Deal Sourcing & Portfolio Management tools for Private Investors
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Clinical Development 🏥
Making trials faster, smarter & cheaper.
@PIHealthSc24325 – AI-run clinical trials
@Triomicsinc – AI for oncology trials
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💊 Big Pharma is making billion-dollar bets on AI-designed drugs.
→ Lilly, @Novartis & J&J partnered with @IsomorphicLabs
→ Lilly launched a major AI drug discovery initiative with NVIDIA
We mapped 110+ startups across 8 layers of the AI drug discovery stack 👇
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ALT AI in Drug Development Stack 2026
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Two of the most credentialed researchers in AI just raised $2B betting on what comes next.
The question now: can they act in the real world?
This week's Tip-Offs spotlights World Models and the architects of the post-transformer era →
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ALT Tip-Off #33 by Synaptic
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🧑💻 AI Agent Infra Founders
Newly minted founders building the infra layer for AI agents.
▪️ Abhinav Sinha (@LucidicAI)
▪️ Xiangkai Zeng (@Klavis_AI)
▪️ Remy Tuyeras (Summoner)
▪️ @mjamei (@veris_ai)
▪️ Sandra Tang (@agenthublabs)
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🛡️ AI Security & Governance Startups
Ranked by website visit growth over the past 3 months.
▪️ @PromptArmor | 3603% growth
▪️ @getdelve | 156% growth
▪️ @xygeni | 146% growth
▪️ @nexos_ai | 79% growth
▪️ @PortkeyAI | 78% growth
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🦾 The age of physical intelligence is here.
AI is moving beyond text & images into the physical world, powering robots with perception, reasoning & action.
We mapped 90+ leading startups across 6 key layers.
This is the stack pioneering Physical AI in 2026 👇
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ALT Physical AI Market Map
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For VCs, the right stack can speed up sourcing, cut diligence time & scale portfolio support.
We built the most comprehensive list of VC tools for 2026. 500+ tools mapped across the entire investment lifecycle.
Check them out👇
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ALT VC Took Stack 2026
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🛠️ Developer Darlings
Startups with sensational GitHub traction
Anomaly Innovations | 51% growth
@daytonaio | 36% growth
@lingodotdev | 33% growth
@SimularAI | 21% growth
@nexa_ai | 19% growth
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🚀 Rising Apps
Apps riding remarkable growth on PlayStore
Orion Arm | 66× growth
Jolibox | 8x growth
Audicate | 7x growth
Adrock Advertisement | 6x growth
@OutsmartedPlay | 0.5x growth
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Tip-Offs #25 is here! Your weekly research surfacing promising startups & founders through data signals.
This week’s Highlights ⤵️
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🎙️ Talking to AI no longer feels like talking to a machine.
Today, AI can handle interruptions, remember context, and sound remarkably human.
We mapped 75+ startups building the Voice AI stack right now.
Here's the breakdown 👇
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ALT Voice AI | Market Map by Synaptic
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New year, new startups worth watching!🕵️♀️
Video startups exploding in traffic, teams scaling fast, and veteran operators building in AI.
All this and more in Tip-Offs #21, your weekly research tracking promising startups & founders.
This week’s highlights ➡️
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🧙🏻♂️ Veteran Founders
Industry veterans building AI startups in 2025
Emma Burrows (Portia AI)
Danny S. Dang (AnySoft)
@ed_piliposyan (@modelencecom)
@MaxHappyverse (@HappyverseAI)
@joaopdepaula (@MesmerLabs)
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🧠 DeepMind DNA
Ex-Google DeepMind PhDs starting up (last 18 months)
Shumeet Baluja (POETIQ - safe AGI)
Toby Shevlane (@_Mantic_AI - AI forecasting)
@davidmbudden (PingYou)
@jjh (@elefantai - AI agents for 3D worlds)
@PouyaSamangouei (Stealth)
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💰 Open Source AI raised $3.5B+ in 2025!
Mega rounds, billion-dollar valuations, and early bets fueling infra + observability.
Here are the startups leading the pack across five key segments.
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The race to own AI infra is on! 🏃♀️Startup activity is hot in Observability.
Early pioneers like @arizeai & @fiddler_ai are evolving from basic monitoring to full-stack observability, powering continuous model evaluation & governance. @nvidia & @AnthropicAI fuel growth via M&A.
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💸 VCs doubled down on open source AI infra in 2025: $3.5B+ raised. @supabase ($100M), @MistralAI (€1.7B) & @baseten ($150M) headlined mega rounds, while early-stage bets went to observability & orchestration startups like @promptlayer, @fiddler_ai, & @llama_index.
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