💬 Editorial by
@JAMAplusTrials Editor in Chief Alison J. Huang, MD, MAS, Thomas G. Travison, PhD, and JAMA Senior Editor Derek C. Angus, MD, MPH:
#PragmaticTrials are intended to support real-world clinical decision-making, but the term is used inconsistently across studies. A pragmatic orientation may improve the applicability of
#ClinicalTrials to routine care, yet it does not justify weaker methods or reduced rigor.
📣 This September’s JAMA+ Trials Theme of the Month examines ongoing confusion and debate in pragmatic trial research, including how eligibility, intervention delivery, outcome assessment, and analysis align with pragmatic goals. Clearer design and reporting may help clinicians and health systems judge whether trial findings are usable in practice.
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