Biochemist | Synthetic Biologist | Inventor | Entrepreneur
Saint Louis, MO
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- Following 1,547
- Followers 1,541
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Khalid K. Alam • خالد كمال عالم retweeted
As frontier models get nerfed for bio tasks, being able to run locally is increasingly important.
Run Qwen 3.8 Flash-Next at up to 400k context and peak single-stream output of 180.5 tok/s on an RTX PRO 6000 Max-Q.
This is now my daily workhorse. See below 👇
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Khalid K. Alam • خالد كمال عالم retweeted
Anthropic's discovery of array-associated reverse transcriptases?
Turns out it was already done by a Danish scientist. He used Claude for administrative tasks, but not in an agentic manner for the discovery. He already filed a patent and gave talks on it
nytimes.com/2026/09/27/scien…
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Khalid K. Alam • خالد كمال عالم retweeted
Artificial intelligence systems do not think, feel, want or understand. Avoid language that gives them human characteristics. This is called anthropomorphizing, when we ascribe human traits, emotions or behaviors to non-human things, such as animals or inanimate objects.
Instead, explain what a system does, how well it performs, who built it and who could be affected by it.
apnews.com/article/openai-sa…
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Who is working on open source AI for life sciences?
How do models like Qwen3.8, GLM-5.3, DeepSeek v4, etc. perform on life science workflows?
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Anthropic should hire wet lab biologists to LEAD their life sci efforts w/ computational biologists providing a critical support role, until they (the comp bios) are displaced by AI.
Wet lab data (and overzealous "safety" guardrails) are the bottleneck, not compute.
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I'd love to hear @zhangf's thoughts on this work. The press release seems to swag jack his status but the quote itself is revealing, "genuinely intriguing and merits further investigation."
If I had a dollar for everything that was intriguing...
Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR.
We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use.
Read more: anthropic.com/news/claude-di…
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Asking Claude about this paper will put you in time out (demoted from Opus 5.5 to 5.0)
Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR.
We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use.
Read more: anthropic.com/news/claude-di…
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Maybe I'm missing something, but this seems like a giant nothing burger 🤷🏾♂️
Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR.
We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use.
Read more: anthropic.com/news/claude-di…
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Investigating stability of a nucleic acid triggered a flag and demotion from Opus 5.5 to 5. There's very clearly a lack of bio-expertise at Anthropic / Claude and a preponderance of doomers.
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Khalid K. Alam • خالد كمال عالم retweeted
Her name is HIND RAJAB💐🌷
🤞🏾🪶♾❤️
And She was more brave than every single one of you at ESPN
Kyrie Irving has offered to pay Houston Texans linebacker Azeez Al-Shaair's $11,941 fine for having the name of a Palestinian girl killed in Gaza written on his eye black during Sunday's game against the Buffalo Bills. spr.ly/6012BGpQce
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Khalid K. Alam • خالد كمال عالم retweeted
The absolute cowardice of @edsheeran.
History will remember
Macklemore Speaks Out After Being Dropped From Ed Sheeran Tour, Says Singer Claimed That Saying 'Free Palestine' Was 'Hurtful to a Lot of People' variety.com/2026/music/news/…
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11/10 racist Islamophobic divisive hateful trash
A group connected to Texas U.S. Sen. Ted Cruz is now getting involved in TV advertising in Michigan's U.S. Senate race, airing this AI-generated spot today in Detroit: piped.video/Lrw_hLs4O_0?si=Q_XQ…
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Khalid K. Alam • خالد كمال عالم retweeted
I picked up a carton of milk from the store this week that had H5N1 influenza in it.
>150 million copies/liter!
Thankfully, it was safe to drink because the milk was pasteurized, so I’m not saying what brand.
Takehome: DON’T DRINK RAW MILK.
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Khalid K. Alam • خالد كمال عالم retweeted
My lexical call-to-arms is now out in The Atlantic: Let’s abandon the term “lab” as a term for the AI industry’s most powerful corporations. We should reserve the word for organizations whose primary activity is scientific research. Gift link: theatlantic.com/technology/2…
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Khalid K. Alam • خالد كمال عالم retweeted
Let me say what too many seem scared to:
America is stronger because the best and brightest from around the world come here and build here.
They fuel innovation, which creates more jobs for Americans.
And the world benefits from what we all build together.
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Khalid K. Alam • خالد كمال عالم retweeted
Sounds like some VC investments…
“We paid a lot of money, but the situation only got worse.”
NEW: Israel funded a fake US think tank called the "Hanover Institute" that published 124 reports totaling over 560,000 words in nine days, designed to be cited by AI chatbots like ChatGPT, Claude, and Perplexity.
The site was built on a platform that promises to optimize content so AI systems will treat it as credible research.
Every headline mirrors a question a user might type into a chatbot:
Is Israel Carrying Out a Genocide in Gaza?
The answers consistently frame information to blunt criticism of Israel.
The operation was funded through Israel's government advertising agency via the European ad group Havas, with tens of millions of dollars routed to American contractors including a firm run by former Trump campaign manager Brad Parscale.
An Israeli official admitted to Ynet:
We paid a lot of money, but the situation only got worse.
Source: The Guardian
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Khalid K. Alam • خالد كمال عالم retweeted
One of the world's most brutal murderers is finally dead.
At 84 years old the former Bosnian Serb general, Ratko Mladić lived way longer than he allowed his tens of thousands of victims.
The more than 7000 Muslim men and boys he had slaughtered in Srebrenica will be his enduring shame.
At least he was tried by an International Criminal Tribunal and found guilty of his enormous crimes of genocide.
I am proud of the work we journalists did in the 90s to document his crimes against humanity, to finally hold him accountable.
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Kids in Gaza are literally forced to destroy their kites after Israel threatened anyone flying a kite with death. No one from the IDF is coming out and saying “don’t worry children, of course we won’t bomb you”. Is it really that hard for Israel to refrain from bombing children? @rabois is this really your definition of morality?
🔸 Palestinian boy destroys his kites, fearing they’ll bring Israeli bombs
Muhammad Ahmad al-Mufti, a boy in Gaza whose father was earlier killed by Israeli forces while seeking aid, tore apart the paper kites he had made himself, after hearing Israeli Defense Minister Katz might strike over the kites, Gaza Relief Committee’s Eyad Amawi told Drop Site.
Furious and in tears, he mocked the Israeli leaders he blamed as he destroyed them. “So that Netanyahu is satisfied,” he said. “So that Katz is satisfied. So that Trump is satisfied.”
Minister Katz threatened a “forceful” response to Palestinian kites landing in areas across the border, and said Israel would treat them the same as drones.
“They want to deprive us of the thing we love,” al-Mufti said, breaking down. “I swear my heart is breaking.”
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Khalid K. Alam • خالد كمال عالم retweeted
Our new paper in PNAS reports the presence of Na+ and Li+ #aptamer RNAs in mammals. The latter hints at natural roles for #lithium in humans and provides direct links to #BipolarDisorder. Now seeking funding to study Li+ biology and create new therapeutics.
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