repost... EDITORIAL should we basically put them on farms to live in the housing set up for migrants? I DO PUBLIC HEALTH NURSING SINCE 1991. we need to address the horror of winter coming & homeless people NOW.

piped.video/watch?v=blYFuXYg… SORRY TO PREACH

it has to be with a drone. its huge. the air the air is everywhere until its filled w/rocket fuel. WE ALL OWN THE AIR, @ELONmusk piped.video/uGI8A6g-wrI?si=0HA0…

Just 10 days of bed rest reduces mitochondrial content by double digits in older adults while ROS production spikes. Function stays intact only because each mitochondrion works overtime. A Journal of Physiology study tracked what happens to muscle mitochondria in 10 older men (average age 68) during 10 days of complete bed rest. This simulates what happens during hospitalization, illness recovery, or any period where you stop moving. The findings show a temporary compensation that masks underlying damage. Key findings: • Mitochondrial quantity dropped significantly • Damaging free radical production increased 62-65% • Energy production capacity remained normal • Each remaining mitochondrion worked harder to compensate • Over 3,000 genes changed, with energy pathways shutting down • Antioxidant defenses weakened while stress signals activated After just 10 days of complete inactivity, older adults lost a substantial portion of their mitochondrial mass. Mitochondrial volume density measured by electron microscopy dropped significantly, and citrate synthase activity fell in parallel. But here's the twist: total energy production stayed normal because the remaining mitochondria cranked up their individual output. This sounds like good news. It's not. The compensation comes at a cost. The mitochondria that survived started producing more reactive oxygen species, essentially damaging molecules that your cells normally neutralize with antioxidant systems. Production went up while the cleanup systems got weaker. When damage production outpaces your ability to clear it, problems accumulate. The gene expression data revealed what's happening. More than 3,000 genes changed their activity levels. Genes responsible for building new mitochondria and maintaining energy production all got dialed down. Meanwhile, emergency stress response genes activated. Your muscle is essentially preparing for prolonged shutdown while trying to manage rising damage. This pattern matters because it defines the sequence. Mitochondrial loss and oxidative damage happen first, within 10 days. Actual energy production failure comes later, after the compensation exhausts itself. Previous studies in young adults showed they maintained their mitochondrial content after 10 days of bed rest. Older adults in this study lost it. The age-related difference in resilience to inactivity is significant. Younger muscle can weather short periods of inactivity without shedding mitochondria. Older muscle starts losing them within days. The practical implication: if you're over 65 and face a period of reduced activity from illness, injury, or hospitalization, mitochondrial decline starts almost immediately. The energy production numbers might look fine initially, but you're operating on fewer, overworked mitochondria producing more cellular damage. Once you lose mitochondria, rebuilding them takes time and may be incomplete. This explains why older adults often struggle to return to baseline function after hospitalization or illness. The visible problem is muscle weakness. The underlying driver is mitochondrial loss that happened in the first week or two of inactivity. The intervention window is narrow. Maintaining some level of activity during periods that would otherwise be sedentary, protecting mitochondrial mass before it drops, matters more than trying to rebuild after the fact. For healthy aging, the message is clear: consistency matters more as you age. Younger muscle tolerates gaps in activity. Older muscle doesn't have that buffer. A week or two of complete inactivity triggers changes that weeks or months of training built. The decisions made during short periods of forced inactivity, whether you do simple resistance exercises in bed, walk as soon as possible, or stay completely sedentary, shape the mitochondrial foundation available when you try to resume normal activity. Older muscle operates with less margin for error. The first 10 days of inactivity look deceptively manageable because energy production stays normal. The damage is happening at a level you can't feel yet.

A.I. ISSUES? large language models? thank you so much @dhkbeau

A single session of lifting weights speeds up your brain. The strongest version of you thinks faster too.

its not a friend. but the neck problems are showing up. electric bikes? your kid needs to develop musculoskeletal fitness as a CHILD. full stop. I am getting angry again. fires set off by lazy adults who cannot peddle a normal mountain bike?

AI chatbots are warm, responsive, and always available. But psychologists say those qualities make them poor substitutes for the messy, effortful work of human relationships, especially for adolescents whose social skills are still forming. Learn more: at.apa.org/20f59e

Chatbot-induced disorder should be considered in the differential diagnosis for any new onset or worsening of: -Psychosis -Suicide -Violence -Addictions -Eating Disorders -Mood Disorders -Social Phobia -Conspiracy theory

IS ONE DRIVE DEFECTIVE? No probably not. its irritating to me. I want to find info that way I need it to be... every effing program online or off at grocery stores makes all of us comply to how we need to do stuff. ENOUGH OF IT. relationship programming sucks

ITS WORSE CHATBOTS CAN ACCESS YOUR COOKIES. THAT IS THE RISK OF A.I. NOT THE FOOD IN YOUR CUPBOARD. YOUR PASSWORDS. you name it. disabled onedrive on my PC has programming issue & I am out of patience with it. i will un-install it. see eve fain on linkedIN

A new study puts the microbiome in the spotlight for bile acid malabsorption. 🦠 Researchers found changes in primary bile acids and the gut microbiome after probiotic treatment—but there’s more to the story: gastroendonews.com/a/sz0BAA/… #Microbiome #Gastroenterology

GOOD TO KNOW. we see stuff online. just ask your doctor or use a search engine to find accurate info. I am fresh out of patience on someone giving me advice. I am NOT stupid, have 35 years of clinical care focus. 10 years spent unraveling a ball of yarn.

HOWEVER... when you are arguing nor thinking... have you mapped out your patients glucagon/insulin responses to food. Dr. W. ? expert. It may or may not trigger you to think about cell biology, cell life, how the incretins work TOGETHER to keep us healthy.

will we recover our normal GLP incretins & our GIP production? I am way beyond hawking drugs on X or anywhere else. I have the KEY TO THE CITY. logging off. you can repost or comment. I need to take out my trash

my now dead brother & I got my Great Grandfather's social security # taken off google search. It took 2 of us to get this done. My great Grandfather fought in the Mexican/American War. his homestead was in NM. He would have lost it. 13 KIDS.

FULL STOP get analogy

this physician is amazing & he is an artist also. he & I connected ?? years ago online. I have a strange BRAIN. its connected somewhere & so I understand the depth of pix well. I also read body language; later I think, "what did they say to me"??