Translational research lab at @PennCVI @PennMedicine studying heart failure
Philadelphia, PA
- Tweets 85
- Following 187
- Followers 227
- Likes 121
Pinned Tweet
Welcome to the Margulies Lab twitter! We’re excited to be here and share all things heart related 🫀
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Grateful to have worked with such a dedicated team in the @AranyLab and @MarguliesLab to bring this discovery to fruition. And thanks @SarnoffCardio for all your support!
We've not understood why SGLT2 drugs (like empagliflozin, Jardiance) have marked protective heart benefit.
Today @ScienceMagazine a mechanism unraveled for improving cardiac metabolism and fuel efficiency
science.org/doi/10.1126/scie…
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#MechanicalStress to #MetabolicDysfunction & #Contractile impairment with #Cytoskeletal #Remodeling & #AMPK #Signaling as potential #TherapeuticTargets in #HeartFailure doi.org/10.1016/j.celrep.202… @MarguliesLab #TranslationalScience
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In KETO-HFpEF, we integrated CPET, echo, lung US, tonometry, metabolites, isotope tracer, & leg MRI. Ketone ester didn't ⬆️ exercise, despite ⬇️filling pressure & glucose use at rest/exercise
Simpub #ACC25 #JACCHF
🙏 #PZamani @MarguliesLab &team
@PennCardiology @DukeHeartCenter
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From monocytes pulling matrix by @KoladeAdebowal1 to cardiac in vitro models by Benjamin Lee from @MarguliesLab we continue the mechanobiofun at #cmbes2025 @ucsdbe @PennMedicine @PennCVI @UCSDJacobs
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Our phase I study of 2 doses of exogenous ketones detailing PK and metabolic profiling in HFrEF by background SGLT2i
Simpub #AHA24 & @JACCJournals #JACCBTS
jacc.org/doi/10.1016/j.jacbt…
🙏 @SvatiShah @MarguliesLab @robmentz @FudimMarat and outstanding team
@DukeHeartCenter @DukeMPI
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Congratulations @mikeibrahimmd !!
The @STS_CTsurgery has awarded @mikeibrahimmd 🩺 funding to research t-tubule remodeling in the cardiac muscle cells of people w/ #heartfailure.
This is the 1st time the award 🏆 has been granted to a cardiothoracic surgeon.
Learn more ⬇️ spr.ly/6010Wuwe2
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Congratulations to @AlexiaVite93 on placing in the Lightening Talk competition at @ISHR_NAS meeting in Long Beach, CA
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We think this one is groundbreaking: Do you wonder how #SGLT2 inhibitors protect from heart failure? We show that #empagliflozen directly activates PANK1, rate-limiting for CoA synthesis, in human hearts. You read it here first! biorxiv.org/content/10.1101/…
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Small molecules that inhibit vasohibins and alpha-tubulin #detyrosination can promote myocardial relaxation and counteract heart muscle cell stiffness in a rat model of #HeartFailure with preserved ejection fraction. @MarguliesLab @Prosser scim.ag/7Nf
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Can we "drug" microtubule modifications to lower cardiac stiffness and improve function in #HFpEF? Out now in @ScienceTM , w/ long time collabs in @MarguliesLab
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tinyurl.com/ynn6r2mz
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A new study by @Prosser_Lab and @MarguliesLab found that inhibiting vasohibin reduced heart muscle stiffness. This could lead to new treatments for heart failure with preserved ejection fraction (HFpEF) spr.ly/6013i9WMc
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Congratulations Alexia Vite! Awarded the American Heart Association’s Career Development Award and the Second Century Early Faculty Independence Award
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Congratulations to lab member/Research Assistant Professor @AlexiaVite93 on being awarded both (!!) the AHA CDA and Second Century Early Faculty Independence Award!
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Excited about our latest work in @JMCCPlus showing colchicine improves diastolic performance in myocardial slices. Congrats @EmmaleighHancoc and thanks to Brad Palmer, @IonOptix , @UVMLarnerMed , and @uvmcvri for making this possible!
sciencedirect.com/science/ar…
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New research examines the functional impact of alternative metabolic substrates in failing human cardiomyocytes ft. @AlexiaVite93, Timothy Matsuura, @kbedi88, Emily Flam, @AranyLab, @DanKellyPennCVI & @MarguliesLab (@PennCVI/ @PennCardiology) tinyurl.com/msp5hsma
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Mechanical memory of human iPS-derived fibroblasts and cardiomyocytes.
link.springer.com/article/10…
ALT Induction of mechanical memory in iPSC-CMs. Schematic of the MRE model with the reversible stiffening and softening capabilities showing the stiff priming and softening phases as well as the soft and stiff controls. Temporal dynamics of iPSC-CMs surface area remodeling following culture on stiff, soft-to-stiff, and soft conditions. Significance of difference between stiff and soft: *p < 0.05. Significance of difference between stiff-to-soft and stiff: + p < 0.05.
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In our new study led by @NesrineBouhrira , we explore how rapid induction of stiffness-induced mechanical memory in cardiomyocytes suggests potential interventions for maladaptive myocardial stiffening @BasicResCardiol @AlexiaVite93 link.springer.com/article/10…
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