Bren Professor of Computational Biology @caltech. Blog at liorpachter.wordpress.com. Tweets represent my views, not my employer's. #methodsmatter
Pasadena, CA
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Lior Pachter retweeted
Please help spread the word! We are recruiting multiple Postdoctoral Fellows as part of the recently launched Bakar Computational Biomedicine Initiative (BCBI) at UC Berkeley and UCSF.
BCBI website: bcbi.berkeley.edu/
Apply by Nov 1, 2026: berkeley.infoready4.com/#fre…
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I highly recommned the essay on antedisciplinary science by Sean Eddy written 21 years ago.
journals.plos.org/ploscompbi…
It seems to me that we are currently experiencing the birth of a new discipline: mathematics engineering.
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I wonder if one of the long-standing math problems OpenAI has solved is the leaky pipeline.
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The @usnews rankings are out again and just a reminder that they never show you the relevant object, which is the polytope (rankings with respect to all weights).
arxiv.org/abs/0805.1026
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Subject coverage of the mathematicians comprising the Advisory Group on Mathematics and Artificial Intelligence.
Subject classifications according to the MSC based on arXiv papers.
We’re working with an independent advisory group of mathematicians to help OpenAI responsibly share advances in AI and mathematics.
The group will advise on how we assess and communicate new mathematical results, uphold academic and professional standards, and build tools that support mathematical research and learning.
Through this work, we want mathematicians to be at the center of shaping how AI supports mathematical understanding and how its benefits reach the wider community.
openai.com/index/advisory-gr…
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All this talk about mathematics being "open" is disingenuous. E.g., the NSA discovers math it does not publish.
Differential cryptanalysis was known at the NSA in 1974 but was only published by Shamir after he discovered it independently in 1991.
dl.acm.org/doi/10.1147/rd.38…
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Nicholas Polson…
Excellent piece by @UChicago President Paul Alivasatos on how to integrate AI into their revised core curriculum. Sounds good to me!
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Maybe parents should just use a random embryo and with the savings purchase an RTX5090 card along with a frontier model subscription to give the baby when it's born.
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In 1999, David Haussler, Richard Karp and I met here to discuss strategies for assembling the human genome. berkeleyside.org/2026/09/18/…
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"others" as an author is a great riddle. It could be one person or the entire human population (~8.3 billion). Or it could be a machine (say codex or claude?) Or it could be a dog whose paw was used to press the `return` key.
We'll never know!!
Source: yifzhang.com/blog/KLPO/#cita…
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"...this model has now resolved more than 100 long-standing open problems across most areas of mathematics."
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You hire a roofer to replace an old roof. The work is terrible and rushed using surplus tiles and improper nailing. A month later in light rain it leaks.
In a Yelp review must you stick to describing problems with improper nailing or is it ok to also complain about the roofer?
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Five years ago I wrote about the "amoral nonsense of Orchid's embryo selection". Since then, the amoral nonsense has multiplied with companies doubling and tripling down, new companies launched, and an overall booming industry.
Super depressing.
liorpachter.wordpress.com/20…
"Humanity can too"? Their IQ analysis is massively inflated by an assumption their own source told them not to make! 1/
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Lior Pachter retweeted
I wonder if cherry picking results, exaggerating results, hyping, not being honest about limitations, not sharing data or code were the best practices? 6/
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"Humanity can too"? Their IQ analysis is massively inflated by an assumption their own source told them not to make! 1/
AI is rapidly getting smarter.
Now, humanity can too.
Today, @nucleusgenomics is announcing Vitruvian, our newest set of genetic optimization models.
Vitruvian’s intelligence model can optimize embryo DNA for 14 IQ points — nearly a standard deviation.
The models were trained on 1,000,000+ people, validated across 40,000+ siblings, and used more than 7 million genetic markers.
In Superintelligence, Nick Bostrom proposed genetic optimization as a key way for humanity to keep pace with rapidly advancing AI.
Bostrom’s vision is no longer theoretical.
Genetic optimization, like AI, has followed a scaling law: as datasets have grown, so have model capabilities. This trend will continue.
Parents across the world now have the choice to substantially increase their child’s intelligence.
And the next generation can choose to do the same.
AI is no longer the only intelligence that will compound.
Humanity can now direct its own evolution.
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Apply an assortative mating correction using published estimates and the IQ spread drops by ~20%. But that's just a guess.. If Nucleus has 20,000 sub pairs they could produce a more exact estimate. So why didn't they? 5/
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