A quick take on the Genmab epcoritamab announcement in 1L DLBCL – are we conquering aggressive lymphomas and improving outcomes for patients? tinyurl.com/395crsfz

A quick take on the Genmab epcoritamab announcement in 1L DLBCL – are we conquering aggressive lymphomas and improving outcomes for patients? tinyurl.com/395crsfz

A design approach for bitopic kinase inhibitors (Open Access) Stevenson, J.W., Lou, K., Reynolds, J.A. et al. A design approach for bitopic kinase inhibitors. Nature(2026). doi.org/10.1038/s41586-026-1… (first bitopic kinase inhibitors to enter clinical trials: RMC-5552)

Ten experiments and the shape of things to come: a look at 10 early stage developments to watch out for at #ESMO26 and what issues you need to pay attention to: tinyurl.com/mtm2xe7f

Noah Sanchez was just three years old when he was diagnosed with a form of brain cancer called medulloblastoma and given a 15 percent chance of survival. Thankfully, Noah is now cancer-free and will celebrate his 26th birthday this month. His advice for others is: “Take time for yourself, but don't try to do it all by yourself. Accept help. Feel the feelings. Stay strong and have faith.” 💛 This #ChildhoodCancerAwarenessMonth, help more kids like Noah by donating to fund pediatric cancer research at StandUpToCancer.org/Pediatri….

Preprint by Bill Sellers @DanaFarber @broadinstitute: Context-specific genetic interaction mapping reveals combinatorial KRAS/FGFR dependence in #PancreaticCancer biorxiv.org/content/10.64898… Digenic CRISPR screens identify attenuating FGFR signaling as most effective pair with KRASi

Our review is online at @Gut_BMJ concurrent with #AACRPan26 Metastatic #PancreaticCancer: from human disease to preclinical modelling gut.bmj.com/content/early/20… Co-authored with @jiminmin_v @PeterYuMD @Perlmutter_CC @nyulangone & colleagues from @CNIOStopCancer

🧬 #ScienceSaturday Could cancer cells accidentally expose themselves to the immune system while trying to spread? A new study in @NatImmunol reveals a surprising link between metastasis and antitumor immunity. 🔬 Researchers found that as cancer cells move through blood vessels, they can release tiny structures called migrasomes. These #migrasomes carry tumor antigens, essentially pieces of information that can help the #immune system recognize cancer. 🛡️ Antigen-presenting cells can pick up these tumor-derived migrasomes and use them to activate CD8+ T cells, helping generate an immune response against metastatic cancer cells. What makes this especially interesting is the paradox: the process of metastasis itself may create an opportunity for the immune system to detect the cancer. In experimental models, reducing migrasome formation led to more metastasis, while restoring tumor-derived migrasomes helped re-establish immune control. 💡 Why does this matter? #Metastasis is one of the biggest challenges in cancer treatment. Understanding how the immune system recognizes cancer cells as they spread could reveal new ways to strengthen antitumor #immunity, and potentially inspire new therapeutic strategies. It’s another example of how closely #cancer and the immune system are intertwined, even during the very process tumors use to spread. @NatureComms @NatureMedicine @Nature @Tsinghua_Uni @ZJU_China @IHuaXi @SCUCN 📄 Read the study: nature.com/articles/s41590-0…

All aboard the #ESMO26 train! Before everyone heads off to Madrid, it's time for our annual Preview series to begin. In the first one we look at the big picture and what trends are emerging this year: tinyurl.com/3brjduue

Excited to share our new piece in Cancer Discovery on targeting RAS for pancreatic cancer interception, written with amazing Hopkins colleagues @Sandra_Misale @NeehaZaidi @alisonpklein @DrLizJaffee : aacrjournals.org/cancerdisco…

A small molecule turns an onco-protein into a polymer and thereby triggers its destruction. This striking route to targeted protein degradation is exemplified by BI-3802. It binds transcription factor B cell lymphoma 6 (BCL6) and induces its reversible assembly into filaments. The resulting supramolecular structure promotes ubiquitination by the SIAH1 E3 ligase and proteasomal degradation of BCL6. Cryo-EM revealed how the drug becomes part of the protein–protein interface that drives polymerization. 1/

Save the date! 🔥 The 2027 FASEB Science Research Conference on Ferroptosis: From Mechanism to Medicine is coming to Denver, July 12–15! We are excited to bring the ferroptosis community together again. Experts and newcomers welcome! Please help spread the word! More info soon!

Three lung cancer phase 3 trials selected for presidential sessions at #ESMO26 ! I have been honoured to chair the metastatic lung track this year w 2 proffered paper & 2 rapid oral sessions & even more phase 3 trial results in EGFR lung cancer, radiation, & IO! #lcsm @myESMO

Thx for the prayers — Turns out cutting out chunks of yer liver is no joke, man. Good news, bad news, and next steps… Good: big liver surgery last week successfully cleared out a bunch o cancer. (Pretty darn great — considering 9 mons ago, when told I had 3-4 months to live, surgery wasn't even an option.) Bad: Tests on the tumors show they were more advanced than we thought — meaning always-mutating tumors have developed some resistance tricks to our former treatment protocol. Bummer but that's life, and was eventually expected. Next: We're gunna change up treatment to carpet-bomb-chemo as much of the rest of the cancer as we can for a bit. Send chemo tips -- do NOT send more Nickelback promotional materials (am painfully aware they’ll be performing at the Hondo Rodeo Fest in Febr). Grateful to God for this extra time — both time w/ fam and time to fight. Can't say enough good things about… - daraxonrasib - ⁠MD Anderson’s incredible team of docs, nurses, techs, & researchers - ⁠my wife: Melissa rocks. She’s laughing-crying-fighting-prayin with me every day. Best human I know. - ⁠Corrie, Alex, and Breck are beyond awesome.

Don't miss the signal! 10 ways in which novel cancer targets could emerge over the next decade: tinyurl.com/2d62xsbt

SURPRISE! Key interferon-stimulated genes (ISGs) can be induced without interferon! Sounds like an oxymoron, but it is true! Read the paper to find out more. Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activation: Cell cell.com/cell/fulltext/S0092…

Yikes this is utterly nuts – and I once complained about paying €15 for sourdough fougasse from a master baker in Norway...