We’re sooo happy!😌Your love & passion for Tomb Raider @Flying_Wild_Hog are truly the best thing that could have happened to the series💚Thank you so, so much.

There is a fake longevity news site full of made-up stories designed to look like it's an academic journal. At least some people in the field are falling for it. A medical doctor posted on LinkedIn that @NirBarzilaiMD had written an article about the positive interim analysis of TAME, which sounded wrong to me since AFAIK TAME isn't funded yet. So I explored the site. There's a bunch of fabricated stores including one on the @DogAgingProject TRIAD clinical trial. Many of the biggest names in the field are listed as co-authors on fabricated "articles". Be careful who you trust. The signal-to-noise problem in longevity is only getting worse. longevity.chia.health/news

As far as I know EA hasn’t really prioritized aging because it’s much harder to do a clear cost-benefit analysis. There are just too many uncertainties around feasibility, timelines, consequences... Animal exploitation is actively inflicted harm, which is often easier to quantify

I'm a cardiologist. Everyone is sharing this study as a skin story. They're burying the part that matters. Scientists took the aorta of a 75-year-old donor, applied a single engineered enzyme, and stripped away more than 70% of the molecular damage — bringing it down to the levels you'd see in a 30-year-old artery. Published five days ago in Nature Communications. Revel Pharmaceuticals, with Calico and the University of Colorado. Here's what they erased. Sugar reacts with proteins in your body the same way heat browns bread — slowly, over a lifetime. It leaves behind a residue called CML, the most abundant advanced glycation end product in aging tissue. It welds itself onto collagen and elastin in your skin, your eye lens, and your arterial walls. Two things follow. Your arteries stiffen. And CML latches onto a receptor called RAGE, which drives chronic inflammation — the exact fire I've been writing about for months as the engine of heart disease. Since the 1980s this damage was considered permanent. Your body has no enzyme to remove it. Every existing approach only slows new damage from forming. Nothing touched what was already there. So they built an enzyme that doesn't exist in nature. They screened 45,000 protein structures, then ran five rounds of directed evolution across more than 500 million variants until they had CMLase — a molecular lawnmower that oxidizes the CML off the protein and restores the original, healthy lysine underneath. Not patched. Reversed. Over 70% cleared from elderly arterial tissue. Over 55% from elderly skin — below the levels found in 31-year-old skin. 45-78% in lens proteins. The CEO said they expected 20% and were floored. Arterial stiffness drives systolic hypertension, heart failure, and stroke, and I have no drug that reverses it. I can slow the process. I cannot undo it. This paper says undoing it may be possible. The caveats are real and I won't skip them. This was done on donated tissue in a dish, not in a living person. No functional data yet — we don't know if that artery got measurably more elastic. Delivering a large enzyme deep into human tissue is a hard, unsolved problem. Clinical trials are years away. But something considered permanent for forty years just came off human tissue. We spent a century learning to slow aging. Someone finally figured out how to erase it. Thank you @theallinpod @friedberg @chamath @pesottas

For me it's a no-brainer: 1) Yes, I'm afraid of getting old and yes I'm afraid of dying. 2) I love life and people. Aging kills both. Quoted below is a ridiculous attempt to expose something which is already the most obvious thing ever. People don't want to end up wrinkled, fragile and dead. Yes, that causes psychological problems because it fucking SUCKS. Yes, not feeling good about getting old is normal. You have every right to be concerned. Telling people to shove these feelings up their arses and "find meaning in wrinkles" and recognizing "aging is part of life" can only lead to psychosis and breakdown. The healthiest thing to do, however, is not facelifts but actively facilitating change by pushing your governments to act vs aging. Recognize your fear and act to reduce it, instead of masking it.

Alright, since most everyone has forgotten and many are claiming I'm making shit up, let's review. *cracks knuckles* 1/? A producer from story kitchen in charge of integrating the live action series, anime, and games had this to say in a public QnA (I transcribed it):

Perspective: Much focus on death/lifespan/longevity in aging. On how long people want-to/should live. If death is good v bad. My focus is early adulthood not the end. On re-achieving prime-of-life biology, repeatedly. I'd like more focus on this early end of adult life as goal.

My latest Methusalem Podcast episode is out with Dr. Karl Pfleger. We discuss different approaches to slowing versus reversing aging, sub-pathologies that drive aging, and the rapidly evolving longevity investment landscape. Enjoy! youtube.com/watch?v=wbBuAo0o… open.spotify.com/episode/724…

In case there was any doubt, here they are saying YET AGAIN very clearly without any doubt that it is not a reboot, it is the same lara, it takes place after the events of survivor blah blah.

Reverse aging isn't only about staying healthy. It's keeping your optimism, passion, energy, strength and youth. It's your parents staying healthy, it's staying up late and eating what you want. It's exercising at your peak and being excited about another trip around the sun.

This is what we've all been waiting for - it's time for a brand-new Tomb Raider: Legacy of Atlantis trailer! ❤️ Together with @CrystalDynamics and @amazongames, we're excited to share another look at the legendary adventure we're crafting. Adventure Beyond Legend

thank you, @EleanorSheekey for your questions and @agingdoc1 for spreading the link. Here lifespan.io/news/playing-the… and here biorxiv.org/content/10.1101/… are the popular and academic versions of the narrative discussed on the podcast. Friends, help please, as usual, spread the story with your likes and reposts. It's a lot better having a bad theory than none at all - let's get to the core of this.

Today we rallied outside the Swedish Parliament for life extension — and it was incredible! Thank you to everyone who showed up and made history with us. The movement is real 🙏 Watch the global livestream → youtube.com/live/4CHvbryuUb4 #FundLongevity

Right now in Stockholm.

Anyone heading to the fundlongevity.org/ rallies tomorrow? I’ll be outside parliament in Berlin calling for more funding for science. There are protests in 18 other cities across the world so check out the site for your local one! Can’t make it? Then you might want to…

Our voices start getting louder on April 8

1/My grandmother died this week. She was 97.5. She died the way many people "dream of" — nearly 100, in her sleep, surrounded by family. My mom was holding her hand. The sleep came on the second day after a stroke, but sure — a "good death."

1/ On April 8, 2026, we will rally to fight aging. A multi-city movement to bring life extension into the mainstream. If you believe aging should be solved, this is your moment. Join in person or watch live

Owe Zerge (1894-1983 Swedish Surrealist painter) "Victoria mortis"