Welcome everyone. I wrote a short article about my story, science and what we need to make treatments a reality. Here’s the summary: My wife Jillian had rare ultra-lethal treatment resistant cancer (all TNBC is a multi-gene silencing disease but she had much worse mutations on top).
I switched those genes/receptors back on. First documented in-human genes restored across chromosomes. I couldn't maintain the therapy (which I created in real time as she was dying) due to lacking metabolic control. However it did triple her survival time. I have in the 3.5 years since, improved it.
6 months later at hospice phase I eliminated her cancer stem cell (CSC) molecular pathways, that are involved in all cancers. Dropping all mutations, tumor cells, and proliferation markers in the process. This was also the first documented in-human CSC molecular elimination while concurrently dropping all cancer markers without toxicity. This was done as an isolated treatment but could support standard therapies.
If it was done earlier, I could have saved her. But it was too late - I lost the battle and lost my love. I loved her more than anything. Our 3 babies (ages 1-3) lost their mother. I have raised them myself.
I re-engineered existing FDA approved drugs to have improved bioavailability and biochemical targeting so they could translate preclinical efficacy into clinical efficacy. Everything done, including modulating metabolism, was deeply idiosyncratic and targeted to specific substrates. Ordinary processes wouldn't work. Trying to replicate it from the paper alone will not work (e.g. off the shelf versions of the drugs).
All other therapies aside from mine, including chemotherapies, immunotherapies, natural medicines and repurposed drugs, failed to produce any response whatsoever. They failed on day one - not after some success. And in fact the cancer grew significantly through them.
We had several oncologists, who reviewed IRL our results. They not only ordered the biopsies, those genetic samples are from the top oncology labs used by oncologists (Tempus, Cell Search etc.) it was also independently peer reviewed after the paper published.
My son Arran is my primary focus now. He has dozens of genetic disorders, he has terminal mutations and very severe disabilities (including severe Autism). I do this for him. He is the reason I wrote Jill's paper, so we could build upon it and save him. He is the key to so many. He has some 2B people's disease in one child. He is the most complex genome we have ever seen.
We need to build two separate programs: Gene Reprogramming to correct gene function across diseases, and the CSC therapy to suppress the causal growth of cancer. We are seeking partners to build both asap. Prior partners didn't pan out due to prioritizing patient programs and stewarding development. We need a controlled and safe path forwards so we can universalize it.
-Find more on all this in the article below.
I lost my wife. I am not gonna lose my son as well. This isn't an academic venture it is the highest stakes life event, hence don’t expect trolling debate here. It is all too real for SO MANY outside of biotech, universities and X arguments. We have created a discord community to join for free where people can help one another.
Sorry you're suffering, I'm trying to change why you are. For Arran, for us all. I just want my family to be free from disease again. They say it is impossible, but my modulation of pharmacology and biology did the impossible a couple times before. It is indeed, entirely possible.
P.S. I will be also launching a systems biology class of nutraceuticals very soon to support multiple high level molecular pathways that drive a lot of chronic dysregulation (brain fog, inflammation, immune support, etc.) inspired by my daughter's rare disease/Autism neuroinflammation. Everything I create is family first.
Grok’s confirmation + Medical Records:
nitter.net/grok/status/1984350904…