Associate Professor @MITBiology. Interested in how cells generate force and how they work together to sculpt tissues.
Cambridge, MA
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Join us at the 2025 Cell Contact and Adhesion @GordonConf. Great people and great science!
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Thus, we showed a relay system that doesn’t just result in a wave of the same shape change, but a trigger mechanism for one mode of morphogenetic change jump-starting another.
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These cell adhesion complexes serve as a scaffold to recruit actomyosin through patterned mechanical feedback. Thus, EGFR + mechanical pull recruits actomyosin. Work from @StreichanS demonstrated this patterned feedback and we showed that it is linked to EGFR.
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We identified a mechanism that regulates both Drosophila mesoderm internalization and body axis extension. We showed that EGFR signaling, whose earliest known embryonic role was patterning the central nervous system, establishes a DV pattern of graded levels of cell adhesion.
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Pleased to share the publication of our paper showing the role of EGFR in coordinating morphogenetic movements in Developmental Cell. Congratulations @MITBiology postdoc, @natclarke8 for all your hard work!
Article: pubmed.ncbi.nlm.nih.gov/3946…
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Online now: Postdoc Nat Clarke's @natclarke8 excellent work on a mechanism that coordinates tissue folding and axis extension. Great job and congratulations Nat!
Online now: EGFR-dependent actomyosin patterning coordinates morphogenetic movements between tissues in Drosophila melanogaster dlvr.it/TFkc2d
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Much of science is finding ways to perform mundane tasks in a way that entertains you and serves other purposes as well. It took me ~ 10 miles of walking to flip the entire collection of flies.
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So much successful science involves people behind the scenes making the jobs of faculty, students, and postdocs possible. They don't often get the recognition they deserve, but are truly appreciated by those they support. Great job John Fucillo, you are a pleasure to work with!
Building 68 manager John Fucillo’s leadership, innovation, and laid-back attitude have built a community culture that will never be taken for granted. #staffspotlight biology.mit.edu/staff-spotli…
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Congrats to @natclarke8 and Uzuki Horo for their study being highlighted by @ASCBiology.
FROM MBoC
This study unravels the complex dance of the cytoskeleton during Drosophila gastrulation, revealing how Fog/Cta & T48 pathways uniquely & collectively guide early embryo development.
molbiolcell.org/doi/10.1091/… @mShaneHutson @MIT @MartinLabMIT
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That is a ridiculous pace, especially considering the temperature! Great job! I didn't see you, but I was cheering everyone on.
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