i like brains. Neurology ACF. Previously @The_MRC Clinical Research Training Fellow

Londoner
New paper out in Alzheimer's & Dementia 🧠 We combined resting-state pupillometry-fMRI, neuromelanin MRI of the locus coeruleus, and cognitive testing in 64 people with Alzheimer's and 26 controls to ask how arousal shapes cortical dynamics in AD. 🧵
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Michael David retweeted
Full interview on the Manchester City case below.
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Michael David retweeted
Yesterday I joined leading figures from the world of sport at Lord’s Cricket Ground to support Alzheimer’s Society. One million people in the UK are living with dementia, now the country’s leading cause of death. or to learn more about Alzheimer’s visit alzheimers.org.uk/sport
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Michael David retweeted
The Premier League on the other hand fought a lengthy + expensive legal arbitration against City to force them to disclose ALL relevant documents. Long story short, City fought it at every level and lost…
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Michael David retweeted
“Most countries have been slow to realise just how threatened they are by the weaponisation of collective stupidity”. @GeoffMulgan writes for @ArguablyMag on what “cognitive rearmament” would look like and why you should care about it. arguably.uk/p/collective-stu…
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Michael David retweeted
The latest episode of the Brain podcast-out now! Listen at: traffic.libsyn.com/ec9881f0-… Featuring discussion with senior author Professor Gültekin Tamgüney on: Vaccines mimicking conformational epitopes on α-synuclein fibrils provide immunity to Parkinson’s disease
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Michael David retweeted
Tony Pulis knows everybody in football
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One of England's most charismatic, joyful cricketers, a World Cup winner, an Ashes winner, and probably their fastest ever bowler. 🫡
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People say there are fewer world class players as there were in previous generations but has there every been a better selection of wingers as Mbappe Yamal Kvara Olisse?
Ballon d’Or or not, this is the best footballer on the planet.
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Gambling should not be legal, obviously.
The gambling industry only has itself to blame that we are finally responding to the harm it causes, including mental ill-health & suicide. They have resisted reform every step of the way.
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Michael David retweeted
An extraordinary @Nature paper has just landed from the lab of @Sergiu_P_Pasca at @Stanford - led by Konstantin Kaganovsky. They have found a way to create "xenocortical mice" which have ~92% of their cortex occupied by a cortical organoid derived from human stem cells. This human-derived cortical graft integrates deeply with the host nervous system, supporting organised neural activity and behaviour. This study is a milestone in synthetic biology and chimera research. It has the potential to generate multiple medical breakthroughs by providing an enhanced biological model of human brain tissue that allows behavioural as well as neural and genetic assays. The Stanford team have been exceptionally thorough and proactive in addressing ethical concerns that comes from this frontier work. But their pioneering work nonetheless raises many open questions: are the xenocortical mice conscious? Do they have any human-like properties of consciousness or cognition? @NitaFarahany and I will be addressing some of these questions in a forthcoming commentary - where we'll also offer an ethically-informed roadmap to guide this important research as it progresses. In this context, "pacing the frontier" really does make sense 😉 Read the Stanford @nature paper here, and buckle up. It's wild. nature.com/articles/s41586-0…
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Think @lukeaaronmoore really missing the point on the excellent @FootballRamble . The issue with the laws is not that some weirdo execs are the ones writing them. The issue is that if you try to write some meticulous thorough law, you will end up with inconsistency and confusion.
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Either you accept that fact and allow subjectivity of the ref. Or you make it endlessly more complicated in the hope that you’ve provided an objective answer to every scenario which the ref/VAR will be able to apply perfectly - we’ve proven that the latter does not work.
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10+10 would do nicely
How many is Bradley Barcola grabbing this season for Liverpool? 🤔
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It’s interesting how often these graphs reveal massive outliers
13 - Lamine Yamal has created the most chances in Europe's big-five leagues in 2026-27 so far (13), while only Kylian Mbappé has had more shots than he has. Output.
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Michael David retweeted
Lovely example of incrementally beneficial steps in cancer medicine. Dementia barely at the start of this process.
NEW content online! The long return on discovery science in cancer therapeutics dlvr.it/TVCjdd
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Joshua Kimmich solves all of our problems.
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