New work from the lab shows that a novel non-coding RNA, FAM151B-DT, is a driver of tau and alpha-synuclein aggregation ⁦@washumedicine⁩ ⁦@RCFNeuro⁩ ⁦@WashUMedADRC⁩ nature.com/articles/s41380-0…

A novel lncRNA FAM151B-DT regulates degradation of aggregation prone proteins

Molecular Psychiatry - A novel lncRNA FAM151B-DT regulates degradation of aggregation prone proteins

nature.com
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When looking for lncRNAs that change in FTD, one stood out that was reduced in human neuronal models and in FTD brains: FAM151B-DT 🧠🧫
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Of course FAM151B-DT was poorly characterized, so Arun got to work finding it is cytosolic and interacts with tau, alpha-synuclein, and a ton of proteins involved in protein clearance!

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When FAM151B-DT is silenced, tau and alpha-synuclein levels go up, and we detect more aggregation of these proteins. We think this is because FAM makes it harder for the cell to get the bad proteins into the trash

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Oct 23, 2025 · 1:16 AM UTC

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We can fix it! Adding more FAM151B-DT to cells reduces tau and alpha-synuclein aggregation. Making this a promising target for drug design for FTD and Parkinson’s disease @AFTDHope @MichaelJFoxOrg

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