ALT DecodeME: The Results announcement post. The graphic has a blue background with a DNA helix. In the centre of the graphic it says ‘We have released our initial DNA results! We have discovered that your genes contribute to your chances of developing ME/CFS.’ At the bottom left of the graphic is an image of a research paper.

ALT Commentary Nov 1, 2024 https://doi.org/10.32388/NXCXM1 The Concept of ME/CFS Jonathan Edwards1 Highly-cited researcher Declarations University College London, University of London, United Kingdom Abstract The concept of ME/CFS (notionally standing for myalgic encephalomyelitis/chronic fatigue syndrome) has evolved over the last twenty years. This review compares it with the historical terms chronic fatigue syndrome, myalgic encephalomyelitis, and also post-viral fatigue syndrome, arguing that ME/CFS is better suited to both clinical and research needs, focusing on a symptom-based syndrome characterized by post-exertional malaise, orthostatic intolerance, and an unpredictable, fluctuating time course, rather than specific physiological markers. The need to dissociate the clinical concept from speculative theories of aetiology is emphasised. The breakdown in effective care, especially for severe cases, is highlighted and suggestions made for re-instituting a physician-led service that m

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