Ceftaroline vs Ceftobiprole:
CEFTAROLINE = MRSA + Pneumococcus + Skin/Lung
Fifth-generation cephalosporin
Binds altered PBP2a → active against MRSA
Strong activity against S. pneumoniae, including resistant strains
Important uses: acute bacterial skin/skin-structure infections and community-acquired bacterial pneumonia
Also covers many common Gram-negative respiratory pathogens
Does NOT reliably cover Pseudomonas
Does NOT cover Enterococcus faecium
CEFTOBIPROLE = MRSA + Pneumococcus + Pseudomonas + E. faecalis
Fifth-generation cephalosporin
Also binds PBP2a → MRSA activity
Broad Gram-positive activity, including Enterococcus faecalis
Broader Gram-negative spectrum than ceftaroline
Importantly, has activity against Pseudomonas aeruginosa, although susceptibility should be confirmed
Used for bacterial pneumonia and certain bloodstream/S. aureus infections, depending on regional approval
Not reliable against E. faecium