HELP US DECIDE ON OUR NEXT PODCAST An upcoming episode of ATRM Classic will be a deep dive into one of the below. Vote for your favourite, and please repost 😃

Wait. Peggy Olsen’s sister eventually moved to Utah and started a new family?

Scientists Discover New Compound That Burns Fat Without Killing Your Appetite | University of California Berkeley Unlike GLP-1 drugs, which suppress appetite and reduce energy intake, a newly identified molecular compound helps cells burn more energy without changing food intake or exercise and has shown promise in mouse models. The most successful new obesity drugs largely work by helping people eat less. Researchers at UC Berkeley are exploring a different strategy: increasing how much energy the body uses, rather than reducing how much energy comes in. Over the past five years, GLP-1 medications such as Ozempic, Wegovy, Mounjaro, and Zepbound have transformed treatment for obesity, diabetes, and fatty liver diseases by helping people lose weight and control blood sugar. But some patients experience nausea and other gastrointestinal problems, and because the drugs suppress appetite and reduce food intake, they can also contribute to nutritional deficiencies and loss of muscle, potentially increasing frailty and other long-term health problems. The Berkeley researchers identified a potential treatment for obesity and diabetes that instead raises energy expenditure, effectively increasing the body’s metabolic rate. In a study published in Science Advances, they investigated 5-tetradecyloxy-2-furoic acid (TOFA), a molecular compound that both suppresses production of lipids such as cholesterol and triglycerides and activates genes that help cells burn fat and produce energy. In mice, TOFA improved insulin sensitivity and glucose control, reduced triglycerides, and improved features of fatty liver disease. Obese mice treated with the compound lost fat without a significant reduction in lean muscle mass. “Body weight responds to two levers: taking in fewer calories, or spending more energy,” said Anders Näär, a professor of metabolic biology and nutrition at UC Berkeley and senior author of the study. “GLP-1s work almost entirely on the first, so we went after the second.” TOFA boosts energy use without raising triglycerides TOFA was originally discovered in the 1970s and belongs to a group of compounds called ACC inhibitors, which interfere with lipid production in the body. Several ACC inhibitors have advanced to mid-stage clinical trials, but none has been approved for metabolic disease, in large part because many can increase triglyceride levels and potentially raise cardiovascular risk. The researchers found that TOFA behaves differently. In addition to inhibiting ACC, it activates PPARα and PPARδ, cellular receptors that switch on genes involved in taking up fat and burning it for energy. In mice, this increased energy expenditure by as much as 18% without changes in physical activity or body temperature. TOFA also avoided the rise in triglycerides seen with other ACC inhibitors, possibly because of this dual action. “TOFA appears to engage a coordinated metabolic response,” said study first author Justin Y. Lee, a postdoctoral student at UCSF who conducted the research as a Ph.D. student at Berkeley. “It is not simply blocking lipid synthesis. It is also activating energy expenditure pathways that may help the body handle excess lipid and glucose more effectively.” To test whether the two effects could simply be reproduced separately, the researchers gave mice one compound that blocked lipid production and another that increased energy expenditure. That combination did not improve overall metabolic health as effectively as TOFA alone. TOFA strengthened GLP-1 effects in mice The researchers also tested TOFA alongside GLP-1 medications, including semaglutide, sold as Ozempic and Wegovy, and tirzepatide, sold as Mounjaro and Zepbound. In mice, combining TOFA with these drugs produced greater improvements in body weight, glucose control, insulin levels, and triglycerides than either treatment used by itself. “In our combination experiments, TOFA worked additively or synergistically with the GLP-1 appetite-suppressing drugs, so we view it as complementary rather than as a replacement,” Näär said. TOFA has so far been studied only in animals, and researchers caution that its safety and effectiveness in people remain unknown. With support from Berkeley’s life sciences entrepreneurship ecosystem, including Nucleate and Berkeley SkyDeck, the researchers founded ReRx Therapeutics to pursue further development of the approach. Read more: scitechdaily.com/scientists-…

You guys don't have to pay attention to the things I say. You can ignore me. But I think it's fairly boring that everyone says exactly the same thing and everything is fandom and PR. I think some people crave something that is not that. At least I can provide something else.

“In what reality”???????!! News Flash: THIS WAS NOT REAL!! What a bunch of fucking morons these hacks are! 😂🤦‍♂️🤮

I couldn’t finish’s the ridiculous The Alto Knights on Hulu! hulu.com/movie/bd9f5a44-4e61…

I donated my Rickenbacker 370-12 guitar and the yellow jacket I wore on the BYRDS "Mr. Tambourine Man" album cover to Marty Stuart's Congress of Country Music in Philadelphia MS: facebook.com/share/r/1FgkLNz… congressofcountrymusic.org/

56 years ago I was getting ready for Organic, Organic Lab, Physics, Physics Lab, Biology, Biology Lab and Sociology 18 credits.

The people and interests and fake left senators (BS of VT etc) who "saved" you from COVID in history's bang-for-the-buckest global power play are out to "save" you from AI now and nothing, nothing should terrify you more -- in part because they control those very AIs. Once secure at their wheels with bureaucratic help, once flying the banner of safety atop their ships, once fully intoxicated on their own virtue as altruistic knights from Planet NICE, they will use the machines they say everyone else should fear in ways that only human zealots can. Fear not the weapons themselves. Fear the hands that hold them, point them.

I just can't stop thinking about those poor babies, strangled by their own mother. What a horrific story, as is the reaction of so many people to it. Gail seems more discomfited by the fact the holdout was a black man than the murder of the innocents.

A lot of doctors are still diagnosing lateral hip pain as trochanteric bursitis, but more often than not, there’s no actual bursitis. The problem is more likely gluteal tendinopathy. That is why throwing anti-inflammatory medications at the problem rarely solves it. The best way to fix this issue is a slow, progressive load based rehab program targeting the gluteus medius and minimus tendons. This helps to stimulate tendon remodeling and improve functional strength.

Penske media and all trades need writers with balls as big as @JosephKahn. Love this. hollywoodreporter.com/movies…

For anyone interested in what happened to Nike.

“The San Gabriel Vally was this deus ex machina. The people who flocked there flocked there for unconscious reasons that superseded the conscious application of logic and made anything possible” -James Ellroy

"The NFL Today" Pregame Show September 2, 1979 The first Sunday of the NFL's 60th season kicks off with the league's preeminent studio show, featuring CBS Sports' Brent Musburger, Jayne Kennedy, Irv Cross, and Jimmy "The Greek". As start times for the early games were still staggered in that era, some games are already in-progress. • Brent recaps the previous night's contest between the Buccaneers and Lions • A "Remote Reports" stadium whip-around segment follows, with color analysts Tom Brookshier, Paul Hornung, and Johnny Morris • Jayne has a feature on the Dallas Cowboys' Ed "Too Tall" Jones, who had (temporarily) retired to pursue a boxing career • Irv covers the recent blockbuster Oilers-Patriots trade involving All-Pro tackle Leon Gray • "The Greek" makes his picks for the day's games and offers his prognostications for the upcoming season

You guys have absolutely NO idea what the hell you are talking about on this story!! None!

WNBA black athletes think calling themselves “young hoes” is a badge of honor.

She will be so missed. A total treasure. 🌸💗🌸💗🌸🙏

A message from the family of Dolly Parton.

McCartney perfected the process of distilling Abbey Road’s medley into one song on Band on the Run’s title track, but The Back Seat of My Car is a more than commendable first attempt. (Even if Lennon did it first on Happiness Is a Warm Gun.) But whereas Band on the Run is more of a seamless flow, here Macca juggles many musical ideas back and forth, with the overstuffing part of the charm of this cracking wee mini-medley. It’s a fittingly exuberant way to bring this fantastic album to a rousing finale. piped.video/yK-FnCnBbUI?is=XKcx…