And if you're interesting in joining us in our adventure into toxicity, germline genetics, and precision safety, consider applying to this open postdoctoral position.
Incredibly excited to report today on the determinants of toxicity to systemic therapy in cancer patients. Led by many including Alex Guo, Feiyang Huang, Saksham Mohan, River Walser, and the fearless @ZiadBakouny. Co-led by Wes Tansey and Jian Carrot-Zhang medrxiv.org/content/10.64898…
We are recruiting a @USouthFlorida undergrad for an internship in artificial intelligence applied to mathematical oncology in my group @MoffittNews.
Interested candidates please send me an email with the details in the link:
labpages.moffitt.org/westj/o…
Really enjoyed talking about T cell exhaustion (and some other things!) with my friend @PatrickHwuMD on his fantastic Immunoverse Podcast!
podcasts.apple.com/us/podcas…
Meeting the first patient who will receive proton therapy at @MoffittNews in just 10 days was a powerful reminder of why my work matters. Looking forward to beginning treatment and bringing this advanced technology closer to home for our community.
My group (EDIT lab) runs a Summer Seminar (EDIT SumS) for postdoc talks, similar to a journal club format. Here's a summary of our first in 2026:
labpages.moffitt.org/westj/S…
Please RT: official post forthcoming, but for those currently hunting for postdocs, my group will have a fully funded position for an individual to lead our activities in computational analysis of radiographic data. If you have those skills and want to dream, please reach out.
@infoecho@domenjemec reviewed Conway's Law and the history of genome assemblers to see how including agents in academic labs will shape the research software ship. PIs will bifurcate further: either they'll ship more or end up even more removed. gptomics.com/blog/conway_law…
As academic audit culture grows (now pre-approvals for conferences, foreign collabs, etc), I hope students will remember there's another way: academia built on mutual trust/obligation through collective effort
My take on the neoliberal academic ecosystem: youtu.be/PGO4qgfm7DU
At #MoffittScientificSymposium, Ada Lau shares research investigating immunosuppressive features of the multiple myeloma tumor microenvironment following CAR-T therapy. Findings revealed CD8+ immune responses between complete response and progressive disease samples, highlighting interferon pathway activation in responders and TNF-alpha signaling in progressive disease.
At #MoffittScientificSymposium, Ada Lau shares research investigating immunosuppressive features of the multiple myeloma tumor microenvironment following CAR-T therapy. Findings revealed CD8+ immune responses between complete response and progressive disease samples, highlighting interferon pathway activation in responders and TNF-alpha signaling in progressive disease.
Science does not have to be complicated: Direct injection of an immune therapy drug into tumour reduces side effects without compromising efficacy. nature.com/articles/d41586-0…
"Why wait 6 months for reviewer 2 when you can get roasted by an #AI in seconds?" A metascientist's thought exercise.
bsky.app/profile/shahanmemon…
Meanwhile, an AI society announces it's incorporating LLMs into its review process.
aaai.org/aaai-launches-ai-po…
When polishing scientific figures for publication, I try to limit fonts + font sizes to reduce visual noise. But doing this by hand is tedious.
So I vibe coded a web app to standardize text in SVGs: jef.works/SVG-Text-Standardi…
Try it out! Spot the differences. Hope it's helpful
#ScienceSaturday
❓ How can we turn T-cells into cancer-fighting “soldiers” without changing their DNA?
➡️ A new study in Nature Biotechnology introduces an all-RNA platform that can turn T-cell genes on or off using epigenetic CRISPR tools called CRISPRoff and CRISPRon. Instead of cutting or rewriting DNA, this method “reprograms” genes by adding or removing chemical marks — allowing researchers to boost or silence key immune functions safely.
➡️ The team showed this can enhance CAR T-cell therapies, helping immune cells better recognize and attack tumors while reducing potential side effects linked to traditional gene editing.
🌟 Congratulations to senior authors Alex Marson, Luke Gilbert, Brian Shy, and Justin Eyquem of UCSF, Arc Institute, and Gladstone Institutes for this exciting advance — a big step toward the next generation of precise, safer immunotherapies.
🔗 Read more in Nature Biotechnology: doi.org/10.1038/s41587-025-0…@LukeGilbertSF@UCSF@UCSFCancer@UCSFMedicine@arcinstitute@GladstoneInst@j_eyquem
A recent special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health.
Learn more: scim.ag/45xh33a