenter in the Netherlands on how to reconstitute life and build synthetic cells. Walking the beach with intellectual giants!
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Amazing Xenopus cake and lab party. Anyone know whether blueberries can be used for IVF? HT to @hui_chen2 @WenchaoQian @Microscopy_Man
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Fun friday! The lab treated me to cake and personalized swag. High thanks to @hui_chen2 and rest of the group.
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We had too many things to celebrate - passing quals, papers, new lab members, etc - we had to get together with our buds @ramagelab. Thanks @DockStreetBeer
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Thrilled to be part of 2-day meeting at NIH on synthetic biology. Thanks to David Rampulla (@NIBIBgov) for organizing
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Paola's PNAS paper is now online. Great collaboration with Percec lab (Penn) to load hydrophobic drugs, protein and DNA aptamer cargo onto versatile and rugged vesicles.
pnas.org/content/early/2019/…
Penn News feature: penntoday.upenn.edu/news/art…
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Hui's paper on spatial patterning of zygotic genome activation was published as cover story in Developmental Cell (cell.com/developmental-cell/…). Also highlighted in Penn News (pennmedicine.org/news/news-r…).
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