A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies: Stem Cell Reports cell.com/stem-cell-reports/f…

One unsolicited piece of advice for new #gradstudents. Don't settle on ALL of your #rotations before school starts. Use the first semester to explore. Talk to people! Check out labs and areas that you haven't considered! Go outside of your comfort zone! Let yourself be surprised!

The FDA has cleared a blood test developed from technology invented at WashU Medicine to aid in diagnosing Alzheimer’s disease. The test, PrecivityAD2, can detect amyloid plaque biomarkers with over 90% accuracy. medicine.washu.edu/news/fda-…

APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics: nature.com/articles/s41467-0…

MAPT splicing modulators reduce 4R tau and rescue tauopathy phenotypes in human neurons and in a mouse model | Science Translational Medicine science.org/doi/10.1126/scit…

Happy to share the lab's new work characterizing the impact of a youth-associated protein on microglial function. Congrats to 1st author Brittany Hemmer, w/ excellent contributions f/ @philippi_sarah and all co-authors! @IcahnMountSinai @SinaiBrain Paper: nature.com/articles/s41467-0…

Huge faculty recruitment effort at the University of Chicago -- a division-wide, open-rank search looking to hire about 20 faculty across 5 research areas in biology. Come be our colleague! Full announcement: uchicago.app.box.com/s/ckih9…

Very excited to announce ENCODE GRAMMAR (Genomic Regulatory Atlas of sequence Models, Motifs, Annotations & Rules): 3,865 experiment-specific deep learning model sets and sequence annotations for decoding human regulatory DNA. 1/

Excited to see our work now published science.org/doi/10.1126/scie…! Lysosomal dysfunction has long been considered a hallmark of aging, but we still know remarkably little about what actually changes inside lysosomes as organisms grow old. Using rapid lysosome isolation and metabolomics, we built the first atlas of lysosomal aging across tissues.

How do lipids influence aging? We find that membrane lipid composition impacts neural stem cell aging and 'rejuvenation'! HUGE congratulations to @xiaoaizh on her paper just published at @ScienceAdvances!! 🤩🍾 And a big thank you to all our collaborators! A thread 🧵...

I'm excited to announce that our study, Transcriptional regulation of disease-relevant microglial activation programs, has been published this morning in Neuron: cell.com/neuron/fulltext/S08…. We discovered functional regulators of six microglia activation states!

New pre-print from us! We compare two iPSC-microglia protocols, and take a look at the cell autonomous and non-cell autonomous effects of MAPT mutation: biorxiv.org/content/10.64898…

TDP-43 subtypes shape transcriptomic signatures in Alzheimer's disease biorxiv.org/content/10.64898… @PrudencioLab Excited to share our new transcryptomics study in AD where we use quantiative measures of pathological pTDP-43 and pTau to discern changes resulting from each pathology.

Studying these young Alzheimer's patients led to breakthroughs, but the funding was cut. npr.org/2026/05/07/nx-s1-575…

We are excited to announce that Dr. Ana Maria Cuervo @AMCuervoLab will be our next ISMND webinar speaker! Selective #autophagy: fighting #neurodegeneration one protein at a time May 14, 2026 10-11am (ET) Host: Dr. Hui Zheng Registration: bit.ly/4tXtGzN

🚨 New in Sci Transl Med! science.org/doi/10.1126/scit… Our cross‑fluid proteogenomic study shows <30% of pQTLs are shared between CSF and plasma, revealing why plasma misses key biology. We identify 427 protein–trait (249 new) links. Context matters for target discovery. 🧠🔬

New collaborative study in Nature Medicine! Our AcTau174 antibody powers a sensitive CSF assay from Teunissen lab that cleanly separates FTLD-TDP from FTLD-Tau & tracks cognitive decline in AD & FTLD—enabling subtype-specific clinical trial enrollment nature.com/articles/s41591-0…

Excited to share new work led by Sam Swift in the lab identifying NINL as a modifier of tau seeding alz-journals.onlinelibrary.w…

Chemical compound clears cellular waste, protects neurons in model of frontotemporal dementia source.washu.edu/2026/03/che…

Traditional single cell transcriptomics doesn't capture most non-coding RNAs. In this work, led by @alinaisakovaSci and @StephenQuake, we introduce TotalX, a @10xGenomics-compatible pipeline that captures both coding and non-coding transcripts. Out now in @NatureBiotech! 1/7

Pleased to share our latest study using super resolution to show that a pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia by the amazing Dr Mirfakhar 🔬🧫 nature.com/articles/s41467-0…