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Major work out in @NaturePhysics!
Led by @NicaGutu & Malthe Nordentoft — a multi-lab collaboration.
We show that the degree of circadian coherence between cells tunes proliferation rate 📈.
Disrupting coupling breaks clock–cell cycle coordination.
👉rdcu.be/efNaY
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Granada Lab retweeted
It’s a wrap! My final PhD paper in the @Granada_Lab just came out in @CellReports🥳 We identified circadian rhythm heterogeneity and distinct time-of-day drug sensitivity dynamics across neuroblastoma cell models⏰ Thanks to everyone who shaped this work! rb.gy/j7z0sj
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Granada Lab retweeted
Stay up to date with the latest research from e:Med by e:Medium Flash, March edition sys-med.de/en/current/emediu…
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Major work out in @NaturePhysics!
Led by @NicaGutu & Malthe Nordentoft — a multi-lab collaboration.
We show that the degree of circadian coherence between cells tunes proliferation rate 📈.
Disrupting coupling breaks clock–cell cycle coordination.
👉rdcu.be/efNaY
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Huge team effort including @AnnaMarieFinge1, @CarolinEctor & many others — grateful for such a collaborative group. Very thoughtful reviewers’ feedback helped strengthen the work.
Thanks to @medicine_e, @BMBF_Bund & @ChariteBerlin for supporting this project!
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Our latest work is out in @CommsBio. Led by @NicaGutu & Hitoshi Ishikuma, we study how circadian rhythms shape time-of-day drug sensitivity in human cells 🕒💊. Toward time-based cancer therapy.
Supported by @medicine_e, @BMBF_Bund @ChariteBerlin
👉 rdcu.be/ee3FQ
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Happy to share a new very exciting work from my lab! Congrats to @CarolinEctor and the team on their study of circadian clock dynamics in breast cancer cells, now published in @MolSystBiol. @medicine_e @ChariteBerlin funded by @BMBF_Bund
Excited to announce that my second study with the @Granada_Lab, where we elucidated diverse circadian clock dynamics across breast cancer cells and their effect on drug sensitivity, has been published in @MolSystBiol. Thank you to the entire team! embopress.org/doi/full/10.10…
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🚀 Together with @CarolinEctor, we recently published a review in Deutsches Ärzteblatt on Chronobiology in Oncology. Timing therapies for optimal effectiveness! ⏰💊
📌 Currently only in German.
🔗 aerzteblatt.de/archiv/chrono…
#Oncology #Chronobiology #MedicalResearch #CancerTreatment
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Exciting to see this out! Congrats to @Anton36193637 and @shaon_chak ! — fantastic work all around!
Big shoutout to @Anton36193637, who drove this project over the last 4 years, working hard to make sense of all the noisy datasets using carefully designed models and statistical inference techniques. Thanks also to @Granada_Lab for the discussions and collaboration! (6/6)
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New Preprint from our lab, led by @CarolinEctor! We performed deep circadian phenotyping in breast cancer cell lines, uncovering circadian-based subtypes and showing the clock’s role in drug response, predicting drug sensitivity. #circadianbiology #breastcancer @BMBF_Bund
Circadian clock features define novel breast cancer subtypes and shape drug sensitivity biorxiv.org/cgi/content/shor… #biorxiv_cancer
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Thanks to @medicine_e, @BMBF_Bund, @ChariteBerlin
& @DKTK_ for the support! #CancerResearch #Chronotherapy
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Grateful for the excitement around our work on the best time-of-day for drug treatments! Thanks to everyone highlighting the emerging science of chronotherapy—a field built on the pioneering work of many we admire.
News summary in 7 languages: nature.altmetric.com/details….
@SRBRHQ
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Granada Lab retweeted
Very nice article from @Inside_PM, highlighting our recent work published in @NatureComms: insideprecisionmedicine.com/…
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Granada Lab retweeted
Chemotherapie morgens, mittags oder besser abends? Forschende der #CharitéBerlin haben eine Methode entwickelt, mit der der optimale Zeitpunkt für eine Krebsbehandlung bestimmt werden kann. Ihren Ansatz beschreiben sie im Fachmagazin @NatureComms. charite.de/service/pressemit…
ALT Mikroskop-Bild einer triple-negativen Brustkrebszelllinie. Die Zelllinie exprimiert einen Marker für den Zellkern, der für die Echtzeit-Quantifizierung von Zellen genutzt wurde, um die Empfindlichkeit der Zellen zu verschiedenen Tageszeiten zu bestimmen. © Charité | Granada Lab
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Granada Lab retweeted
Chemotherapy in the morning, at midday, or evening? Researchers at #CharitéBerlin have developed a method to determine the optimum time of cancer treatment. They describe their approach in the journal @NatureComms. charite.de/en/service/press_…
ALT Image of a triple-negative breast cancer cell line (MDAMB468), taken with a widefield microscope. The breast cancer cell line expresses a marker for the nucleus, which was used for real-time quantification of cells to determine the sensitivity of the cells at different times of the day © Charité | Granada Lab
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New publication from our group! 🎉 Congrats to all authors, led by @CarolinEctor . We developed a method to use tumor cells' internal clocks to optimize cancer therapy. Thanks to @medicine_e , @BMBF_Bund , @ChariteBerlin & @DKTK_ for the support! #CancerResearch #Chronotherapy
Excited to share the publication of my first paper in
@NatureComms, introducing a comprehensive approach to study time-of-day effects of anti-#cancer drugs ⏰
Many thanks to the whole team, especially Adrián @Granada_Lab! Check out our work here: nature.com/articles/s41467-0…
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Granada Lab retweeted
News from the e:Med Research Community - e:Medium Newsletter Volume 7 is available here: sys-med.de/en/current/emediu… #systemsmedicine #newsletter @KonradAden @Granada_Lab
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Granada Lab retweeted
THANK YOU!!!! to the AMAZING cell signaling community for a fantastic inaugural Dynamics and Encoding in Cell Signaling FASEB meeting. We look forward to getting together in 2026!
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Finally out! "Circadian Coupling Orchestrates Cell Growth"! Our study shows how circadian synchronization impacts the coordination of cellular division, shaping collective growth dynamics. Kudos to @NicaGutu! biorxiv.org/cgi/content/shor…
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Excited to present at #SRBR2024 @SRBR_Outreach! Join us Wednesday morning for Symposium 17 on Circadian Medicine. Grateful for the support from @medicine_e, @BMBF_Bund, and @ChariteBerlin. #CharitéBerlin
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Check out our latest pre-print! Kudos to Carolin Ector and a stellar team of collaborators for their immense effort. We've pioneered a novel high-throughput method to assess how circadian rhythms influence cellular response to drug perturbation. biorxiv.org/content/10.1101/…
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