Cancer drugs that appear effective in lab tests do not always perform the same way in the body, complicating the search for effective osteosarcoma treatments. To better reproduce the tumor environment during preclinical testing, researchers developed a practical 3D osteosarcoma model using alginate microfibers, some containing a bone-like mineral. Over 21 days, cells remained viable and metabolically active while forming tissue-like aggregates and extracellular matrix components. When exposed to doxorubicin, cells grown in the 3D model showed up to sixfold greater resistance than those in conventional 2D cultures. More realistic modeling of osteosarcoma drug response could improve how potential therapies are screened and prioritized, providing stronger evidence for decisions about which should advance in development. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Evaluation of a Simple 3D Bioengineered Model: A Step Closer to Bridging the In Vitro–In Vivo Gap in Osteosarcoma Research 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Jelena Petrovic, Ivana Banicevic, Luka Bojic, Milena Milivojevic, Radmila Jankovic, Bojana Obradovic, and Jasmina Stojkovska @Univerzitet_BG @IMGGE @UBmedicinski 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

People who rely on heart pumps need devices that can adapt to changing activity levels while using less power. Researchers addressed this by developing a real-time control algorithm that automatically adjusts left ventricular assist device (LVAD) speed based on the energy used to maintain magnetic levitation. They tested the algorithm in a previously validated numerical mock circulatory loop coupled with a detailed LVAD model. In simulations, the controller increased circulatory support during exercise while allowing lower pump speeds during sleep without compromising hemodynamic output. Reducing power use while adapting support to changing demands could help make wireless charging practical – paving the way for devices that lower infection risk and respond more naturally to everyday life. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Automatic Speed Modulation Based on Real-Time Cardiac Activity Monitoring for a Next-Generation LVAD 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Phong Hoang Tran, Nobuyuki Kurita, Chris Hoi Houng Chan, O. H. Frazier, Yaxin Wang, and Joseph Cavallaro @RiceUniversity @RiceEngineering @RiceECE @BCMHouston @Texas_Heart @BCM_Surgery 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Changes in how the brain regulates blood flow and oxygen may contribute to cognitive decline, but detecting these vascular abnormalities at an early stage remains difficult. Taking aim at this problem, researchers compared how the brain responded to shifts in oxygen and carbon dioxide in healthy adults and those with mild cognitive impairment. Participants underwent controlled changes in inhaled oxygen and carbon dioxide while cerebral oxygenation, blood pressure, and other physiological signals were measured and dynamic modeling was used to characterize their responses. Compared with healthy controls, the mild cognitive impairment group showed altered blood pressure and carbon dioxide responses consistent with impaired vascular and reflex control and possible disruption of neurovascular coupling. The physiological differences identified in this study could inform biomarkers for detecting cerebrovascular dysfunction sooner, helping identify individuals who may benefit from closer monitoring or targeted strategies to preserve cognitive function. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: PRBS Gas Challenges Reveal Impaired Chemoreflex and Cholinergic Dynamics in MCI 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Suhaib Hashem, Stanley Yamashiro, Elizabeth Joe, Helena Chui, and Vasilis Marmarelis @USC @USCViterbi @USCBME @KeckSchool_USC 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

In some diseases, cells can undergo harmful changes in their structure and behavior, raising the question of whether those changes can be controlled without directly altering what happens inside the cell. Against this backdrop, engineers reviewed how interactions with the surrounding extracellular matrix could help regulate cell behavior. They traced how physical signals travel from adhesion sites through the cytoplasm to the nucleus, where they can shape biological processes. The authors also discussed how manipulating this mechanical environment could help control endothelial-to-mesenchymal and epithelial-to-mesenchymal transitions, as well as related reprogramming and differentiation processes. Bringing these mechanisms together could guide the development of therapeutic strategies that harness the cellular environment rather than directly targeting intracellular processes. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗥𝗲𝘃𝗶𝗲𝘄: Mechanical Signaling From ECMs to Nuclear Envelopes in Cell Transitions and Fate Decisions: A Review and Perspective on Adhesion-Niche-Based Anti-EndMT and Anti-EMT 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Jichul Kim, Hayeong Jang, Ye Eun Song, and Soo-Hong Lee 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Brain–computer interfaces can translate imagined movements into actions, but their algorithms still struggle to accurately decode different movements of the same limb. Researchers reviewed five years of work on using electroencephalography (EEG) to classify imagined upper-limb movements and identify opportunities to improve decoding. They compared state-of-the-art classification methods, their performance, and underlying assumptions while examining persistent challenges – including low signal-to-noise ratios, non-stationary signals, and difficulty distinguishing finer motions. They also assessed emerging trends and the opportunities and limitations associated with translating these approaches into real-world applications. Understanding where current methods show promise and where improvement is needed could help advance systems capable of translating increasingly specific movement intentions into more precise control of real-world technologies. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗥𝗲𝘃𝗶𝗲𝘄: Decoding Upper-Limb Motor Imagery from EEG Signals: A Systematic Review of Methods and Applications 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Zhendong Su, Kok Beng Gan, and Kok Swee Sim @ukm_my @mmumalaysia 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

In heart failure, changes within the myocardium – the heart muscle – can disrupt oxygen delivery to cells, potentially contributing to further cardiac dysfunction and disease progression. Exploring this disruption, researchers developed a histology-image-based computational model to investigate how enlargement of the space between cardiac cells and reactive interstitial fibrosis affect oxygen delivery from capillaries. Their analysis found that both structural remodeling and fibrosis-related changes in tissue properties impaired oxygenation, with levels in heart muscle cells approximately 47% lower in severe fibrosis than in normal tissue. The balance between capillary area and interstitial area strongly predicted oxygenation, reflecting the combined effects of available supply and the distance oxygen must travel through tissue. Linking measurable structural features with cellular oxygen levels could ultimately help identify when impaired oxygenation may be contributing to worsening heart function, informing future approaches to heart failure treatment. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Oxygen Transport Impairment in the Failing Heart: A Histology-Image-Based Computational Analysis 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Haifeng Wang, Mythri Tumbalam Gooty, @dlanfearMD, Hani N. Sabbah, and Lik-Chuan Lee @michiganstateu @MSU_EGR @HenryFordHealth 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Treating obstructive sleep apnea with mandibular advancement devices depends on keeping the lower jaw sufficiently forward to support an open upper airway throughout sleep. Researchers examined how the design of these devices affects their ability to maintain lower jaw positioning as the mouth opens. Using validated mathematical models, they simulated jaw movement with seven widely used devices across 21 individuals and found that: 🔹 Bar-based devices generally maintained advancement more effectively than fin-based designs, although performance varied with bar length, joint position, and facial morphology. 🔹 Shorter bars and more forward-positioned joints produced greater protrusion, while devices with fins consistently allowed the jaw to move backward during mouth opening. These findings could inform more personalized device selection and design, helping clinicians tailor oral appliance therapy to an individual’s craniofacial anatomy and mandibular movement. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Performance of Mandibular Advancement Devices When Opening the Mouth 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Juan A. Cabrera, Alex Bataller, Pedro Mayoral, and Javier Pérez @infoUMA @IndustrialesUMA @UCAM 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Compression therapy is widely used for swelling, circulation problems, and ligament injuries, creating a need for devices that can serve diverse therapeutic applications. Engineers reviewed 86 studies examining chronic venous insufficiency, edema, ligament injury, and theoretical models of compression to identify shared biomechanical principles that could guide device development. Across these conditions, compression was found to reduce transmural pressure, increase interstitial pressure, and increase joint stiffness, while theoretical models showed how it regulates tissue geometry, fluid balance, and stiffness. Therapeutic effects also depended on how pressure was applied – including static or dynamic operation, distribution and level, and location. This synthesis could inform the design of compression devices that more deliberately control tissue mechanics and fluid behavior to achieve the intended therapeutic effect. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗥𝗲𝘃𝗶𝗲𝘄: Compression Therapy in Human Body Applications: A Systematic Review from Principles to Practice 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Pengfei Han, Malte Asseln, Gabrielle Tuijthof, and Izadyar Tamadon @UTwente 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Blood pumps can sustain circulation in people with severe heart disease, but current testing of these devices may not adequately capture factors associated with persistent bleeding and clotting risks. To examine one important part of this problem, researchers conducted a review of 39 studies assessing platelet function in mechanical circulatory support devices. Experimental approaches varied substantially in duration, loop design, pump type, and anticoagulation, while flow cytometry emerged as the predominant method for directly evaluating changes in platelet state. The authors point to a need for standardized protocols and complementary biomarkers that can better characterize how device-generated forces alter platelet function. Deeper insight into the strengths and limitations of blood pump testing methods could inform design improvements that minimize harmful changes in platelet function, potentially reducing bleeding and clotting complications during mechanical circulatory support. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗥𝗲𝘃𝗶𝗲𝘄: Hemocompatibility of Mechanical Circulatory Support Devices: An Integrated Review of Platelet Function Assessment in In-Vitro Blood Experiments 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Xiangyu He, Michael B. Fischer, Daniel Zimpfer, Alice Assinger, and Marcus Granegger @MedUni_Wien @LBG_research 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Repairing large bone defects with 3D scaffolds depends on keeping cells alive throughout the structure – a challenge when oxygen cannot reach its deepest regions. To address this limitation, researchers tested whether flowing fluid through porous silk fibroin scaffolds with hollow channels could improve oxygen delivery and support bone formation. Scaffolds with 0.5- or 1-millimeter channels provided more even oxygen delivery and cell distribution, while combining the channels with fluid flow increased cell numbers, collagen production, and mineralization. Adding channels reduced compressive strength but did not alter the scaffolds’ porous structure, degradation rate, or stiffness, and modeling showed that they remained mechanically resilient under the tested strain. More effective tissue formation within larger engineered grafts could ultimately expand reconstructive options for bone defects that currently require complex surgical repair, providing a path toward more viable regenerative approaches. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Perfusion Cell Culture Induces Oxygen Diffusion and Osteogenic Activity in Multi-Channeled Critical-Size Silk Fibroin Scaffolds with Pre-Osteoblasts: Experimental and Finite Element Modeling Study @UvA_Amsterdam @VUamsterdam @ut_newsline 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Facemask impacts are a major source of head injury in American football, yet helmet protection has largely focused on the shell rather than the chinstrap system. Researchers examined whether different designs could influence the severity of these collisions by testing 14 chinstraps on an identical helmet at two velocities. Chinstrap model significantly affected the Head Acceleration Response Metric, with differences between models reaching 35.4% at 3.0 m/s and 31.4% at 7.4 m/s. Thicker chin cup liners and longer bottom straps were associated with lower injury risk metrics at the lower velocity, although these relationships were not observed at the higher velocity. Incorporating chinstrap characteristics into future helmet testing and design could broaden how protective equipment is engineered to manage forces transmitted to the head during play, opening another avenue for reducing football-related brain injury risk. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Chinstraps Influence Head Impact Severity in Laboratory Facemask Impacts 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: @nick_cecchi, Kyle J. Casazza, and David B. Camarillo @SoftShox 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/article/10…

Rotator cuff tears can place excessive stress on surrounding tendons, potentially contributing to further tissue damage and treatment failure. Examining how these forces are distributed across the shoulder, researchers tested whether coordinated loading across multiple rotator cuff muscles could reduce concentrated strain around U-shaped supraspinatus tears. They measured tendon deformation in eight cadaveric shoulders while the supraspinatus was loaded alone and while the supraspinatus, infraspinatus, and subscapularis were loaded together. Coordinated loading reduced strain concentration in the superior infraspinatus and produced more balanced force transmission across the posterior rotator cuff. By accounting for how coordinated rotator cuff muscle forces influence regional tendon strain, this study supports the development of surgical repair and rehabilitation strategies that could better protect vulnerable tissue, promote healing, and reduce the risk of recurrent injury. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Inter-Rotator Cuff Muscle Force Sharing Mitigates Superior Posterior Cuff Tendon Strain in U-Shaped Supraspinatus Tears 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Kyosuke Hoshikawa and Hugo Giambini @UTSA @utsa_ceid @BmeUtsa @GiambiniL 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

People with severe mitral valve disease need replacement valves that open effectively while withstanding repeated mechanical stress, making device durability critical to long-term outcomes. To explore how engineering choices affect this balance, researchers examined the biomechanical performance of bileaflet transcatheter mitral valves. Using finite element simulations, they compared five leaflet material models paired with cobalt chromium or nitinol stents across three cell densities under physiological pressure loading. Leaflet material model had the greatest influence on opening and leaflet stress, while stent composition primarily affected stress within the frame and increasing cell density improved stress distribution with only a modest reduction in opening. Better-informed choices about leaflet properties and stent architecture could help reduce mechanical factors associated with valve deterioration, potentially extending the lifespan of transcatheter replacements. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Comparative Analysis of Leaflet Materials, Stent Materials, and Stent Cell Density for Bileaflet Transcatheter Mitral Valve Design 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Joseph Chibuike Nwokeafor, Joshua D. Hofmeister, Breandan B. Yeats, @LPDasi, @ChetRihal, @JuanCrestanello, Leigh Griffiths, @adnanalkhouli, and @DrHodaHatoum @michigantech @mtu_engineering @mtu_computing @GeorgiaTech @gatechengineers @EmoryUniversity @EmoryMedicine @CoulterBME @MayoClinic @MayoClinicCV 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Reduced blood flow to the heart can progress to a heart attack, increasing the need for reliable ways to detect it without invasive testing. Researchers conducted a literature review of computational approaches designed to improve the noninvasive assessment of myocardial ischemia through fractional flow reserve (FFRCT) and instantaneous wave-free ratio (iFRCT). The authors note that current computational fluid dynamics models can oversimplify how artery walls and different types of plaque affect resistance at narrowed sections of coronary arteries, while failing to fully account for compensatory changes in coronary microcirculation – factors that can reduce diagnostic accuracy. They also evaluated strategies for improving physiological fidelity and computational efficiency, including the integration of multimodal clinical data, AI, and digital twin technology. Defining where current models fall short and where innovation is most needed can guide the development of more effective tools for detecting dangerous cardiovascular changes before they cause lasting heart damage. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗥𝗲𝘃𝗶𝗲𝘄: Non-Invasive Computational Techniques for Diagnosing Myocardial Ischemia: Challenges and Future of FFRCT/iFRCT 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Bao Li, Jincheng Liu, Yang Yang, Hao Sun, Chi Zhu, Leo Hwa Liang, Zijie Wang, Luyao Fan, Suqin Huang, Xueke Li, Guangfei Li, Liyuan Zhang, Yanping Zhang, Jinping Dong, Boyan Mao, Chang Hou, Jian Liu, Wenchang Tan, and Youjun Liu @PKU1898 @NUSingapore @nus_cde_sg 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Strong bones take shape as the skeleton adapts to movement and weight-bearing, but how this process unfolds early in life remains unclear. A systematic review of 25 human and animal studies examined trabecular bone development from birth through the early juvenile period, finding evidence for a two-stage process resembling pruning in other biological systems. In humans and other altricial mammals, an initial excess of trabecular bone appears to be selectively reduced around the onset of independent movement, particularly in weight-bearing long bones. The remaining architecture then becomes more directionally organized and structurally refined, suggesting that mechanical loading may help determine which trabeculae are retained as the skeleton matures. This developmental sculpting process could reshape how researchers identify the mechanical and biological factors that build skeletal strength – and how disruptions early in life may influence bone health for years to come. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗥𝗲𝘃𝗶𝗲𝘄: Too Many Bones to Pick – from Overproduction to Refinement: Evidence for Trabecular Pruning in Early Postnatal Development as a Distinct Phase of Skeletal Functional Adaptation 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Meir M. Barak, Anmol Madaan, Jack Nguyen, and Sarah Borgel Francis @longislandu @UofSC @PalmettoCollege @USCLancaster 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Excessive joint loading can contribute to orthopedic problems, raising an important question about faster walking: Can people pick up the pace without placing unnecessary forces on their lower limbs? To examine how walking patterns affect these forces, researchers compared the effects of increasing step length versus step frequency on the hip, knee, and ankle at a faster pace. Twelve healthy young adults completed a preferred-speed condition and two higher-speed conditions, while motion data, ground reaction forces, and musculoskeletal modeling were used to estimate contact forces. Longer steps produced greater loads across much of the lower limb, while higher step frequency generally tempered these effects and reduced several measures of cumulative loading. Clarifying how walking patterns influence joint stress could inform practical approaches to managing pain, rehabilitation after injury or surgery, and preserving mobility over time. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Independent Influences of Increased Step Length and Step Frequency on Lower-Limb Joint Loading During Fast Walking 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Momoko Yamagata, Hiroshige Tateuchi, Kiseki Okumura, and Noriaki Ichihashi @kmu1928 @KyotoU_News @univkyoto 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Neck injuries can damage the structures that stabilize the spine, creating a need for testing methods that accurately replicate how the neck responds to forces from multiple directions. Researchers developed a low-cost, moldable cervical spine surrogate to provide a more practical way to reproduce the neck’s response to multidirectional loading in physical testing. Using topology optimization guided by a validated GHBMC virtual human body model, they created an anatomically inspired, single-piece resin design and fabricated it using a custom mold. Robotic testing showed that the surrogate reproduced key aspects of the model’s mechanical behavior across flexion, extension, and lateral bending. This work could provide a more accessible physical platform for studying cervical spine mechanics, testing protective systems, and refining injury mitigation strategies that ultimately reduce the risk and severity of neck injuries. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Design and Validation of a Stiffness-Matched Cervical Spine Surrogate 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Katie R. G. Zilevicius, Mary Kathryn Hederick, B. Wade von Kleeck, Emma C. Coltoff, Tyler J. Roy, Jed C. Wilbur, Brian S. Graybill, @ScottGayzik, and Philip J. Brown @WakeForest @wakeforestmed @wakeforestbme 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

When tissues receive too little oxygen, their function can be impaired, but understanding these effects requires lab models that accurately recreate how oxygen levels change in the body. Addressing this experimental gap, researchers developed and validated a mathematical model that predicts oxygen levels in a standard hypoxia chamber while accounting for oxygen used by endothelial cells. They then combined the model with an optimization method to create a gas controller protocol that reproduced the oxygen levels and fluctuations predicted for an individual with obstructive sleep apnea at the cell layer. The analysis also identified the height of the cell culture media, evaporation, and location within the chamber as important factors in study design. Using mathematical modeling to recreate clinically observed conditions in the lab could strengthen the connection between human data and experimental research, supporting more relevant disease studies and the development of more effective treatments. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: A Modeling Approach to Inform In Vitro Hypoxia Platforms for Patient-Specific Analyses 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Nida T. Qayyum, Andrew T. Cole, @Pim_Oomen, Rami N. Khayat, and Anna Grosberg @UCIrvine @UCIEngineering @cbeuci1 @CCBS_UCI @UCIMedSchool @UCI_CMCF @UciStemCell @penn_state @PennStHershey 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

After a stroke, walking problems can vary widely from one person to another, with different movement patterns affecting the ability to push the body forward and maintain walking speed. Researchers examined which gait characteristics were most closely tied to this loss of walking performance by analyzing 3D gait data from 77 community-dwelling individuals with stroke and 101 healthy volunteers. Four features involving the paretic shank, knee, and ankle, as well as the non-paretic knee, were associated with paretic propulsion overall, but their importance differed by gait pattern. Among those with higher gait function, propulsion was associated primarily with paretic shank and ankle mechanics, whereas lower-functioning walkers showed stronger associations with asymmetrical hip extension and non-paretic knee extension. Recognizing these distinct biomechanical profiles could help clinicians tailor rehabilitation to the movement patterns most relevant to each individual, supporting more targeted strategies to improve walking ability after stroke. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Identification of Gait Patterns Associated with Paretic Propulsion and Velocity in Community-Dwelling Individuals with Stroke: A Multicenter Retrospective Study 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Naoto Mano, Kimihiko Mori, Takayuki Kuwabara, Yuta Chujo, Masanori Wakida, Tomohiro Ushikubo, and Kimitaka Hase @kmu1928 @Anima__Corp 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…