Professor of Molecular Therapeutics and Metabolic Biology at UC Berkeley; Departments of Molecular & Cell Biology and Nutritional Sciences & Toxicology
Berkeley, California. USA.
- Tweets 10,000
- Following 6,373
- Followers 11,138
- Likes 47,750
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1/ Thrilled to share our new paper in @Nature: “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” From our lab together with @apsarruda, led by co–first authors @alymathiowetz and @EmilyMeymand. 🥳
nature.com/articles/s41586-0…
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James Olzmann retweeted
We are excited to announce a new faculty position in AI for Biology at UC Berkeley, jointly between @Berkeley_EECS and @CCBBerkeley.
Please repost & share this opportunity with outstanding early-career researchers in your networks.
Apply by Nov 9, 2026: aprecruit.berkeley.edu/JPF05…
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James Olzmann retweeted
UCSF’s Kevan Shokat, PhD, just won the $1M Stephenson Global Prize for research in pancreatic cancer. He cracked KRAS, a cancer driver long considered “undruggable.” Drugs built on his work now treat lung and pancreatic cancer. ow.ly/xVlw50ZRSXh
ALT Middle-aged man in a blue lab coat smiling while seated in a scientific laboratory setting.
ALT Hand wearing black glove holding five small glass vials with various colored liquids, including pink and orange hues.
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James Olzmann retweeted
Curious how lipid droplets support innate immunity in our cells? Check out our lipidomics by Bosch et al @CellReports! Critical role of LD phospholipids and lipases in supplying defensive w6 arachidonic acid for inflammation and bacterial phagocytosis. cell.com/cell-reports/fullte…
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James Olzmann retweeted
Thrilled to share our new paper in Science!
science.org/doi/10.1126/scie…
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James Olzmann retweeted
🔬Event report🔬
UC Berkeleyからお越しのJames Olzmann先生をお迎えして座談会を行いました🥳
先生のこれまでのキャリアパスについて伺い、新しい分野に挑戦する際のマインドセットなど、多くの学びを得ることができました。
@OlzmannLab Great respect for your journey. Thank you very much!!
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Excited to see this online and to have contributed in a small way! Huge congratulations to @Sulfur_Vladi, Takaaki Akaike & team. Elemental sulfur (S8) accumulates in lipid droplets, & protects against lipid peroxidation and ferroptosis! 🔥
science.org/doi/10.1126/scie…
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James Olzmann retweeted
サバティカルで東北大学に滞在中のJames Olzmann教授@OlzmannLab のセミナーが10月8日に開催されます。興味のある方は是非ご参加ください。#Ferroptosis #lipidbiology #lipiddroplet
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James Olzmann retweeted
#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas
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James Olzmann retweeted
Once again, U.S. News & World Report (@usnews) has named UC Berkeley the #1 public university (tied). Berkeley has topped the rankings for much of the 21st century. 🥇 bit.ly/4xFfAUF
![A multicolored gradient over an image of a clock tower. Text over the image reads "UC Berkeley", "#1 public university", "According to U.S. News & World Report 2027 Best Colleges"]](/pic/orig/media%2FHSy0_fdbgAAO9Vr.jpg)
ALT A multicolored gradient over an image of a clock tower. Text over the image reads "UC Berkeley", "#1 public university", "According to U.S. News & World Report 2027 Best Colleges"]
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Save the date! 🔥 The 2027 FASEB Science Research Conference on Ferroptosis: From Mechanism to Medicine is coming to Denver, July 12–15!
We are excited to bring the ferroptosis community together again. Experts and newcomers welcome!
Please help spread the word! More info soon!
Made with AI
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James Olzmann retweeted
Fantastic visit and seminar by Heather @ChristofkLab to our #MolecularTherapeutics series @berkeleyMCB. Heather’s work is truly unique in connecting fundamental metabolic insights to translation & therapy!
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Two decades after revealing the mechanism of action of auxin, we have now uncovered the molecular mystery of another plant hormone: salicylic acid (SA), the precursor of aspirin that most of us have taken at some point in our lives. We were surprised again rdcu.be/EbdVwEStSHha
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James Olzmann retweeted
Our new paper revealing the link between cholesterol and the clearance and recycling of damaged mitochondria is now published in @NatureComms! Congrats to @YHaoning & Koji @NTUsg who led the study, and thanks to Aik Yong & @Isaspore @NUSMedicine for CLEM! nature.com/articles/s41467-0…
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James Olzmann retweeted
Why is glutathione, rather than cysteine, the major cellular thiol? Our new work by @ToshiNakamura51 suggests unlike other amino acids, excess cysteine is intrinsically toxic to mammalian cells via mitochondrial iron accumulation. @RockefellerUniv
nature.com/articles/s42255-0…
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James Olzmann retweeted
In the latest issue! Metabolite buffering of labile iron governs ferroptosis dlvr.it/TVK0lZ
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Excited to see our Preview led by Amalia Megarioti online in Cell, highlighting new work showing that polyamines act as endogenous buffers of labile iron to suppress ferroptosis. Congrats to Pushkal Sharma, Whitney Henry, Ankur Jain and team!👏
cell.com/cell/fulltext/S0092…
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James Olzmann retweeted
UC BerkeleyのJames Olzmann教授 @OlzmannLab がサバティカルを利用して４ヶ月間 東北大学医学部に滞在されます。
Olzmann教授はフェロトーシスや脂質バイオロジーの専門家で、この滞在を利用して日本国内の研究者とも共同研究やdisucssionをさらに進められる予定です
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James Olzmann retweeted
My group in Discovery Oncology at @genentech uses machine learning to design new ways to target previously "undruggable" cancer-causing proteins.
Go #InTheLab with me to learn more about connecting Oncology and AI--
linkedin.com/posts/genentech…
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James Olzmann retweeted
Excited to share our latest preprint led by Taylor Nuttall, in collaboration with @GileadSciences !
We identify a stereoselective covalent small molecule targeting the “undruggable” ovarian cancer transcription factor PAX8.
KL6-159A covalently engages PAX8 C57, destabilizes PAX8, and suppresses its oncogenic transcriptional program, with FOXM1 emerging as the most strongly suppressed regulatory network.
Another example of how reactive amino acid hotspots can provide unexpected footholds for directly drugging historically intractable transcription factors.
biorxiv.org/content/10.64898…
#Chemoproteomics #ChemicalBiology #DrugDiscovery #PAX8 #OvarianCancer biorxiv.org/content/10.64898…
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