An online resource for researchers studying and using organoids. Part of the @STEMCELLTech Science News service.
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Researchers established a transplantation platform using a genetic strategy to effectively deplete glutamatergic #neurons from mouse 🐭 neocortex and hippocampus and neonatally engraft the cortical cavity with human stem-cell-derived cortical organoids 🧫 to generate #xenocortical mice.
Lean more: go.nature.com/4yegEQt
@Nature | #OpenAccess
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Researchers provided an organoid-based 🧫 platform for mechanistic investigation and personalized intrathecal therapy screening and proposed triple intrathecal therapy as a promising translational strategy for #DiffuseMidlineGliomas.
🔗 bit.ly/3SN4NcM | @CellCellPress
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#Organoid monocultures' lack of immune components means that they fail to show how immune cells shape epithelial identity.
Researchers created a new platform for studying epithelial-immune interactions by co-culturing macrophages in the intestinal niche: bit.ly/45URzNO
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The Park lab (@Inhyun_P) at @Yale has identified DEAF1 as a critical regulator of #neurodevelopment. Mutations in DEAF1 leads to significant transcriptional alterations in human #CorticalOrganoids.
See the paper in @ScienceAdvances: bit.ly/4xrPmEQ
📖 #OpenAccess
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💸 @GreenstoneBio has been awarded a Breakthrough T1D Industry Discovery and Development Partnership grant to develop a T1D-derived islet cell platform aimed at understanding and protecting insulin-producing β cells in people with #Type1Diabetes.
Learn more: bwnews.pr/4AdMSwr
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#BrainOrganoids 🧠 can simulate critical processes of human neurodevelopment in both physiological and pathological states, providing an unprecedented window into the mechanisms and potential therapeutics of #AutismSpectrumDisorder.
▶️ Learn more: go.nature.com/46gD6MA
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Investigators suggested that #trastuzumab treatment is associated with ferroptosis-related biochemical and molecular alterations in #HER2-positive breast cancer organoids, and that #p53-related signaling may participate in this process.
💡: bit.ly/4zU6cia
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Analyze your #organoids SWIFT-ly!
🔎 This new workflow, SWIFT, from @EPFL uncovers dynamic Wnt-dependent morphological transitions, enabling scalable, high-throughput studies of epithelial plasticity: go.nature.com/4qYjGFN
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Researchers developed vascularized #LungOrganoids from human iPSCs that model key features of COPD and pulmonary hypertension, providing a platform for disease research and precision drug discovery.
Learn more here:
▶️ bit.ly/4h9Ubgf
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Drs. @IreneFaravelli, Noelia Antón-Bolaños (@BolanosAnton), Paola Arlotta (@ArlottaLab), and colleagues from @Harvard and @broadinstitute demonstrated that #BrainOrganoids 🧠 transcriptionally age with cell type specificity over years in culture.
Check out this article in @Nature:
🔖 go.nature.com/4zIkDWC
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Scientists with Ozge Ardicli investigated the molecular and functional consequences of sodium dodecyl sulfate and cocamidopropyl betaine exposure in primary #eosinophilic esophagitis-derived esophageal #organoids and air-liquid interface cultures derived from biopsy tissue samples. 🧫
📚: bit.ly/4gpLdfv
#OpenAccess 🔓
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This review addresses the critical need for standardization in cartilage organoid research.
The authors summarize the defining features of #CartilageOrganoids and distinguish them from related cartilage models.
bit.ly/4goQDHB
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#LiverOrganoids: From disease modeling to regenerative medicine.
This review summarizes current fabrication strategies, disease-modeling utilities, and regenerative potentials of liver organoids.
bit.ly/46lNZwq
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University of Basel scientists including Dr. Sandro Nuciforo and Markus Heim established a biobank of patient-derived #HepatocellularCarcinoma (HCC) organoids generated from diagnostic biopsies, capturing the diversity of clinical features across disease stages. 🧫 bit.ly/4xnWZNy
🔓 #OpenAccess #Organoids
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New in @cellrep! 💡
Scientists combine single-cell and spatial #genomics with patient-derived #organoids and tumor samples to show how increased HMGB2 availability represents a transcriptional addiction that fuels cell-cycle progression and growth. 🧫
🔗: bit.ly/4xZQobN
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New projects to move UK science away from animal testing. 🧫
The UK government is investing £22 million to advance alternatives to animal testing, including human #organoids, lab-grown tissue models, and AI-based drug testing.
Learn more here:
📰 bit.ly/4zqLKFz
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Researchers highlight how #organoids and #assembloids could help decode interoception, the brain’s “sixth sense” by modeling communication between the brain 🧠 and internal organs 🫁.
🔖 go.nature.com/3TXzuw5
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Researchers from the @NatEyeInstitute developed a simple 3D-printed stirred bioreactor that improves retinal #organoid yield, quality, and consistency by maintaining physiological oxygen levels during differentiation.
bit.ly/4atpIHt
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Dr. Caroline Vissers and colleagues at @UCSF used human cortical #organoids to reveal a human-specific role for METTL5 in neurodevelopment, linking METTL5 loss to impaired neural progenitor growth and CHCHD2-dependent mitochondrial metabolism.
bit.ly/4wFVxoH
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Scientists from the Hippenmeyer group at @ISTAustria established mosaic analysis with double markers technology in mESCs to probe radial glial progenitor lineage progression in a self-organizing cortical #organoid system.
Discover more via @Nature:
🔖 go.nature.com/4zmn54P
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