A clinician scientist at LTRI @sinaihealth studying GLP-1, diabetes, obesity and the gut endocrine system Proud 🇨🇦Not going anywhere Am 🇮🇱Chai
Toronto
- Tweets 33,131
- Following 1,422
- Followers 36,896
- Likes 8,748
Pinned Tweet
How do GLP-1 meds improve liver health through #weightloss independent mechanisms? Here @ChusaGzlzRellan & colleagues identify Liver Sinusoidal Endothelial Cells as direct targets of semaglutide, linking LSECs to reduction of #inflammation #Fibrosis #MASH cell.com/cell-metabolism/abs…
6
48
153
16,155
Daniel J Drucker retweeted
SCOOP: Top researchers at Columbia, Stanford, and others thought they were elected to elite scientific societies alongside Nobel laureates. The catch? The organizations are a sham.
I spent the last month investigating a massive academic scam, for @Nature
nature.com/articles/d41586-0…
6
74
193
36,346
A childhood window into genetic variation linked to childhood adiposity @NatureGenet nature.com/articles/s41588-0…
8
26
3,772
Cohort studies across the lifespan for type 2 #diabetes Progress, clinical implementation and future directions @DiabetologiaJnl link.springer.com/article/10…
1
14
42
3,930
Here the authors identify the glucagon-PKA-PDE2A-NCLX signaling axis as a key metabolic rheostat integrating mitochondrial calcium dynamics with lipid homeostasis, providing a promising therapeutic target for MASLD @MolMetab sciencedirect.com/science/ar…
2
9
51
4,003
The weight loss proteome in mice nature.com/articles/s42255-0… @NatMetabolism
15
62
6,760
In an open label study for up to 26 weeks, dulaglutide was associated with greater improvements in glycaemic control and variability compared with insulin among adolescents with transfusion-dependent β-thalassaemia (TDT)-induced diabetes @DiabetologiaJnl link.springer.com/article/10…
3
14
1,759
From TMAO to DNICs the expanding concepts linking microbiota metabolism to cardiovascular and metabolic pathways. Modulating DNIC formation by the gut microbiota could be a strategy to support cardiometabolic health @CellCellPress cell.com/cell/fulltext/S0092…
2
3
15
1,963
New studies in Drosophila and mice redefine the intestinal muscle as a responder to specific signals that adjust adult organ (intestine) features and sustain reproductive demands.
cell.com/cell/fulltext/S0092…
1
4
12
2,167
A framework identifying ten priorities in #T2D prevention, toward context-specific, actionable interventions capable of altering the natural history of disease early in the life course and restoring metabolic health. nature.com/articles/s41591-0…
2
15
44
4,705
The decades long quest for reprogramming islet cell phenotypes #diabetes continues here using a metabolic pathway approach nature.com/articles/s41589-0…
6
21
2,752
Daniel J Drucker retweeted
The GLP-1 drugs have evidence for beneficial impact— heart, kidney, liver, joints, immune system, and brain—that are independent of weight loss
@Cell_Metabolism @DanielJDrucker
cell.com/cell-metabolism/abs…
40
273
1,143
149,064
How does GLP-1 work? Gustav Hållén the producer of Zero Order has figured it out. Have a listen
piped.video/watch?v=VCIWc2TX…
2
4
23
4,530
The scientific journey enabling the development of #microbiome -targeted therapies for #obesity prevention and treatment. An update @cellhostmicrobe cell.com/cell-host-microbe/f…
3
15
2,301
A physiological homeostatic circuit through which obesity causes type 2 diabetes and #insulin resistance @Cell_Metabolism cell.com/cell-metabolism/abs…
6
20
4,554
P2 data over 16 weeks reveal an investigational small molecule GLP-1R agonist HRS-7535 dose-dependently reduced albuminuria, HbA1c and body weight in patients with diabetic kidney disease receiving intensive contemporary therapy thelancet.com/journals/eclin…
1
7
2,258
Automated CT-derived Perivascular Adipose Tissue biomarkers are associated with existing and future #T2D and may enable identification of undiagnosed or high-risk individuals undergoing routine abdominal CT diabetesjournals.org/diabete…
1
7
2,459
Rates of anxiety and depression in real world data from Shanghai in people with #T2D using GLP-1 medicines are low but increase slightly after discontinuation of the medicines @NatMetabolism nature.com/articles/s42255-0…
4
34
3,589
Evaluating the progress in biological clocks #Aging @EricTopol @NatureMedicine nature.com/articles/s41591-0…
1
7
29
3,733
P3 data assessing the efficacy and safety of setmelanotide once daily in acquired hypothalamic obesity over 52 weeks nejm.org/doi/full/10.1056/NE…
3
15
13,873
More evidence from studies of mice deficient in α cells that α cells are required for nutrient homeostasis by regulating the dynamics of β cell networks, notably under conditions of amino acid exposure science.org/doi/10.1126/scia…
15
57
6,304