Rouge Professional | BioE PhD Candidate @WormBuilder @KAUST_News | ChemE @UCBerkeley | Clown | Tweets on #SynBio #GlowWorms #GeneEditing #Failing
Synthetic Genome Biology Lab
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We did a thing! Super proud to be part of this group.
Very proud of the students and postdocs in my lab behind our new paper. We describe a set of rules to optimize germline expression and reagents to improve gene editing efficiency in C. elegans. nature.com/articles/s41467-0…
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Want to make a worm glow? Come say hi! I may or may not have candy (poster no. 57) #cshlCRISPR23 @CSHL
Excited that a talented Ph.D. student Mohammed Aljohani @MDJEditing from my lab is presenting his work on a genome-wide C. elegans CRISPR library for DNA and RNP-based CRISPR editing for the first time today at the CSHL CRISPR meeting.
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Mohammed D. Al Johani retweeted
Modular safe-harbor Transgene Insertion (MosTI) for targeted single-copy and extrachromosomal array integration in C. elegans. biorxiv.org/cgi/content/shor… #bioRxiv
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Mohammed D. Al Johani retweeted
Happy to see our paper on piRNA-mediated silencing and transgenerational inheritance in C.elegans in print.
Thanks to Sam Gu @ Rutgers for a great collaboration! nature.com/articles/s41592-0…
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Mohammed D. Al Johani retweeted
1/5 Our paper is out as a bioRxiv preprint. @sonia_elmouridi and @FaisalMAlkhaldi Like MosSCI, just better. Targeted single-copy and array integration synthesizing new and gradual improvements from the past 15 years across many labs. biorxiv.org/content/early/20…
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Mohammed D. Al Johani retweeted
I made an opto cell line and it's the coolest thing ever!
I feel like a wizard pointing at cells and making them contract 🧙♂️.
Here is local RhoA activation by recruitment of LARG.
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Mohammed D. Al Johani retweeted
That dorky sense of accomplishment when you finally find a restriction site for genotyping a knock-in that encodes a flexible linker dipeptide that does not introduce phosphorylatable amino acids. SfoI! In frame, encodes a gly-ala. AND cuts in Phusion HF buffer.
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Mohammed D. Al Johani retweeted
Looking for a better negative selection marker for C. elegans transgenesis than peel-1? My postdoc and Master's student developed a simple histamine-based system that works like a charm. pubmed.ncbi.nlm.nih.gov/3343…
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Mohammed D. Al Johani retweeted
Are genomes of identical twins really identical? "Our results indicate that allocations of cells during development shapes genomic differences between monozygotic twins." rdcu.be/cddS6 @NatureGenet
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Mohammed D. Al Johani retweeted
I had to “sink or swim” in my undergrad lab, and because I swam, I assumed it was a good system. After having supportive mentors, I realize I could have learned so much more with proper guidance. Don’t let people sink just because it’s the way it was for you! #AcademicChatter
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Mohammed D. Al Johani retweeted
Our review (@timlu & Zhong lab) on designing living materials using synthetic biology is out! We covered recent advances & prospects and summarized #synbio tools for programming smart living materials with various functionalities.
rdcu.be/ccNg0
nature.com/articles/s41578-0…
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Mohammed D. Al Johani retweeted
1/n Rounding out the best of 2020 for our lab, newly published “Engineering Cell Fate: Applying synthetic biology to cellular reprogramming.” We review cellular reprogramming+#synbio Vision brought to life in vivid color by @nbwang22 and @beitz_adam
sciencedirect.com/science/ar…
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Mohammed D. Al Johani retweeted
Introducing IN SITU GENOME SEQUENCING, a new technology to resolve DNA sequence🧬 and structure🔬
A team effort with @Andrew_C_Payne, @PaulReginato, @eboyden3, @JD_Buenrostro, and Fei Chen
science.sciencemag.org/conte…
This is how it works: (1/8)
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Mohammed D. Al Johani retweeted
is my code fast? no. but is it well documented? no. but does it work? also no.
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Mohammed D. Al Johani retweeted
40 million years ago, ticks stole a gene from bacteria. Today, they use the enzyme that gene makes to fight off bacteria on our skin.
sciencenews.org/article/how-…
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