Today in @NatRevDrugDisc (#NRDD), we proudly present a timely Perspective on the overall druggable landscape of RNA-binding proteins (RBPs), with a strong emphasis on the recent and exciting scientific advances around cell surface RBPs (csRBPs) in disease. Many congratulations and a big thank you to my absolutely amazing colleague @GaiaTimote98110 for putting this inspiring piece together, as well as to my fantastic collaborators and key experts in the field, @AbdelWahablab, Ryan Flynn, and Benson George for their very important contributions! We hope that our Perspective will benefit the wider scientific community by providing a clearer understanding of the therapeutic potential of targeting RBPs and csRBPs. nature.com/articles/s41573-0…

Excited to share our new preprint! 🎉 Using base-editor screens, we reveal how individual residues within the intrinsically disordered region of YTHDF2 control protein interactions, condensate recruitment, and m⁶A-dependent mRNA decay. biorxiv.org/content/10.64898… 🧵👇

Why is glutathione, rather than cysteine, the major cellular thiol? Our new work by @ToshiNakamura51 suggests unlike other amino acids, excess cysteine is intrinsically toxic to mammalian cells via mitochondrial iron accumulation. @RockefellerUniv nature.com/articles/s42255-0…

We used single-cell multiomics to trace the MDS-to-AML trajectory upon #HMA treatment and uncovered how #DNA #methylation clones evolve along the way. Featured in @LeukemiaJnl ! #SingleCellGenomics #AML #MDS #CancerBiology nature.com/articles/s41375-0…

Read our latest: Recurrent non-canonical proteoforms in acute myeloid leukemia identified by integrative proteogenomics biorxiv.org/content/10.64898…

I am thrilled to share that I've received a NHLBI K08 Career Development Award — "The Role of Zbtb1 in Normal and Clonal Hematopoiesis." As an immigrant physician-scientist, this was once a pipe dream — the kind of career that felt like it belonged to someone else's story. None of this would have been possible without the people who shaped this path. My mentors, @KharasLab and @DrMvandenBrink. My advisory committee — @AbdelWahablab, Ivan Maillard, Christina Leslie, @RichardKoche, @KivancBirsoy, and @RossLevineLab. @cedunbar80, @dstarczynowski, and @SteidlUli, for their unwavering guidance and support over the years. And above all, to my family, who has stood beside me through every step. I'm excited for this next chapter and look forward to building an independent research program. To anyone who feels like they don't belong in this room yet: keep going !

Congrats to Briana for defending her PhD, so many amazing directions all coming together! Especially being able to bridge @KeshariLab and @KharasLab. We are looking forward to the things you do next.

Thrilled to deliver tomorrow seminar at the Memorial Sloan Kettering Cancer Center @MSKCancerCenter in #NYC invited by @KharasLab . If you are in the Big Apple, come listen how #epigenetics shapes #cancer

Congratulations to Emerging Leader Award winner @TuomasTammela for being named a 2026 Stephenson Global Scholar!

Thrilled to share our latest work is out today in @Nature ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer. nature.com/articles/s41586-0…

What a wonderful week! Sharing our @LeukemiaJnl single-cell DNA methylation #epigenetics tracing of clonal evolution from #MDS to #AML upon therapy with hypomethylating agents #HMA. Grateful for the help of @landau_lab @WeillCornell nature.com/articles/s41375-0…

Excited to announce a new paper out today in @CD_AACR on clinical mechanisms of resistance to BTK degraders. Led by @QuinlanSievers & our ongoing collaboration with @MCThompsonMD, @Nurix_Tx, & @TaylorJ_MD (U. Miami): aacrjournals.org/cancerdisco…

🚨 Excited to share a new paper in Cell! Human genetics led us to HOTSCRAMBL, a HOXA-locus lncRNA that regulates 🩸#stemcell self-renewal and HOXA9 splicing, with implications for AML. Amazing work by @lvchosen1 with @silvirouskin, @Armstrong_dfci, and many more! cell.com/cell/fulltext/S0092…

Excited to announce a new paper out now in @CD_AACR on a unique CAR T cell platform that eliminates AML and B-ALL without harming vital endogenous immune cells or other normal human tissues: pubmed.ncbi.nlm.nih.gov/4205…

Eli Lilly continued its recent buying spree, agreeing to pay up to $2.3 billion for Ajax Therapeutics in a deal that bolsters the drugmaker’s blood-cancer portfolio. on.wsj.com/4vSypnF

On the cover of this month's issue of Nature Nanotechnology! Our nanosensor + AI-based liquid biopsy (blood test) for brain tumors that also enables the discovery of new biomarkers. nature.com/articles/s41565-0…

Hello everyone! We're participating in @Cycle4Survival to raise money for rare cancer research at @MSKCancerCenter, and your support would mean so much to us. Make a 100% tax-deductible donation using the link. Thank you! secure2.convio.net/mskcc/sit…

Researchers @MSKCancerCenter @WeillCornell Discover PGBD5 Guides Normal Brain Development in Addition to Causing Cancers mskcc.org/news/researchers-d…

Researchers identify PGBD5, a transposase-derived gene, as an essential regulator of normal brain development in mice and humans. Learn more in this week’s issue of Science Advances: scim.ag/4pGsjT8

People with TP53 mutations have blood stem cell clones (CHIP) which promote chronic inflammation, aging, and risk of blood cancers. This can be blocked by multiple means (as shown below) to potentially prevent cancer, but CHIP is not assayed in the clinic. jci.org/articles/view/184285 @jclinicalinvest