UCSF’s Kevan Shokat, PhD, just won the $1M Stephenson Global Prize for research in pancreatic cancer. He cracked KRAS, a cancer driver long considered “undruggable.” Drugs built on his work now treat lung and pancreatic cancer. ow.ly/xVlw50ZRSXh
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Mike Thompson, MD, PhD, FASCO retweeted
Replying to @RahulBanerjeeMD
@RahulBanerjeeMD @DrPMPGI @IMS2026....The spiderman drove straight the take home message..enjoyed the debate ..
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Mike Thompson, MD, PhD, FASCO retweeted
BCMA×GPRC5D dual-targeted CAR-T therapy BMS-986453 showed >90% response rates at two dose levels in ongoing first-in-human early-phase trial, w/ 100% response 100% MRD-negativity in BCMA/GPRC5d-naïve pts --- Doris Hansen, MD #IMS26
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Behind on #IMS26 coverage? 👀 Catch up with our daily recaps and exclusive insights from experts, live from Glasgow. hubs.ly/Q04ylRTc0
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Mike Thompson, MD, PhD, FASCO retweeted
No!! The cure definition is aspirational. Stopping maintenance for any patient is a decision that’s made based on the patient’s unique clinical situation, myeloma risk features, the treatment administered, duration and depth of MRD negativity, data on duration of maintenance by drug that we have available etc. Not a decision to be taken lightly.
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Mike Thompson, MD, PhD, FASCO retweeted
💯 ORR and 100% MRD negativity among evaluable pts in bcma naive pts, wow! With dual CarT presented by @DorisKHansen #IMS26
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Mike Thompson, MD, PhD, FASCO retweeted
IsaVRD vs IsaRD A critical question not answered by any registrational trial of NDMM with CD38 directed Abs. Love the use of RMST ! Thnx for doing that; a much better marker than absolute PFS We all agree HRMM need more; but may he Std Risk MM does not need bortezmib and related neuropathy. We seeing these of projecting 10 yrs out !! #MMSM #IMS26 @Myeloma_Society
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Mike Thompson, MD, PhD, FASCO retweeted
RAS ON!
Read: "RAS Pathway Activation Is a Hallmark of Myeloid Sarcoma," by authors Bettina Nadorp, Audrey Lasry, Sanam Loghavi, Iannis Aifantis, and Ann-Kathrin Eisfeld. aacrjournals.org/bloodcancer… @BettinaNadorp @audrey_lasry @sanamloghavi @iannisaifantis1 @AkEisfeld
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Mike Thompson, MD, PhD, FASCO retweeted
Great presentation of EXCALIBER RRMM by Sagar Lonial
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Mike Thompson, MD, PhD, FASCO retweeted
Huge thanks to @HealthTree @PeerView and @Myeloma_Society for allowing me the privilege to talk about immunotherapy sequencing and Oreo cookies at #IMS26. This has been such a wonderful congress ! #mmsm @TischCancer
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Mike Thompson, MD, PhD, FASCO retweeted
Official drink of #IMS26 in 🏴󠁧󠁢󠁳󠁣󠁴󠁿, home to the first James Bond actor! “Sequenced, not stirred” - the best of CAR-T and BsAb in myeloma come when both are intentionally available sequentially. CAR-T ➡️ BsAb beats CAR-T alone even knowing post-CAR-T relapses often end poorly.
Read this recent spotlight by #IMS26 speaker Rahul Banerjee, “Sequenced, Not Stirred: Positioning CAR T and Bispecific Antibody Therapy in Multiple Myeloma.” aacrjournals.org/bloodcancer… @rahulbanerjeeMD
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In the realm of the “e-Patient” it is key to not underestimate your audience [Jul 11, 2017] Sem Hematol ow.ly/gDA130dJre2 #mmsm
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Twitter 101 & beyond: Intro to social media platforms available to practicing #hemeonc [Jul 11, 2017] @mtmdphd @AhlstromJenny @drdonsdizon @DrYashGad @chimoose @hjluks @andrewschorr Sem Hematol ow.ly/gDA130dJre2 #mmsm
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Schooling Herself & Others on Myeloma..." @MyelomaTeacher is a social media rock star" [Aug 25, 2015] @AACR ow.ly/RZGKR #mmsm HT @DanaHolmes911
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Mike Thompson, MD, PhD, FASCO retweeted
#IMS26 @SagarLonialMD presenting EXCALIBER-RRMM. Finally, the Iber-Dd CELMoD data we've been eagerly awaiting! Rationale for presenting now, he just explained: Request from 🇺🇸 FDA not to release MRD-CR-based data before their formal approval. This is why I attend conferences!
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Organizing Online Health Content: Developing Hashtag Collections for Healthier Internet-Based People and Communities [Jun 28, 2019] @subatomicdoc et al. @JCOCCI_ASCO ow.ly/AxNP30p1P6g #ayacsm #bcsm #btsm #gyncsm #lcsm #mmsm #pancsm
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Organizing Online Health Content: Developing Hashtag Collections... [6/28/19] - @subatomicdoc @pfanderson @mtmdphd @TheLizArmy @JFreemanDaily @audvin @drdonsdizon @CBlotner_ @DavidCookeMD @womenofteal @stales @fischmd @colleen_young @DrAttai @JCOCCI_ASCO ow.ly/AxNP30p1P6g
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Mike Thompson, MD, PhD, FASCO retweeted
First RCT results of Etentamig (BCMA bispecifc antibody) presented at Plenary Session #IMS26 @Myeloma_Society @PlasmaCellPete @myelomaMD 60 mg fixed dose every 4 weeks makes this the easiest bispecific to administer. Impressive PFS benefit in relapsed refractory myeloma with at least 2 prior lines of therapy. See thread for more details.
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I find it instructive to look at how FDA-approved cancer medicines behaved in preclinical studies - Clinically effective therapies usually *shrink* tumors in vivo, for a long time, at a modest dose, not just slow growth by a few days
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