Dan Okin retweeted
A new PAMP, a new innate immunity principle and a new preclinical application. I am so pleased to share our study on STING activation mechanisms in health and disease. Led by the fantastic Stephanie Ragland, follow the summary below for all we learned. cell.com/immunity/fulltext/S…
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Dan Okin retweeted
We are thrilled to announce an opening for a tenure-track assistant professor in PCMM, Boston Children's Hospital and Harvard Immunology! Apply by August 2, 2026.
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Dan Okin retweeted
Who wants to discuss innate immunity and host defense? Join us in Banff to share your exciting research. keystonesymposia.org/confere…
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Dan Okin retweeted
Application now open: Career Awards for Medical Scientists (CAMS) is a highly competitive program that provides $700,000 awards over 5 years for physician-scientists, who are committed to an academic career Deadline: 10/07/25 buff.ly/VdljzxQ #bwfcams
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Check out this must read from @Lo_Zanzi and @dfrboehmer on IFNs👇🏻
#InterferonPower! Thrilled for our latest work @CellCellPress! With @dfrboehmer, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free link 👉 authors.elsevier.com/a/1leKG…
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👇🏻👇🏻👇🏻Check out this great study on oxidized lipids and how they control inflammation!! Congrats @Lo_Zanzi !
#EpigeneticPower! Our #NewPaper @ImmunityCP shows that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2, blocking #IL10! authors.elsevier.com/a/1lS0g…
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Congrats @XuZhouLab on a fantastic study, excited to see where you take this next!
Beyond excited to share our #NewPaper in @CellCellPress! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH authors.elsevier.com/sd/arti…
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BRD4 acts as a pH sensor to tune inflammation bit.ly/3IOIyNU
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Dan Okin retweeted
Finally, our study on caspase-11 and its CARD-recognized molecular pattern is out in Science Advances! A small step, but we hope it opens new directions for studying caspase-11 and its ligands. 🔬🚀 #Immunology #Caspase11 #ScienceAdvances 🔗 science.org/doi/10.1126/scia…
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Congrats on the great story @JelenaLab!!
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.@FabiAlexFischer science.org/doi/10.1126/scia…
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Dan Okin retweeted
We have to stand up for science! Anyone who can join these rallies and believes that US science must be protected should come!
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The more I think about it, the more I think 2013-era morality is pretty much correct: * free speech good * starting companies and making good products good * monopolies bad, vendor lock-in bad * democracy good * greed bad * trying to achieve national security through oppressing people bad * cosmopolitan humanitarian values, caring about faraway people, etc good Things we've "learned" since then have been harmful more than helpful
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Dan Okin retweeted
I need people to understand how difficult it is to get an NIH grant. You spend months writing a proposal, following strict guidelines that include a detailed multiyear budget, bios of everyone on your team, plans for participant safety & ethical conduct. Then you send it off -1/n
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In a study published in @SciImmunology, led by @Dr_KatieM, @DanaFarber researchers have identified key factors that contribute to the success of donor lymphocyte infusion to treat relapse of acute myeloid leukemia after stem cell transplant. Read more: bit.ly/4hurQQg
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Wonderful piece @vcunningham and congrats on the new kid! Merry Christmas! 🎄
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1/ Introducing SCimilarity, a new foundation model to explore scRNAseq data across tissues and diseases! It learns a common measure of cell similarity by training a deep metric learning model on millions of cells from various human tissues and conditions. nature.com/articles/s41586-0…
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The recorded video of Dr. Jon Kagan seminar entitled Regulation of Innate Immunity is now available at “Global Immunotalks” YouTube Channel piped.video/nrgrK0SMqDU Hope you enjoy it! #globalimmuno #immunology
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Dan Okin retweeted
#EveryCellIsAnImmuneCell!💥Thrilled💥for our new paper @CellCellPress with @achillebro! We show that, during #IBD, type III #interferons delay gut repair by inducing #pyroptosis in intestinal epithelial cells via #gasdermin C upon ZBP1 activation! 1/n authors.elsevier.com/a/1k2OA…
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Thrilled to share our findings on NINJ1 autoinhibition, now online in @Nature. Big thanks to the amazing team @dixitvishva @Melissa_Truong @DrMCJohnson @AlexisRohou and many others. Video by the talented, twitterless Sergei Pourmal (1/3)
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