Protocols for inflammaging, longevity, long covid, mecfs/post infection care-Physician, Engineer. Chief Med Officer @RenegadeRes. Book appt 100apples.com
Annapolis, MD/Chautauqua,NY
- Tweets 5,987
- Following 847
- Followers 3,609
- Likes 14,450
Pinned Tweet
Thread attached about how the “confused” immune system drives covid / long covid and some things that can be done now to help reverse it. #LongCovid #Treatment #Science
1/n - Easier way to see TLR4 impact from viruses (TLR4 generally reacts to LPS and causes inflammation in sepsis. Some viruses - 4 shown in this paper “turn o TLR4 too”. (The confusion talked about in immune response in Covid?) k
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John Haughton MD, MS 🌻 retweeted
Scientists found that the creatine supplement millions take for muscle gains is quietly raising brain energy levels and slowing early Alzheimer’s cognitive decline by 30%
thesciverse.org/scientists-f…
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Post infectious diseases:
đź””converging on overlapping mechanisms - neuroinflammation, autonomic and brainstem dysfunction, immune-driven pathways
(And the inflammation blocks micro-vessel flow too).
Bloodflow, Metabolism, Immune, Neuro diseases… Target the 4 areas for clinical improvement.
Something exciting is happening in POTS/ME/CFS/Long COVID research right now. Multiple labs and clinicians, working independently, are converging on overlapping mechanisms - neuroinflammation, autonomic and brainstem dysfunction, immune-driven pathways, approached from completely different angles: imaging, immune markers, clinical observation, structural findings.
That kind of convergence is usually a marker of a field reaching scientific maturity. Early-stage fields tend to be scattered and contradictory. A field converging from multiple independent directions toward the same underlying biology is a sign there's real signal to chase. This is what it looks like when a research area starts to click into focus after years of being dismissed or fragmented.
Patients have waited decades for this kind of momentum. Grateful to see so many people pushing in the same direction.
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John Haughton MD, MS 🌻 retweeted
Something exciting is happening in POTS/ME/CFS/Long COVID research right now. Multiple labs and clinicians, working independently, are converging on overlapping mechanisms - neuroinflammation, autonomic and brainstem dysfunction, immune-driven pathways, approached from completely different angles: imaging, immune markers, clinical observation, structural findings.
That kind of convergence is usually a marker of a field reaching scientific maturity. Early-stage fields tend to be scattered and contradictory. A field converging from multiple independent directions toward the same underlying biology is a sign there's real signal to chase. This is what it looks like when a research area starts to click into focus after years of being dismissed or fragmented.
Patients have waited decades for this kind of momentum. Grateful to see so many people pushing in the same direction.
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John Haughton MD, MS 🌻 retweeted
It’s often said that there’s no biomarker for ME/CFS, Long Covid, Post Vaccine Syndrome, PSSD, Lyme Disease, etc.
I strongly disagree. However, it helps to have the right data and tools to visualise it.
To help people explore the Born Free disease model and better understand the connections between the minerals deficiencies, metal toxicities and disease model processes, I've added 10 random example pairs of Oligoscan (corrected, skin minerals + toxic metals) + Theriome Aristotle Plus data (296 metabolites) to the Metabolic Pathway Overlay tool.
bornfree.life/learn/metaboli…
Some common patterns to observe across these patient profiles:
1) Elevated toxic metals, with mineral and electrolyte deficiencies, relating to pathway alterations.
2) A reduced total NADP/NADPH pool size and impaired conversion of NADP to NADPH (low NADPH), with broad effects. The reported exception (#4) is where aluminium is not elevated.
3) Constraints on glycolysis and glycogen synthesis, gluconeogenesis.
4) Altered pyruvate and/or lactate levels, ratio.
5) Constraints on the pentose phosphate pathway and downstream PRPP synthesis.
6) Impairments in purine and pyrimidine metabolism, Cell Danger Response.
7) Oxidative stress.
8) TCA cycle alterations and constraints.
9) Issues with NAD+ synthesis and redox.
10) Reduced carnitine synthesis and associated carnitine-shuttle constraints.
11) Elevated glutamate relative to low GABA, except where severe induced malnutrition constrains glutamate synthesis.
12) Issues with glutathione metabolism.
13) Issues involving magnesium and Mg-ATP.
14) Urea-cycle and nitric oxide synthase impairments, with potential effects on vascular tone.
15) Dysregulated neurotransmitter synthesis and degradation.
16) Impaired conversion of choline to betaine.
17) Impaired methylation and associated SAMe, glycine, and cysteine metabolism.
18) Impaired creatine synthesis.
Importantly, you can see coherence between the tests and inferred causality for pathway alterations.
When you consider these metabolic alterations in specific cells / tissues - brain, liver, kidneys, thyroid, immune, etc., it becomes much easier to understand how mitochondrial dysfunction creates systemic impacts and a progressive cascade.
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Metformin - Fasting in a pill. Pushes cells to recycle better. Pushes body toward “conserve/repair” mode.
Clinically helpful with additional approaches in long covid inflamed state too.
A new scientific review finds metformin, a decades-old diabetes drug, interacts with nearly every major biological process scientists link to aging
ow.ly/Lug350ZGz4q
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Let us challenge standpoints, assumptions or hypotheses. Let’s be critical about the real progress in that space over the years. But do not create (verbal) violence and threats. This is applicable for all people involved. Whether you are a patient, a researcher, an advocate or whatever you role is…!
Let’s stay calm and solve LongCovid.
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Differences exist. They will and they should when we dont know all the answers.
What David and others have dealt with over the past few days is unacceptable.
We are all in this together, patient, clinicians, researchers - including some cross over in the 3 groups.
🔔 improv says “yes, and”. It keeps the conversation/dialog moving forward
———
“no but”; “choose this or that” before the answers are known -
đź””weakens the field and slows progress - fighting inside rather than getting resources and information from outside.
Choose “yes and”.
@PutrinoLab
the last few days at a conference being quietly shadowed by 4 security guards because the Dutch police, independent of the conference, decided that there were credible threats of harm against me I can say that this hits home for me. I was also devastated to learn that similar
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🔔Full tissue healing needs “fixing” AND “remodeling”.
(Same with broken bones and with full thickness skin into tissue wounds.
We identify collagen XVIII as an important link between persistent ECM remodeling, altered stem-cell behavior, and chronic inflammation.
Our findings suggest that recovery may require repairing not only the cells—but also the environment they return to.
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Discussion on”severity”, steps and measurements in mecfs.
🔔Shows - the words “mild moderate and severe” are very CONTEXT SPECIFIC on measurements.
(If a study does not have bedbound/housebound measured, its lower number is higher than
#RenegadeResearch
#ME advocates, what's ur take on this paper stating Mild ME subjects took >8K, Moderate >5K & Severe just over 2K steps/day? If true I'm biased by hearing about extremely severe cases. I overdid it in June/July & I'm down 50%->2.2K/d avg = homebound/severe per paper. 1/3
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🔔Long Covid continues to affect some people’s ability to work.
That said,
đź””it is possible for many, not all, to go through steps of healing and functional gain to get back to some kind of satisfying productivity or work.
@RenegadeRes
For people with ME/CFS, 63% are unable to work because of their illness.
Among people with POTS, 72% have had to modify their jobs.
Long COVID cost the equivalent of 2.3 million full-time jobs in 2023 and $218 billion in lost earnings.
More than 400 million people worldwide live with Long COVID alone, which is more than the entire U.S. population of 343 million.
Let that sink in.
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Great way to get up to date info on mecfs and related conditions from those working on it
Ron Davis’ community symposium on mecfs
Register for the community symposium on Friday, Sept 11 starting at 8am PT. It's free.
stanford.zoom.us/webinar/reg…
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Tragedy to Recovery to Hope for many through generosity that will drive research and accelerated learning for clinical care.
A place to make people with brain injuries and issues better in NYC.
đź””family challenges and birth of new opportunity for improving care. What a story!
At midnight on February 6th, earlier this year, the doorbell to our apartment rang. The doorbell was followed by a pounding on the door. I answered the door and a security person in our building handed me his phone. It was my oldest daughter Eloise. She had found my 26-year-old daughter unconscious on the floor of her apartment and had called 911. The EMT team was already there, but they did not know what was wrong with Lucy or to which hospital they would take her.
I threw on some clothes and jumped in an Uber heading east toward Brooklyn. (Lucy lived alone in Williamsburg.) On the way, I learned that they were taking her to Elmhurst, a City trauma hospital in Queens. I arrived about five minutes after the ambulance to join Eloise, Lucy’s mom, and a friend, and waited to learn what was wrong.
After about 15 minutes, I asked a nurse where she was. I looked over his shoulder to his computer. Next to her name, it said “non-responsive.” I walked into the emergency room and wandered around looking for her until I found her unconscious on a gurney surrounded by several doctors and nurses.
By about 2:30am with the results from a CAT scan, Lucy’s doctors had determined that she had a massive brain hemorrhage and would need an emergency hemicraniectomy to release the pressure on her brain and remove the blood from the hemorrhage. I called our wonderful friend and family doctor Eddie Fisher and explained what was going on. He woke up Josh Bederson, Chairman of Neurosurgery at Mount Sinai, to find out more about Zach Hickman, the neurosurgeon on call that night. Dr. Bederson said Hickman was an excellent surgeon, which was comforting as we had no choice.
The surgery to save Lucy’s life began around 3:15am and finished around 5:30am. It was successful.
The following day, I joined Lucy in an ambulance while she was being transferred to Mount Sinai on Madison Avenue. Later that day, we determined from Lucy’s Oura ring that her hemorrhage had occurred around 9am, which meant that more than 19 hours had passed from the time of the hemorrhage to the completion of the surgery to release the pressure on her brain (I only wish @ouraring had an alert for this kind of a medical event. Imagine it could call a family member if the wearer doesn’t cancel the alert).
I later learned that the standard of care is not to do surgery to save a patient with a large brain bleed if more than five hours have passed since the hemorrhage. Even when the surgery is done, I was told that the likely outcome for the patient is a few months in a nursing home and death from pneumonia.
When I met Lucy’s doctors, I did my best to inspire them: “Let’s see what can be accomplished if we give her the best care possible and we invest unlimited resources to restore her to life.” And I promised that whatever we learned we would make available to everyone.
Dr. Chris Kellner, her neurosurgeon, and Dr. David Putrino, Director of Rehabilitation Innovation for the Mount Sinai Health System have led Lucy’s care team since that day. Words cannot describe the remarkable and compassionate care that she has received beginning with the EMT team and then from nurses, doctors, therapists, and the army of people who have worked to save her and return her to life. To this day, we have a daily Zoom where we discuss her progress and make adjustments to her care. While her care and oversight have been incredible, the learnings for the Mount Sinai team have also been elucidating and will assist in the care of many others.
Lucy began in a bad place. She was in a coma for several weeks and then awoke not being able to breathe on her own, unable to walk, see or speak.
Over the last six months, she has recovered her cognition – she understands everything including her circumstance – is able to walk a hundred or more steps at a time with assistance, is making progress with sounds, vowels and consonants and the beginnings of speech, but she remains unable to see.
Each day, she makes a little progress, and daily progress compounds. Every day I tell her that she just needs to make a little progress and it won’t be long before she is back.
We remain optimistic that Lucy will return to normal function. It will likely take years, but I believe it is only a matter of time, hard work, and technological progress, along with some, and perhaps a lot, of divine intervention.
Many people have been praying for Lucy and we are incredibly grateful for the prayers and remarkable support she has received. Lucy’s friends have been with her every day since the beginning, and their presence and friendship have saved her life and helped to rebuild and maintain her spirit. And on a very positive note, Lucy’s challenge has brought together our entire modern family who have all been incredibly devoted to her care and recovery.
Lucy's vision and other faculties may require some form of brain computer interface, work that is underway at Neuralink, Precision Neuroscience, Science, Synchron, Nudge, and other companies in the space.
If you are going to have a devastating brain injury, now is the best time in history for that to happen. We are living in a world when you can be confident that the blind will soon see again. We are going to do everything we can to help make that happen, including by assisting existing companies in the space.
With respect to our promise to make Lucy’s care available to others, we have made good progress. In May, a real estate colleague made me aware of a 93% vacant, brand new, 400,000 square foot Class A+ purpose-built biotech facility on West End Avenue between 65th and 66th Streets that missed the market and was available for sale. The Pershing Square Foundation acquired the building 60 days later.
We also put under contract an adjoining 130,000 square foot building at 320 West 66th Street that is currently being used by Saturday Night Live for studio space. The building has 35-foot ceilings with massive column-free spaces that can be converted into superb rehabilitation facilities. We will close on the SNL building in December.
We are also acquiring an adjoining vacant lot with additional air rights. With just the existing zoning rights, we can add a 150,000 square feet for a total of 680,000 square feet, a lab footprint larger than Rockefeller University, and that’s without including the potential for an upzoning that would allow for substantially more buildable area on the site’s 3.4 acres with spectacular views of the Hudson.
Our goal is to build the world’s greatest brain research, rehabilitation, recovery, human optimization, and longevity institute. We have named it The Ackman Oxman Institute or the AOI for lack of a better name, but also to reinforce the point that Neri and I and our family are all-in on the mission.
The AOI will be patient-centric. It will not be an academic research institute that produces lots of papers, a Nobel Prize winner or two, but little if any results for patients. We will be laser-focused on cures, treatments, devices, rehabilitation and exercise equipment, and targeted and basic research with a goal of massively accelerating the time from idea to innovation to production to helping a patient.
While the AOI will be a non-profit, it will have highly commercial instincts. The AOI will have its own venture funding and will work to develop innovations to create companies that we will seed, assist, and spinout to ensure technologies, treatments, techniques, and drugs get to patients as promptly as possible.
On one 3.4 acre campus in what is still the greatest city in the world, we will do neurosurgery, neuroscience, rehabilitation, nutrition, BCI and device development, human trials, hyperbaric oxygen treatments, and life extension programs, and we will mandate and incentivize collaboration among the teams with no silos, politics, bureaucracy, or any other constraint that is inconsistent with the mission.
Mount Sinai will be an important partner and deservedly so, but it won’t be our only hospital or medical school partner as we don’t believe any institution has a monopoly on the best ideas or the best talent. We don’t believe in exclusive relationships because that is not in the best interest of patients.
Five years ago, we considered launching a brain institute inspired by Neri’s mom who sadly died from Alzheimer’s. We couldn’t make the math work as the real estate was too expensive and we believed it would be too difficult to recruit the best talent from universities to our effort.
Since then, the real estate became available at a 70% discount, universities became a much less attractive place to work due to politics outweighing meritocracy, protests that disrupt learning, the curse of antisemitism, and a decline in funding. Fortunately, during the same time, I made sufficient personal economic progress to make the AOI possible.
The advance of AI in the last few years will also enable us to greatly accelerate our mission. AI still has a lot to learn about human intelligence and the brain, and the AOI should be at the forefront of the interplay between the brain and AI.
Today, I am making a public filing disclosing a gift from Neri and me of ~$400 million or 10,000,000 shares of Pershing Square Inc. (PS) to the AOI. It is very early days for Pershing Square so these shares are intended to anchor the long-term work of the AOI as the shares compound over time while generating what we expect will be a growing stream of quarterly dividends to fund the Institute.
We will also be announcing an additional gift of similar and potentially greater size which won’t be in the form of Pershing Square stock to provide the AOI with the short- and intermediate-term runway necessary to enable it to achieve its goal of becoming a self-sustaining institute, which reinvests all of its revenues, royalties, and the economic rewards of company formation to advance the fields of brain health and human longevity.
Neri and I have chosen to anchor the funding of the AOI to maintain vision alignment and limit the need for the organization to focus on fundraising. We expect the AOI to be the best-resourced brain, rehab, recovery, and longevity institute in the world.
We are grateful to have been able to form a board which includes Dean Kamen (our generation’s Thomas Edison), George Yancopoulus (CEO of Regeneron), James Rothman (Nobel Laureate), Bernardo Sabatini (neuroscientist), Chris Kellner (neurosurgeon), Olivia Flatto (CEO Pershing Square Foundation), Neri Oxman, and myself.
We have recently identified a CEO who we expect to announce by October along with other key hires, and are beginning searches for a Chief Scientific Officer, a Chief AI/Technology Officer, a Chief Operating Officer, a Chief Financial Officer, and other key leadership roles.
If you find what we are building compelling and want to be part of the leadership team that creates and builds the AOI from a standing start, please send an email to: search@aoiinst.org with a short note as to why you believe you can help. Please include your best three ideas for the AOI along with a summary of your background and your most important accomplishments.
We promise strict confidentiality to those expressing interest in working with us.
We have learned from Lucy that the brain can recover from even catastrophic injury. There is so much more work to be done as the mind is a terrible thing to waste.
For details from my Pershing Square SEC filing see:
sec.gov/Archives/edgar/data/…
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Decreased swelling in spinal cord in the cspine after treatment with B12 in those who had clinical deficits and had B12 receptor auto antibodies.
(ABCD = name of disease)
đź””high blood and low csf b12
@joshual_tm @RenegadeRes
Five patients received B12 supplementation with or without immunosuppression, and four out of five improved. These treatment effects remain anecdotal, but motivate the team to eventually run a controlled trial.
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John Haughton MD, MS 🌻 retweeted
At 10:06pm on Aug 3, I watched a robot do something I thought was years away.
We were working on few-gradient learning with GEN-1.5, wondering how far we were from landing physical prompting: show the robot a task once, and it just does it. We YOLOed it, and the robot imitated exactly what we demonstrated, with 0 fine-tuning. We gave more prompts for different tasks. More successful rollouts landed. I could not believe my eyes.
Looking back, this represents the culmination of a huge amount of work across the entire team, many failed experiments, and years of groundwork from the community. I just happened to be the one standing in front of the robot when it all clicked.
@andyzengineer once asked me: "If Generalist failed tomorrow, what would we want to have left behind that could benefit humanity?"
I believe we found one answer: an existence proof of physical prompting.
Introducing GEN-1.5, a one-shot learner.
It can learn new tasks in a few seconds. Show it what to do, and it generalizes.
This capability emerged from pretraining on physical data at scale, as a step towards our mission of building general intelligence for the physical world.
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John Haughton MD, MS 🌻 retweeted
At midnight on February 6th, earlier this year, the doorbell to our apartment rang. The doorbell was followed by a pounding on the door. I answered the door and a security person in our building handed me his phone. It was my oldest daughter Eloise. She had found my 26-year-old daughter unconscious on the floor of her apartment and had called 911. The EMT team was already there, but they did not know what was wrong with Lucy or to which hospital they would take her.
I threw on some clothes and jumped in an Uber heading east toward Brooklyn. (Lucy lived alone in Williamsburg.) On the way, I learned that they were taking her to Elmhurst, a City trauma hospital in Queens. I arrived about five minutes after the ambulance to join Eloise, Lucy’s mom, and a friend, and waited to learn what was wrong.
After about 15 minutes, I asked a nurse where she was. I looked over his shoulder to his computer. Next to her name, it said “non-responsive.” I walked into the emergency room and wandered around looking for her until I found her unconscious on a gurney surrounded by several doctors and nurses.
By about 2:30am with the results from a CAT scan, Lucy’s doctors had determined that she had a massive brain hemorrhage and would need an emergency hemicraniectomy to release the pressure on her brain and remove the blood from the hemorrhage. I called our wonderful friend and family doctor Eddie Fisher and explained what was going on. He woke up Josh Bederson, Chairman of Neurosurgery at Mount Sinai, to find out more about Zach Hickman, the neurosurgeon on call that night. Dr. Bederson said Hickman was an excellent surgeon, which was comforting as we had no choice.
The surgery to save Lucy’s life began around 3:15am and finished around 5:30am. It was successful.
The following day, I joined Lucy in an ambulance while she was being transferred to Mount Sinai on Madison Avenue. Later that day, we determined from Lucy’s Oura ring that her hemorrhage had occurred around 9am, which meant that more than 19 hours had passed from the time of the hemorrhage to the completion of the surgery to release the pressure on her brain (I only wish @ouraring had an alert for this kind of a medical event. Imagine it could call a family member if the wearer doesn’t cancel the alert).
I later learned that the standard of care is not to do surgery to save a patient with a large brain bleed if more than five hours have passed since the hemorrhage. Even when the surgery is done, I was told that the likely outcome for the patient is a few months in a nursing home and death from pneumonia.
When I met Lucy’s doctors, I did my best to inspire them: “Let’s see what can be accomplished if we give her the best care possible and we invest unlimited resources to restore her to life.” And I promised that whatever we learned we would make available to everyone.
Dr. Chris Kellner, her neurosurgeon, and Dr. David Putrino, Director of Rehabilitation Innovation for the Mount Sinai Health System have led Lucy’s care team since that day. Words cannot describe the remarkable and compassionate care that she has received beginning with the EMT team and then from nurses, doctors, therapists, and the army of people who have worked to save her and return her to life. To this day, we have a daily Zoom where we discuss her progress and make adjustments to her care. While her care and oversight have been incredible, the learnings for the Mount Sinai team have also been elucidating and will assist in the care of many others.
Lucy began in a bad place. She was in a coma for several weeks and then awoke not being able to breathe on her own, unable to walk, see or speak.
Over the last six months, she has recovered her cognition – she understands everything including her circumstance – is able to walk a hundred or more steps at a time with assistance, is making progress with sounds, vowels and consonants and the beginnings of speech, but she remains unable to see.
Each day, she makes a little progress, and daily progress compounds. Every day I tell her that she just needs to make a little progress and it won’t be long before she is back.
We remain optimistic that Lucy will return to normal function. It will likely take years, but I believe it is only a matter of time, hard work, and technological progress, along with some, and perhaps a lot, of divine intervention.
Many people have been praying for Lucy and we are incredibly grateful for the prayers and remarkable support she has received. Lucy’s friends have been with her every day since the beginning, and their presence and friendship have saved her life and helped to rebuild and maintain her spirit. And on a very positive note, Lucy’s challenge has brought together our entire modern family who have all been incredibly devoted to her care and recovery.
Lucy's vision and other faculties may require some form of brain computer interface, work that is underway at Neuralink, Precision Neuroscience, Science, Synchron, Nudge, and other companies in the space.
If you are going to have a devastating brain injury, now is the best time in history for that to happen. We are living in a world when you can be confident that the blind will soon see again. We are going to do everything we can to help make that happen, including by assisting existing companies in the space.
With respect to our promise to make Lucy’s care available to others, we have made good progress. In May, a real estate colleague made me aware of a 93% vacant, brand new, 400,000 square foot Class A+ purpose-built biotech facility on West End Avenue between 65th and 66th Streets that missed the market and was available for sale. The Pershing Square Foundation acquired the building 60 days later.
We also put under contract an adjoining 130,000 square foot building at 320 West 66th Street that is currently being used by Saturday Night Live for studio space. The building has 35-foot ceilings with massive column-free spaces that can be converted into superb rehabilitation facilities. We will close on the SNL building in December.
We are also acquiring an adjoining vacant lot with additional air rights. With just the existing zoning rights, we can add a 150,000 square feet for a total of 680,000 square feet, a lab footprint larger than Rockefeller University, and that’s without including the potential for an upzoning that would allow for substantially more buildable area on the site’s 3.4 acres with spectacular views of the Hudson.
Our goal is to build the world’s greatest brain research, rehabilitation, recovery, human optimization, and longevity institute. We have named it The Ackman Oxman Institute or the AOI for lack of a better name, but also to reinforce the point that Neri and I and our family are all-in on the mission.
The AOI will be patient-centric. It will not be an academic research institute that produces lots of papers, a Nobel Prize winner or two, but little if any results for patients. We will be laser-focused on cures, treatments, devices, rehabilitation and exercise equipment, and targeted and basic research with a goal of massively accelerating the time from idea to innovation to production to helping a patient.
While the AOI will be a non-profit, it will have highly commercial instincts. The AOI will have its own venture funding and will work to develop innovations to create companies that we will seed, assist, and spinout to ensure technologies, treatments, techniques, and drugs get to patients as promptly as possible.
On one 3.4 acre campus in what is still the greatest city in the world, we will do neurosurgery, neuroscience, rehabilitation, nutrition, BCI and device development, human trials, hyperbaric oxygen treatments, and life extension programs, and we will mandate and incentivize collaboration among the teams with no silos, politics, bureaucracy, or any other constraint that is inconsistent with the mission.
Mount Sinai will be an important partner and deservedly so, but it won’t be our only hospital or medical school partner as we don’t believe any institution has a monopoly on the best ideas or the best talent. We don’t believe in exclusive relationships because that is not in the best interest of patients.
Five years ago, we considered launching a brain institute inspired by Neri’s mom who sadly died from Alzheimer’s. We couldn’t make the math work as the real estate was too expensive and we believed it would be too difficult to recruit the best talent from universities to our effort.
Since then, the real estate became available at a 70% discount, universities became a much less attractive place to work due to politics outweighing meritocracy, protests that disrupt learning, the curse of antisemitism, and a decline in funding. Fortunately, during the same time, I made sufficient personal economic progress to make the AOI possible.
The advance of AI in the last few years will also enable us to greatly accelerate our mission. AI still has a lot to learn about human intelligence and the brain, and the AOI should be at the forefront of the interplay between the brain and AI.
Today, I am making a public filing disclosing a gift from Neri and me of ~$400 million or 10,000,000 shares of Pershing Square Inc. (PS) to the AOI. It is very early days for Pershing Square so these shares are intended to anchor the long-term work of the AOI as the shares compound over time while generating what we expect will be a growing stream of quarterly dividends to fund the Institute.
We will also be announcing an additional gift of similar and potentially greater size which won’t be in the form of Pershing Square stock to provide the AOI with the short- and intermediate-term runway necessary to enable it to achieve its goal of becoming a self-sustaining institute, which reinvests all of its revenues, royalties, and the economic rewards of company formation to advance the fields of brain health and human longevity.
Neri and I have chosen to anchor the funding of the AOI to maintain vision alignment and limit the need for the organization to focus on fundraising. We expect the AOI to be the best-resourced brain, rehab, recovery, and longevity institute in the world.
We are grateful to have been able to form a board which includes Dean Kamen (our generation’s Thomas Edison), George Yancopoulus (CEO of Regeneron), James Rothman (Nobel Laureate), Bernardo Sabatini (neuroscientist), Chris Kellner (neurosurgeon), Olivia Flatto (CEO Pershing Square Foundation), Neri Oxman, and myself.
We have recently identified a CEO who we expect to announce by October along with other key hires, and are beginning searches for a Chief Scientific Officer, a Chief AI/Technology Officer, a Chief Operating Officer, a Chief Financial Officer, and other key leadership roles.
If you find what we are building compelling and want to be part of the leadership team that creates and builds the AOI from a standing start, please send an email to: search@aoiinst.org with a short note as to why you believe you can help. Please include your best three ideas for the AOI along with a summary of your background and your most important accomplishments.
We promise strict confidentiality to those expressing interest in working with us.
We have learned from Lucy that the brain can recover from even catastrophic injury. There is so much more work to be done as the mind is a terrible thing to waste.
For details from my Pershing Square SEC filing see:
sec.gov/Archives/edgar/data/…
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Lots of thoughtful patient presentations and responses / discussion that followed with basic science and clinical researchers
If you have the time, link below for the recording is worth the listen
#longcovid #mecfs #lyme
Thank you to everyone who attended our August 14, 2026 webinar ""Patients to Researchers: Lived Experience"! Such great and informative discussions
If you couldn't make it, here's the recording on our YouTube channel: piped.video/watch?v=kxlUUgO4…
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More proof that metformin prevents long covid.
đź””take it when/if you first get covid to prevent long covid.
The 3rd study is those that carry the dx of LC in a medical record, so frequency is less (vs those with symptoms of long covid).
@PutrinoLab
And in that study, the data EMR data was collected a few years ago when the ICD code was newer
Metformin/ Long Covid
A large, randomized, placebo-controlled clinical trial has found that metformin—a widely available diabetes medication—reduced the risk of clinician-diagnosed long COVID by approximately 50% when initiated during an acute SARS-CoV-2 infection. The findings, published in Clinical Infectious Diseases, add critical weight to a growing body of evidence supporting metformin's role as a preventive strategy against postacute sequelae of COVID-19.1
Read more..
@doc4care
pharmacytimes.com/view/metfo…
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