Sneh Koul and Dr. W. Lee Kraus, together with their @UTSWMedCenter team offer mechanistic insights into subtype-specific gene regulation and potential determinants of PARP inhibitor sensitivity in #BreastCancer. 💊 | @MCR_AACR
🔗 Abstract: bit.ly/3RAXHqO
"I loved math when I was growing up. Nobody in my family was a scientist, but my father loved doing puzzles. So we did a lot of puzzles."
Read about how chemistry laureate Jennifer Doudna's scientific journey started: bit.ly/2M82Chu
ALT Jennifer Doudna smiling and looking right into the camera. She wears pearl jewellery and a tweed blazer.
In 2020, @CKadoch of @kadochlab received an email from a gynecologic oncologist with a research idea. That idea, proposed by @Jstlaurent_MD of @stlaurentlab, has led to findings that support clinical testing of a completely new way to treat endometrial cancer, the fourth most common cancer in women. Hear them tell the story in this inaugural podcast episode of Unraveled Presents: Conversations about Cancer. ➡️ bit.ly/4zOhTXG
As I recall my colleague Ronny Drapkin telling me years ago, most ovarian cancers don't start in the ovary—they start in the fallopian tube, a finding that came out of NCI-funded research. That shift has rewired how we think about prevention. Learn more. go.nih.gov/M3zXBZz
Today, NSF released 12 new notices of funding opportunity providing over $1.5 billion for foundational research across the sciences and engineering. brnw.ch/21x4ZF2
It was a pleasure to write a commentary with @md_napolitano on a recent paper showing how germline BRCA2 mutations can predispose #BreastCancer toward RB1 loss and CDK4/6i resistance—while preserving PARPi sensitivity. Can we anticipate/intercept resistance before it emerges?
Shaping CDK4/6 Inhibitor Resistance: BRCA2 Germline Alterations Bias toward RB1 Inactivation—this In the Spotlight commentary by Fabiana Napolitano and Ariella B. Hanker highlights a recent Nature article from Anton Safonov and colleagues. doi.org/10.1158/0008-5472.CA…@md_napolitano
"Diversity is really important in science. First of all, I think that if you want to have the best scientific outcomes, you need a lot of different brains working on it." – Chemistry laureate Jennifer Doudna on diversity in science.
Read the interview: bit.ly/2M82Chu
ALT Jennifer Doudna, wearing a red jacket, stands with crossed arms smiling next to a window. A model of a CRISPR-Cas9 molecule is on the window sill.
🔬 Now Accepting Letters of Intent: The A2C Grant
Tina's Wish is launching a new grant to move ovarian cancer diagnostic biomarkers into clinical trials. $1M over 2 years + expert advisory resources.
LOI Deadline: Sept 9, 2026 tinaswish.org/acceleration-t…
Scientific impact is hard to measure, but it's key to funding the best science. How can we better predict and reward impactful research? Send your input through our Request for Information on Measuring and Rewarding Scientific Impact by August 19. go.nih.gov/sKK2wOx#RFI
Rebecca Skloot told the story of Henrietta Lacks and how her cells were taken without her permission in a bestselling book, The Immortal Life of Henrietta Lacks. Reading it left Alison George with an uneasy feeling - so she spoke to Lacks's family newscientist.com/article/258…
Parents want accountability after a cutting-edge gene-editing trial in China went disastrously wrong, according to an exclusive investigation from Science and @RetractionWatch.
Learn more: scim.ag/4bfgoao@NewsfromScience
To stay ahead of cancer, we need to understand how tumor cells adapt. This @theNCI study reveals how environmental stress can drive heritable changes in gene expression, offering new insights into one of cancer’s greatest challenges: drug resistance. go.nih.gov/iie4xBv
ALT This diagram shows how environmental stressors like antifungal drugs or high temperatures can trigger a molecular chain reaction inside fission yeast cells, which share many of the same pathways as human cells.\n\nExternal signals funnel through two internal communication networks into a molecular dimmer switch called the heterochromatin heritability regulatory hub, or HRH. When stress turns the dimmer up, the HRH can drive the assembly of tightly packed DNA regions called heterochromatin, locking certain genes off. Those silencing patterns can then be passed on to daughter cells when the cell divides \u2014 no changes to the underlying DNA sequence required. Image Credit: Shiv Grewal
Researchers develop branching lung #organoids that recapitulate lung morphogenesis and epithelial lineage specification, providing a platform to study development, regeneration, and fibrosis repair.
Learn more via @Dev_Cell:
🔖 bit.ly/4xNTSz2