Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infection. In @TheLancetInfDis, authors summarise RSV preventive products, real-world effectiveness and uptake, and the opportunity of using communication in translating RSV prevention into impact: spkl.io/60177Z1cx

Grant applications have become a lottery. A 60% growth in applications to one of the world’s most prestigious research-grant programs is resulting in an exceptionally low success rate I think this is one of the major problems of AI--it's creating tsunami of grant applications and turning the decision process into chaos. Grant decisions already felt fairly random and this seems to make the system worse. nature.com/articles/d41586-0…

Seeing a potential benefit of high blood sugar is unusual, to say the least. High blood glucose improved T cell (CD8+) function to take on cancer, in experimental models and in vitro with human cells, with a mechanistic explanation academic.oup.com/jimmunol/ar…

Obama is now our Grandpresident. He doesn't president us directly, but shows up every now and then with jokes and stories and little gifts, and it really pisses off Trump when we ask if we can just stay and live with Obama instead.

The spread of gram-negative antimicrobial resistance is driven by human, environmental, and other factors. Pranita D. Tamma, MD, reviews clinically important pathogens, mechanisms driving resistance, and strategies for treatment. Read the Review Article “Gram-Negative Bacterial Resistance”: nej.md/4yIbmfe

Lots of debate this week on whether journals should ban AI in peer review. We actually tested this in our new preprint, and the results were pretty clear to me. For context, I've reviewed for most of the big journals and evaluated 1,000 human reviews as an editor. I love to read and evaluate science. TLDR: From now on I won't do any peer review without AI. For clinical trials, I'd even call human-only review dangerous 🧵

🆕💥🔴 Review Article @PharmacoJournal Cefepime-Zidebactam: Leveraging β-Lactam Enhancement Against Difficult-to-Treat and Metallo-β-Lactamase-Producing Gram-Negative Pathogens #idxposts accpjournals.onlinelibrary.w…

🆕🔥Excellent Review by @ErinMcCreary + many 🌟s Global epidemiology and treatment of metallo-β-lactamase-producing gram-negative pathogens #idxposts #NDM #MBL academic.oup.com/jacamr/arti…

As an Editor, in past ~6mo, we are receiving an avalanche of unsolicited review articles (“scoping” “systematic”, narrative, NOS) on topics and ?s NO ONE EVER has asked and clearly with heavy AI lift. Even the cover letters all read the same…alarming and sad. #publishing

🧫🟢 ¿Por qué un hongo puede ser "susceptible" en el laboratorio 🔬, pero el paciente no mejora? 🏥🤔 📖 The Lancet Infectious Diseases explica por qué la concentración mínima inhibitoria (CMI) no predice por sí sola la respuesta clínica. #Micología #Antifúngicos 🍄🧬 La respuesta depende de múltiples factores: 🔬 Especie fúngica 💊 Exposición al antifúngico 📍 Foco de infección 🦠 Biopelículas y persistencia 🛡️ Inmunidad del paciente 📊 Los autores proponen un algoritmo para investigar las discrepancias entre laboratorio y evolución clínica. 🩺🔍 ¿Qué hacer? ✅ Integrar datos clínicos y farmacocinéticos. 💊 Monitorizar el antifúngico cuando esté indicado. 🎯 Controlar el foco infeccioso. 💡 👇🏻 doi.org/10.1016/S1473-3099(2… #Microbiología #InfeccionesFúngicas @SEMicrobiologia

Disruption of cAMP Signalling and RNA Regulation Confers Cefiderocol Resistance in Acinetobacter baumannii - more complexities in susceptibility testing and treatment of these tricky pathogens ... @fordebm @LabSchembri @davidantibiotic biorxiv.org/content/10.64898…

Apparently Russian servers have been hit by a Ukrainian strike and immediately massive online hard right chatter has collapsed. This particular chatter was in support of Germany’s AFD, their equivalent to Reform, but similar patterns are being seen in hard right movements everywhere, including the UK. If anyone needed anymore evidence that Russia are driving a massive wave of hard right propaganda in Europe, this is it. So, all you “patriots” - you’ve been duped by Russia, and you are about as far from patriotic as anyone can be. You are easily brainwashed though. This is how propaganda works.

When Ukraine destroys Russian data centers, hoards of aggressive right-wing bots disappear, and Twitter becomes much friendlier. Isn’t that interesting? So much of our politics is driven by the internet, and so much of the internet is driven by Russians who want to hurt us. Shouldn’t we do something about that, given that we know it?

Cross-species convergence of surface polysaccharides shapes the virulence of an atypical carbapenem resistant uropathogenic E coli clone. @LabSchembri @UQ_News @fordebm biorxiv.org/content/10.64898…

Incredible work [and nice to see my Bristol NHS colleagues names in the NEJM]. It seems shorter is better in this setting [quite a lot of AE in longer duration pop]

How good are LLMs at antimicrobial stewardship (AMS)? Wrong question. We wanted to know where they fail. So we built 30 scenarios mapped to the ESCMID prescribing and AMS competencies, and we designed them to break the models (traps). 🧵 clinicalmicrobiologyandinfec… 1/17

📢 Register now for CRE RESPOND's upcoming seminar: Early Diagnostics: An Update on Metagenomics Featuring: 🧬 Dr Mariana Liborio 🧬 Dr Cameron Buckley 🎤 Chair: A/Prof Patrick Harris (@padstamundo) Explore how metagenomics is transforming infectious disease diagnosis and patient care. 📅 15 October 2026 | 12pm-1pm 📍Frazer Institute, Herston or online via Zoom Register now: bit.ly/4zUu70P #Metagenomics #Diagnostics #AntimicrobialResistance #Research

How much does AMR cost in lives and have we been underestimating it? Across 41 hospitals in 19 Asian countries/regions, 74% of 9,642 HAI episodes involved resistant bacteria. Mortality reached 51% with CRAB. ACORN-HAI: pubmed.ncbi.nlm.nih.gov/4262… #AMR #IDxPosts #stewardship

A Clinical Case of Treatment-Emergent Acinetobacter baumannii Non-Susceptibility to Sulbactam-Durlobactam 🔁 Repost 🔗 bit.ly/4pCI4fm

Banho diário com clorexidina em UTI reduz infecções nosocomiais? O CLEAN-IT testou essa estratégia em quase 16 mil pacientes de 22 UTIs brasileiras. O resultado é menos óbvio do que parece — e traz uma discussão importante sobre resistência antimicrobiana. Segue o fio... 🧵