Father of 4 boys, cardiologist, clinical researcher- outcomes, clinical trials, health policy & innovative methods; Director DCRI; Vice Dean, Duke School of Med

Duke University
Fun baseball.. this weekend almost hit for the cycle - single, double and triple then game ended before his 4th AB
Collin Hernandez ('29, SC)⬇️ Relaxed semi-open stance w/ small LL, Keeps BP level, Hands Fire through the zone, Sends this one to the RCF gap for a 2B. #CLTFall | @sox_carolina 👤 play.ps-baseball.com/player-…
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Adrian “WE NEED RCTS!” Hernandez retweeted
The DCRI will lead the SYMPHONY Consortium, a national network testing AI agents for heart failure care across diverse health systems and rural sites. The goal: determine whether these tools are safe, effective, equitable, and scalable. duke.is/m/rw9v @american_heart
Nearly half of U.S. counties have ZERO cardiologists. Millions of Americans have no access to cardiovascular care. And every year, there are 200,00+ preventable deaths from cardiovascular disease. ARPA-H is ending this with ADVOCATE. We’ve picked the teams building an FDA-authorized AI system for real-world heart care. Building toward an AI cardiologist for every American—always ready, clinically trusted, specialist-backed. Not tweaking the old system. Building the next one. Learn more ➡️ arpa-h.gov/explore-funding/p…
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Adrian “WE NEED RCTS!” Hernandez retweeted
Ahead of Beyond the Endpoint’s Sept. 9 episode reflecting on 30 years of the DCRI, founder Robert Califf and current executive director Adrian Hernandez play a game of "what kind of bread are you?" Multigrain, sourdough, ciabatta...watch to find out who's who. 🍞
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So humbling and so true! And why it’s important to have the definitive trials. While #ai can do many things #hi (human intelligence) means testing our best hypotheses…especially when we’re aiming to improve health outcomes.
🧪➡️💊 Going from discovery ➡️ improved CV outcomes in RCTs is very very challenging 20+ once-promising CV targets, oral GP IIb/IIIa, CB1, PDE-3, niacin, Lp-PLA2, aliskiren, all failed or harmed in major CV outcome trials ❌📉 A validated mechanism ≠ a proven therapy ❤️🔬
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Important point…. Different molecules can act differently Will be interesting to see how all of the data unfolds
WOW! Hopefully this quote bodes well for other efforts: “The findings provide important new evidence on the relationship between Lp(a) lowering and cardiovascular outcomes.” And remember, ASOs are NOT RNAi! novartis.com/news/media-rele…
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WOW! Hopefully this quote bodes well for other efforts: “The findings provide important new evidence on the relationship between Lp(a) lowering and cardiovascular outcomes.” And remember, ASOs are NOT RNAi! novartis.com/news/media-rele…
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Wow! Mother Nature is always tricky! #clinical trial randomization > Mendelian randomization
Breaking and MASSIVE: Lowering Lp(a) with #pelacarsen in patients with elevated Lp(a) and heart disease does NOT improve cardiovascular outcomes in Phase 3 trial globenewswire.com/news-relea…
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Congrats @embimd What a great choice for @NIH !!
NEWS: Physician-scientist and informatics leader Dr. Peter Embí to helm NIH’s National Library of Medicine. Read the full story ➡️ bit.ly/4qNApeB
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💬 Editorial by @JAMAplusTrials Editor in Chief Alison J. Huang, MD, MAS, Thomas G. Travison, PhD, and JAMA Senior Editor Derek C. Angus, MD, MPH: #PragmaticTrials are intended to support real-world clinical decision-making, but the term is used inconsistently across studies. A pragmatic orientation may improve the applicability of #ClinicalTrials to routine care, yet it does not justify weaker methods or reduced rigor. 📣 This September’s JAMA+ Trials Theme of the Month examines ongoing confusion and debate in pragmatic trial research, including how eligibility, intervention delivery, outcome assessment, and analysis align with pragmatic goals. Clearer design and reporting may help clinicians and health systems judge whether trial findings are usable in practice. 🔗 ja.ma/4x2jpmk
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Congrats @SusheelKodaliMD Great choice
We’re happy to welcome @SusheelKodaliMD as director of interventional cardiology and our Cardiac Catheterization Laboratory! A world-renowned leader in cardiac care, he's helped advance TAVR and other treatments for complex heart valve conditions: bit.ly/4y3fl6c
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Great choice! Congrats @SVRaoMD
We’re pleased to announce that @SVRaoMD has been named director of the Leon H. Charney Division of Cardiology, where he’ll oversee clinical care, research, and education while advancing innovation in cardiovascular medicine. Learn more about Dr. Rao: bit.ly/3SAav1t
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Adrian “WE NEED RCTS!” Hernandez retweeted
Dr. Marat Fudim and Dr. C. Michael Gibson discuss the MUSIC-HFpEF trial: Data from the first-in-human Phase 1/2a trial demonstrated that single intracoronary infusion of AAV1.SERCA2A was safe and associated with reductions in resting and exercise-induced PCWP in patients with hemodynamically confirmed HFpEF. Watch video here: clinicaltrialresults.org/wp-…
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Adrian “WE NEED RCTS!” Hernandez retweeted
📣 In this week's PCT Grand Rounds, Haider Warraich of @ARPA_H will present “Evaluating Clinical Agentic AI.” Join us! #pctgr 🔗 duke.is/pctnews20260826
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NEWS: Dr. Wendy Weber to serve as director of the National Center for Complementary and Integrative Health. Read the full story ➡️ bit.ly/45L1N3q
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Outstanding group of people ! Congrats to all and @gcfmd who has contributed many lifetimes towards improving quality of care and outcomes across the spectrum of heart failure!
Congratulations to the 2026 HFSA Award recipients! 🏆 We're proud to recognize the individuals and teams whose leadership, innovation, research, mentorship & service are advancing heart failure care. Meet the honorees being recognized at #HFSA2026: hfsa.org/members-and-leaders…
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Adrian “WE NEED RCTS!” Hernandez retweeted
The CardioHealth Alliance is excited to welcome UCLA Health as a new health system collaborator! 🎉UCLA Health’s support will help advance efforts to develop and implement groundbreaking research initiatives aimed at improving cardiometabolic outcomes: cardiohealthalliance.org/new…
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Congrats to DCRI's Mark Darby, whose stunning Emerald Isle sunrise photo was selected as the latest winner of @WorkingatDuke’s Duke Time Off photo contest! See Mark's photo and learn how Duke faculty and staff can participate: today.duke.edu/2026/06/sunri…
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Adrian “WE NEED RCTS!” Hernandez retweeted
Looking forward to Co-Chairing this exciting Think Tank on HF prevention with the incomparable @JavedButler1
The DCRI and @CVCTForum have launched "Pathway to Prevention," an initiative to build regulatory and clinical pathways for cardiovascular prevention therapies. Three programs + multiple stakeholders = closing the gap between science and policy. dcri.org/news/dcri-cvct-laun… #Prevention
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Adrian “WE NEED RCTS!” Hernandez retweeted
The DCRI and @CVCTForum have launched "Pathway to Prevention," an initiative to build regulatory and clinical pathways for cardiovascular prevention therapies. Three programs + multiple stakeholders = closing the gap between science and policy. dcri.org/news/dcri-cvct-laun… #Prevention
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