Assistant Professor @MountSinaiPsych ▪Brain+Body interactions in stress/fear/metabolism Lab ▪Yogā▪ "Somewhere, something incredible is waiting to be known"🧠🌌
I want to share this research was inspired by me-search: everyday yoga practice that involves breathing and meditation and contemplation to know more biologically!
Excited to share new work from our lab showing, for the first time, a link between breathing dysregulation, stress responses, and energy metabolism via a neuropeptide receptor mechanism.
This opens new ways for understanding brain–body interactions! biorxiv.org/content/10.64898…
#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics#neuroscience#BrainAtlas
How regular exercise enhances our immune response.
A multiomic blood assessment (single-cell RNA, epigenetics, metabolites, lipids, and cells) with distinct signature for exercise vs sedentary lifestyle @ScienceAdvancesscience.org/doi/10.1126/scia…
Postdoc job alert! I’m looking for someone with a PhD in neuroscience/psychology, psychiatry, computational modeling or a related field to join my NIH-funded team at UCLA studying the neural & computational mechanisms of #interoception in anorexia nervosa 1/2
You emit light.
Expanding biology beyond molecules allows us to consider another layer of life: how energy, including light, may reflect and perhaps help coordinate biological activity.
Thank you to @JoMarchant and @Nature for featuring our work alongside other leaders in the field, and for opening a broader conversation about what might be possible, the tools we must build, and the next generation of scientists we must train.
Now, we have the opportunity to determine what the light of life is telling us.
ATP-sensitive potassium channels function as sensors linking mitochondrial state to accumbal circuit output and effort-related behavior
nature.com/articles/s41386-0…"
Exercise helps improve depression and anxiety. With the Ben Greenwood lab, we wondered if irisin can help improve depression and anxiety in a rodent model. Yes, it looks promising. Feel free to check our preprint.
biorxiv.org/content/10.64898…
The hidden logic of emotion and anxiety. How does the brain turn a racing heartbeat into an inference of threat or safety?
A fascinating new perspective in Science explores "internal emotion models"—neural circuits that integrate lingering emotional states, bodily (interoceptive) signals, and prior learning to map abstract context and infer meaning.
By bridging the gap between reactive animal behavior and higher-order human experience, this cross-species framework is unlocking fresh mechanism-based pathways for treating anxiety and trauma.
#Neuroscience#Neurobiology#PredictiveProcessing#Interoception#MentalHealth#BehavioralScience#ScienceJournal#Biology#CrossSpeciesscience.org/doi/10.1126/scie…
What determines whether a cell lives or dies? This Review argues that metabolism is the ultimate gatekeeper. Energy status, mitochondrial function, redox balance, and lipid metabolism dictate how regulated cell death unfolds, offering new targets for treating cancer and degenerative diseases. #Immunometabolism#CellBiologycell.com/cell-metabolism/ful…
Still taking this in. It's been a long road, and I'm deeply grateful to my mentors, lab mates, friends, and family who have been part of this journey. Thank you to @NIH_NINDS for the opportunity to join the #DSPAN Scholar community. Excited for this next chapter!
✨HUGE CONGRATULATIONS @GylesTrevonn on being awarded an @NIH Blueprint & BRAIN Initiative F99/K00 award! This two-phase grant helps outstanding neuroscience graduate students complete their dissertations & seamlessly transition into postdoctoral research positions. @EricJNestler
EXCITING PAPER! In this review, Drs. @jainparul321 & Daniela Schiller synthesize research across various domains to trace how relationships develop from initial impressions through repeated interactions to stable social bonds & networks. @NeuroCellPress 👉
cell.com/neuron/abstract/S08…
🧠🏃 New preprint exercise neuroscience from the lab!
We built a multi-organ spatial metabolomic atlas of long-term exercise in mice. Six organs. 224 metabolic features. Coordinated inter-organ remodeling.
The biggest surprise? The brain reshaped its metabolism the most, region by region.
We took the same approach into PS19 tau mice. Exercise cut over 70% of observable tau pathology in the hippocampus and restored the mitochondrial metabolome.
Integrated proteomics + spatial metabolomics pointed to one convergent node: NADH dehydrogenase Complex I.
So we tested it. We expressed yeast Ndi1 in PS19 neurons. No exercise. This alone raised brain antioxidants, restored shuttle metabolites, and reduced tau pathology.
Boosting Complex I activity reproduces the core anti-tau effects of exercise. A molecular handle on why movement may protect the aging brain.
biorxiv.org/content/10.64898…