Applications are open for the UC Berkeley MBT Summer 2027 cohort! Join our Oct. 7 info session at 5 PM PT to learn about the program. Register: bit.ly/MBTInfoSessionOct2026 #UCBerkeley #BerkeleyMBT #Biotech

Excited to see this online and to have contributed in a small way! Huge congratulations to @Sulfur_Vladi, Takaaki Akaike & team. Elemental sulfur (S8) accumulates in lipid droplets, & protects against lipid peroxidation and ferroptosis! 🔥 science.org/doi/10.1126/scie…

Exciting research from the lab of MCB's Helen Bateup (@BateupLab)! 🧪@bobthesciguy news.berkeley.edu/2026/09/23…

Congrats to MCB's Fyodor Urnov (@UrnovFyodor) who was honored with the 2026 UC Regents Innovation Gamechanger Award! 👏🎉 mcb.berkeley.edu/news-and-ev…

Researchers at @berkeleyMCB demonstrated that strong and sustained type I IFN responses specifically and cell intrinsically impair responsiveness to #IFNγ to cause susceptibility to #MycobacteriumTuberculosis. 🫁 Learn more: bit.ly/4cNybpV | #OpenAccess

Spotlight: Bartolutti, Brar et al. @berkeleyMCB (hubs.la/Q04y7fcJ0) describe how physiological UPR induction drives #gametogenesis in budding #yeast. David Pincus @UChicago and Vladimir Denic @MCB_Harvard discuss the work: hubs.la/Q04y7f950 #ProteinHomeostasis

Congratulations to MCB's Hernan Garcia (@HernanGGarcia), who has been named a 2026 Schmidt Science Polymath by @schmidtsciences! Garcia joins a cohort of eight scientists pursuing ambitious questions beyond their established areas of research. 👏🧪 schmidtsciences.org/2026-pol…

Exciting research from the labs of MCB’s David Savage (@SavageCatsOnly) and Christina Listgarten, featuring MCB postdoc Maria Lukarska (@MariaLukarska)! 🧬🔬

Congratulations to Gokul Upadhyayula on his promotion to MCB Associate Professor in Residence! 👏 mcb.berkeley.edu/news-and-ev…

Congrats to MCB PhD alum Sophie Dumont @DumontLab on being named a 2026 ASCB Fellow! 👏

QB3-Berkeley faculty affiliate Jennifer Doudna helped pioneer CRISPR, a breakthrough that gave Victoria Gray a new chance at life after 34 years of debilitating sickle cell crises. Read more in Berkeley News: news.berkeley.edu/2026/08/17…

Congrats to the @ASCBiology MBoC 2026 Early Career Award winners! 🧬👏 Their outstanding papers showcase exciting science and important contributions to the field. Drubin Lab: Samantha Smith & Yuichiro Iwamoto and Ünal Lab: Madison Walsh ascb.org/society-news/ascb-m…

Congratulations to Diana Bautista of UC Berkeley, recipient of the 2026 E.E. Just Lecture, recognizing outstanding scientific achievement. ascb.org/society-news/ascb-a…

Today, the UC Berkeley MBT cohort completed its first industry site visit of the year at the Buck Institute for Research on Aging. #UCBerkeley #MBT #Biotech

Excited to share our latest preprint led by Taylor Nuttall, in collaboration with @GileadSciences ! We identify a stereoselective covalent small molecule targeting the “undruggable” ovarian cancer transcription factor PAX8. KL6-159A covalently engages PAX8 C57, destabilizes PAX8, and suppresses its oncogenic transcriptional program, with FOXM1 emerging as the most strongly suppressed regulatory network. Another example of how reactive amino acid hotspots can provide unexpected footholds for directly drugging historically intractable transcription factors. biorxiv.org/content/10.64898… #Chemoproteomics #ChemicalBiology #DrugDiscovery #PAX8 #OvarianCancer biorxiv.org/content/10.64898…

MS2 in zebrafish! Elizabeth Eck, @bmoretti_bio and Brandon Schlomann, in collaboration with @loicaroyer and @OatesLab labs, discovered that smooth protein oscillations in the segmentation clock are the result of discrete transcriptional pulses. doi.org/10.1101/2024.01.03.5…

This week, we wrapped up faculty presentations for MBT students. Thank you to the UC Berkeley faculty who are willing to mentor, or have already mentored, MBT students interested in the academic research track. #UCBerkeley #MBT #Biotechnology #ResearchTraining

Happy to share our new paper on TnpB, now out in @MolecularCell ! 🧬🔓🌱 This work was co-led by @ZehanZhou, Iren Saffarian-Deemyad, @TrevorWeiss480, and me. We wanted to understand why TnpBs, despite being remarkably compact RNA-guided nucleases, often show limited genome-editing activity. Using single-molecule rotor-bead tracking, we found that Ymu1 TnpB unwinds its DNA target step by step, and that reaching and maintaining the fully unwound state is a major bottleneck. 🔬 By stabilizing these unwound states, we engineered a TnpB variant that cleaves DNA faster and improves genome editing in Arabidopsis. ☘️ This project brought together single-molecule biophysics, biochemistry, protein engineering, and plant biology. I’m very grateful to all our co-authors and to everyone in the Jennifer Doudna, Zev Bryant, and Steve Jacobsen labs who made it possible, as well as the broader communities at the Innovative Genomics Institute, @berkeleyMCB , @bioe_stanford , @UCLA , and @hhmi_science. For me, this work is a wonderful example of what interdisciplinary and collaborative science can make possible. 🤝 🌟 Papers 👉 cell.com/molecular-cell/abst… #TnpB #GenomeEditing #CRISPR #ProteinEngineering #Biophysics #Biochemistry #SingleMolecule #CollaborativeScience #Collaboration #PlantBiotechnology #PlantBiology #TeamScience

Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells nature.com/articles/s41587-0…

Bartolutti, Brar et al. @berkeleyMCB show that physiological function for the #UnfoldedProteinResponse differs dramatically from its canonical role in driving a transcriptional program. hubs.la/Q04tJl160 #Development #ProteinHomeostasis #ER_literature #Meiosis