Antibody effector functions and cancer immunotherapy @ Weizmann Institute of Science
Israel
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1/ Why have anti-GITR agonists, despite strong preclinical activity, shown limited clinical success?
Our new study in @NatureCancer points to Fc receptor pathways as a key missing piece.
Led by the amazing @AvYahel, Natasha Barth
nature.com/articles/s43018-0…
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Great conversations, great people, and lots of fun at our Sea of Galilee lab retreat! ☀️🌊
So happy to have @LabTaia and @AmirHorowitz join us!
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Rony Dahan retweeted
Dr. Yahel Avraham, Natasha Barth, and @WeizmannScience colleagues evaluate the in vivo outcomes of distinct human FcγR pathways of anti-glucocorticoid-induced TNFR-related protein (GITR) monoclonal antibodies. 🔗 go.nature.com/4wOzIEj
🔎 They explore the hierarchy of mechanisms underlying their antitumor activity.
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1/ Why have anti-GITR agonists, despite strong preclinical activity, shown limited clinical success?
Our new study in @NatureCancer points to Fc receptor pathways as a key missing piece.
Led by the amazing @AvYahel, Natasha Barth
nature.com/articles/s43018-0…
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6/ Take-home: GITR agonistic mAbs should be viewed not only as receptor activators, but as tool to rewire immune circuits. Proper Fc design can shape the anti-tumor response, promote Treg elimination, and unlock immune cell crosstalk- a framework for next-generation immunotherapy
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7/ Huge credit again to our first authors Yahel & Natasha, and to all members of the Dahan Lab. Grateful to Teva Pharmaceuticals @TevaUSA, @MelanomaReAlli, and @ERC_Research for the support. Proud to do this work at @WeizmannScience.
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Stem cells rock 🤘
Excited to share our new paper in Nature Immunology! 🦠🔬
nature.com/articles/s41590-0…
We uncover a central role for intestinal stem cells in defending the tissue against Salmonella infection.
A huge thanks to all collaborators and team members who made this work possible!
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Rony Dahan retweeted
Excited to share our new @biorxivpreprint from the lab!
We show that intestinal Lgr5⁺ stem cells are active luminal sensors that use apical TLR2 signaling to detect microbiota-derived cues and regulate epithelial differentiation and antimicrobial defense.
biorxiv.org/content/10.64898…
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Beautiful work demonstrating that intestinal epithelial MHC II presentation encodes tissue state to balance tolerance and inflammation. Congrats Moshe and all authors!
Check out our latest pre-print on @biorxivpreprint ! We show that the intestinal MHC II self-ligandome is spatially compartmentalized across villus, crypt, and immune niches, and is dramatically rewired during injury toward damage-associated self-antigens.
doi.org/10.64898/2026.03.18.…
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Rony Dahan retweeted
What if we could turn the tumor’s deadliest tricks against it?
New @Cancer_Cell: Tumor-antigen-independent targeting of solid tumors by armored macrophage-directed anti-TREM2 CAR T cells. Led by @GalYagel, @D_Rimini & @MVLocquenghien (1/15)
cell.com/cancer-cell/abstrac…
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Looking forward to this great meeting
The SMR 2025 Annual Congress (Amsterdam Oct 25-28) covers basic, preclinical & translational melanoma research. It is a very enjoyable conference with top faculty and now improved with ample opportunity for young investigators to learn & network. Join us! smrcongress.org
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Exciting new paper from @IdoAmitLab lab! 🧬🔬
A deep dive into psoriatic arthritis reveals new clues and a promising path for therapy. Cutting-edge science with real translation potential!👇congrats guys!
Excited to share our study in @SciImmunology dissecting the immune landscape of psoriatic arthritis (PsA)—with a new finding: immunoproteasome overactivity drives treatment resistance🧵
Led by Reut Tzemach,Chamutal Gur,@TgSanPhan,Eyal David & team. (1/11)
science.org/doi/10.1126/scii…
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Reprogramming macrophages remains one of the outstanding unsolved challenges in cancer immunotherapy. Huge congratulations to @IdoAmitLab @FadiSheban and the team for tackling this complex task and publishing this impactful study.
We are excited to share our new study @Cancer_Cell identifying Zeb2 as a master genetic switch controlling the tumor-associated macrophage (TAM) program. Led by @FadiSheban, @TgSanPhan, @CuriousKX & @FlorianIngelfi1. (1/20)
cell.com/cancer-cell/fulltex…
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Looking forward for this one! Thanks Natalie and Pierre for organizing this great meeting
✨It’s going to be a fantastic meeting, there are still some spots left. Sign in by the end of the month for earlybird rates #antibodies #complement #scientificconference #therapeuticantibodies @roumenina @ZivShulman @DahanLab @carovinuesa @MOUQUETHugo1 @javid_lab @NussenzweigL
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Just published📢 Our new forum article on Fc-optimized checkpoint antibodies for cancer therapy. New to immunotherapy and antibody engineering? This one’s for you! Co-authored with Alan Korman. @TrendsMolecMed #CancerImmunotherapy #FcEngineering
sciencedirect.com/science/ar…
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