Our latest manuscript is finally out in @NatureSMB! Here, we show that the GAP activity of SEAC (GATOR) acts as a molecular switch, regulating both inhibition and reactivation of TORC1 upon changes in amino acid levels. nature.com/articles/s41594-0…

Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex

Nature Structural & Molecular Biology - Tafur et al. determined the cryo-electron microscopy structure of the SEA complex (GATOR) bound to its substrate, the EGO complex (Ragulator–Rag),...

nature.com

Feb 12, 2026 · 5:20 PM UTC

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Replying to @structureltp @NatureSMB
Congrats! 👏👏🎉🎉
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Replying to @structureltp @NatureSMB
Why is this protein complex lowkey kinda scary looking
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